13th World Congress for Laser Dentistry

26-28, April 2012

Barcelona, Spain

Meeting Abstract

Sponsors: World Federation for Laser Dentistry

- Oral Presentation 98

TITLE: Optical diagnostics and photodynamic therapy for actinic cheilitis.

AUTHORS: Kurachi C, Takahama Jr. A, Fontes KBFC, Barroso DRC, Azevedo RS.

Physics Institute of São Carlos, University of São Paulo and Fluminense Federal University

SOURCE: Med Oral Patol Oral Cir Bucal. 2012 May 1;17(Supplement1):S98.

* doi:10.4317/medoral.17643597

http://dx.doi.org/10.4317/medoral.17643597

Abstract

Actinic cheilitis is an inflammatory condition of the lips caused by an extensive ultraviolet radiation exposure. It is considered a potentially malignant lesion, so its diagnostics and treatment is of great relevance. Gold standard diagnostics is the histopathology after a punch biopsy. The heterogeneity of the lesion makes the biopsy site determination not a simple task. The most used treatment is the topical application of diclofenac gel 3%, twice a day for 6 months. Twenty patients with lower lip actinic cheilities were investigated using fluorescence imaging and spectroscopy, and the diagnostic resolution was compared to histopathology. Ten patients were treated with diclofenac gel 3%, and 10 patients with Me-ALA photodynamic therapy. For the PDT group, a 20% Me-ALA topical cream was placed over the lower lip, and after 3 hours, the area was irradiated with a 630 nm LED-based device at 100 mW/cm² and 40 J/cm². After treatment, the patients were evaluated considering clinical results, optical diagnostics, and histopathology after 30 days. Fluorescence imaging and spectroscopy showed good correlation with the histopathology, demonstrating their potential as auxiliary tools in diagnostics. Photodynamic thera-py showed to be an alternative treatment for actinic cheilities with positive clinical results.