Abdallaoui-Maan
L, Bouziane A. Effects of timing of adjunctive systemic antibiotics on the
clinical outcome of periodontal therapy: A systematic review. J Clin Exp Dent.
2020;12(3):e300-9.
doi:10.4317/jced.56324
https://doi.org/10.4317/jced.56324
____________________________________________
References
|
1.
Haffajee AD, Socransky SS, Gunsolley JC. Systemic Anti-Infective Periodontal
Therapy. A Systematic Review. Ann Periodontol. 2003;8:115-81. |
|
|
|
|
|
2.
Herrera D, Alonso B, León R, Roldán S, Sanz M. Antimicrobial therapy in
periodontitis: the use of systemic antimicrobials against the subgingival
biofilm. J Clin Periodontol. 2008;35:45-66. |
|
|
|
|
|
3.
Faggion CM, Cullinan MP, Atieh M, Wasiak J. An overview of systematic reviews
of the use of systemic antimicrobials for the treatment of periodontitis. Br
Dent J. 2014;217:443-51. |
|
|
|
|
|
4.
Sgolastra F, Gatto R, Petrucci A, Monaco A. Effectiveness of systemic
amoxicillin/metronidazole as adjunctive therapy to scaling and root planing
in the treatment of chronic periodontitis: a systematic review and meta-analysis.
J Periodontol. 2012;83:1257-69. |
|
|
|
|
|
5.
Smiley CJ, Tracy SL, Abt E, Michalowicz BS, John MT, Gunsolley J, et al.
Systematic review and meta-analysis on the nonsurgical treatment of chronic
periodontitis by means of scaling and root planing with or without adjuncts.
J Am Dent Assoc. 2015;146:508-524.e5. PMid:
26113099 |
|
|
|
|
|
6.
Jepsen K, Jepsen S. Antibiotics/antimicrobials: systemic and local
administration in the therapy of mild to moderately advanced periodontitis.
Periodontol 2000. 2016;71:82-112. |
|
|
|
|
|
7.
McGowan K, McGowan T, Ivanovski S. Optimal dose and duration of
amoxicillin-plus-metronidazole as an adjunct to non-surgical periodontal
therapy: A systematic review and meta-analysis of randomized,
placebo-controlled trials. J Clin Periodontol. 2018;45:56-67. |
|
|
|
|
|
8.
Fritoli A, GonçAlves C, Faveri M, Figueiredo LC, PéRez-Chaparro PJ, Fermiano
D, et al. The effect of systemic antibiotics administered during the active
phase of non-surgical periodontal therapy or after the healing phase: a
systematic review. J Appl Oral Sci. 2015;23:249-54. |
|
|
|
|
|
9.
Feres M. Antibiotics in the treatment of periodontal diseases: microbiological
basis and clinical applications. Ann R Australas Coll Dent Surg. 2008;19:37-44. PMid:
19728628 |
|
|
|
|
|
10.
Palmer RM, Watts TLP, Wilson RF. A double-blind trial of tetracycline in the
management of early onset periodontitis. J Clin Periodontol. 1996;23:670-4. |
|
|
|
|
|
11.
Feres M, Figueiredo LC, Soares GMS, Faveri M. Systemic antibiotics in the
treatment of periodontitis. Periodontol 2000. 2015;67:131-86. |
|
|
|
|
|
12.
Sanz M, Teughels W, Group A of European Workshop on Periodontology.
Innovations in non-surgical periodontal therapy: Consensus Report of the
Sixth European Workshop on Periodontology. J Clin Periodontol. 2008;35:3-7. |
|
|
|
|
|
13.
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for
systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535. |
|
|
|
|
|
14.
Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The
Cochrane Collaboration's tool for assessing risk of bias in randomised
trials. BMJ. 2011;343:d5928. |
|
|
|
|
|
15.
Wells G, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al. The
Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomised studies
in meta-analyses. 2014. Available from:
http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp |
|
|
|
|
|
16.
