13th World Congress for Laser Dentistry
26-28, April 2012
Barcelona, Spain
Meeting Abstract
Sponsors: World Federation for Laser Dentistry
- Poster 105
TITLE: The effect of low – level laser
irradiation on malignant blood cells: an in vitro study.
AUTHORS: Hosseinkazemi H, Dastanpour S, Bitolahi J,
Saber
K.
Department of Oral Medicine, Tehran University of
Medical Science
SOURCE: Med Oral Patol Oral
Cir Bucal. 2012 May 1;17(Supplement1):S253.
* doi:10.4317/medoral.17643753
http://dx.doi.org/10.4317/medoral.17643753
Abstract
Objective: the aim
of this study was to investigate of different doses (J/cm2) of 810nm
laser irradiation on cell proliferation of acute myelogenous leukemia
cell line (KG-1a), in vitro.
Background: laser
phototherapy is used in the clinical treatment of chemotherapy –
induced mucositis in the patients with
leukemia, despite limited safety information. It has been suggested that laser
light may have biostimulatory effect on
tumor cells. This study contributes to systematically developing guidelines for
the safe use of laser in chemotherapy – induced mucositis.
Methods: Human
acute myelogenous leukemia cell line
(KG-1a) were irradiated with a single, two and three exposures at the energies
of 5, 10, 20 J/cm2. Seven days after cell culture, cell
proliferation was assessed.
Results: Although
certain doses of laser increased KG-1a cell proliferation, multiple exposures
had no effect on dose response relationships.
Conclusion: Before
a definitive conclusion can be made regarding the safety of laser for
chemotherapy – induced mucositis in
leukemic patients, further in vivo research is required.