Mombelli A, Almaghlouth A, Cionca N, Cancela J, Courvoisier DS, Giannopoulou
C. Microbiologic response to periodontal therapy and multivariable prediction
of clinical outcome. J Periodontol. 2017;88:1253-62. |
|
|
|
|
|
17.
Feres M, Retamal-Valdes B, Mestnik MJ, de Figueiredo LC, Faveri M, Duarte PM,
et al. The ideal time of systemic metronidazole and amoxicillin
administration in the treatment of severe periodontitis: study protocol for a
randomized controlled trial. Trials. 2018;19:201. |
|
|
|
|
|
18.
Li Y, Xu L, Lu R, An Y, Wang X, Song W, et al. [Clinical effect of different
sequences of debridement-antibiotic therapy in treatment of severe chronic
periodontitis]. Beijing Da Xue Xue Bao. 2015;47:27-31. PMid:
25686324 |
|
|
|
|
|
19.
Lu RF, Xu L, Feng XH, Meng HX. [Short term effect of combined use of
amoxicillin and metronidazole at different time of non-surgical periodontal
treatment for aggressive periodontitis]. Zhonghua Kou Qiang Yi Xue Za Zhi.
2012;47:666-70. PMid:
23302428 |
|
|
|
|
|
20.
Giannopoulou C, Cionca N, Almaghlouth A, Cancela J, Courvoisier DS, Mombelli
A. Systemic Biomarkers in 2-Phase Antibiotic Periodontal Treatment: A
Randomized Clinical Trial. J Dent Res. 2016;95:349-55. |
|
|
|
|
|
21.
Varela VM, Heller D, Silva-Senem MX, Torres MCMB, Colombo APV, Feres-Filho
EJ. Systemic antimicrobials adjunctive to a repeated mechanical and
antiseptic therapy for aggressive periodontitis: a 6-month randomized controlled
trial. J Periodontol. 2011;82:1121-30. |
|
|
|
|
|
22.
Griffiths GS, Ayob R, Guerrero A, Nibali L, Suvan J, Moles DR, et al.
Amoxicillin and metronidazole as an adjunctive treatment in generalized
aggressive periodontitis at initial therapy or re-treatment: a randomized
controlled clinical trial. J Clin Periodontol. 2011;38:43-9. |
|
|
|
|
|
23.
Mombelli A, Almaghlouth A, Cionca N, Courvoisier DS, Giannopoulou C.
Differential Benefits of Amoxicillin-Metronidazole in Different Phases of
Periodontal Therapy in a Randomized Controlled Crossover Clinical Trial. J
Periodontol. 2015;86:367-75. |
|
|
|
|
|
24.
Kaner D, Christan C, Dietrich T, Bernimoulin JP, Kleber BM, Friedmann A.
Timing Affects the Clinical Outcome of Adjunctive Systemic Antibiotic Therapy
for Generalized Aggressive Periodontitis. J Periodontol. 2007;78:1201-8. |
|
|
|
|
|
25.
Beliveau D, Magnusson I, Bidwell JA, Zapert EF, Aukhil I, Wallet SM, et al.
Benefits of early systemic antibiotics in localized aggressive periodontitis:
a retrospective study. J Clin Periodontol. 2012;39:1075-81. |
|
|
|
|
|
26.
Guerrero A, Griffiths GS, Nibali L, Suvan J, Moles DR, Laurell L, et al.
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical
treatment of generalized aggressive periodontitis: a randomized
placebo-controlled clinical trial. J Clin Periodontol. 2005;32:1096-107. |
|
|
|
|
|
27.
Socransky SS, Haffajee AD. Dental biofilms: difficult therapeutic targets.
Periodontol 2000. 2002;28:12-55. |
|
|
|
|
|
28.
Teles RP, Haffajee AD, Socransky SS. Microbiological goals of periodontal therapy.
Periodontol 2000. 2006;42:180-218. |
|
|
|
|
|
29.
Cionca N, Giannopoulou C, Ugolotti G, Mombelli A. Amoxicillin and
metronidazole as an adjunct to full-mouth scaling and root planing of chronic
periodontitis. J Periodontol. 2009;80:364-71. |
|
|
|
|
|
30.
Cionca N, Giannopoulou C, Ugolotti G, Mombelli A. Microbiologic testing and
outcomes of full-mouth scaling and root planing with or without amoxicillin/metronidazole
in chronic periodontitis. J Periodontol. 2010;81:15-23. |
|
|
|
|
|
31.
Feres M, Soares GMS, Mendes JAV, Silva MP, Faveri M, Teles R, et al.
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment
of chronic periodontitis: a 1-year double-blinded, placebo-controlled,
randomized clinical trial. J Clin Periodontol. 2012;39:1149-58. |
|
|
|
|
|
32.
Loesche WJ, Giordano JR, Hujoel P, Schwarcz J, Smith BA. Metronidazole in
periodontitis: reduced need for surgery. J Clin Periodontol. 1992;19:103-12. |
|
|
|
|
|
33.
Loesche WJ, Giordano JR, Soehren S, Kaciroti N. The nonsurgical treatment of
patients with periodontal disease: Results after five years. J Am Dent Assoc 2002;133:311-20. |
|
|
|
|
|
34.
Mombelli A. Heresy? Treatment of chronic periodontitis with systemic
antibiotics only. J Clin Periodontol. 2006;33:661-2. |
|
|
|
|
|
35.
Mombelli A. Antimicrobial advances in treating periodontal diseases. Front
Oral Biol. 2012;15:133-48. |
|
|
|
|
|
36.
Mombelli A, Cionca N, Almaghlouth A. Does adjunctive antimicrobial therapy
reduce the perceived need for periodontal surgery? Periodontol 2000. 2011;55:205-16. |
|
|
|
|
|
37.
Silva MP, Feres M, Sirotto TAO, Soares GMS, Mendes JAV, Faveri M, et al.
Clinical and microbiological benefits of metronidazole alone or with
amoxicillin as adjuncts in the treatment of chronic periodontitis: a
randomized placebo-controlled clinical trial. J Clin Periodontol. 2011;38:828-37. |
|
|
|
|
|
38.
Mestnik MJ, Feres M, Figueiredo LC, Soares G, Teles RP, Fermiano D, et al.
The effects of adjunctive metronidazole plus amoxicillin in the treatment of
generalized aggressive periodontitis: a 1-year double-blinded,
placebo-controlled, randomized clinical trial. J Clin Periodontol. 2012;39:955-61. |
|
|
|
|
|
39.
Veloo ACM, Seme K, Raangs E, Rurenga P, Singadji Z, Wekema-Mulder G, et al.
Antibiotic susceptibility profiles of oral pathogens. Int J Antimicrob
Agents. 2012;40:450-4. |
|
|
|
|
|
40.
Ardila CM, Granada MI, Guzmán IC. Antibiotic resistance of subgingival
species in chronic periodontitis patients. J Periodontal Res. 2010;45:557-63. |
|
|
|
|
|
41.
Haffajee AD, Patel M, Socransky SS. Microbiological changes associated with
four different periodontal therapies for the treatment of chronic
periodontitis. Oral Microbiol Immunol. 2008;23:148-57. |
|
|
|
|
|
42.
Rodrigues RMJ, Gonçalves C, Souto R, Feres-Filho EJ, Uzeda M, Colombo APV.
Antibiotic resistance profile of the subgingival microbiota following
systemic or local tetracycline therapy. J Clin Periodontol. 2004;31:420-7. |
|
|
|
|
|
43.
Sedlacek MJ, Walker C. Antibiotic resistance in an in vitro subgingival
biofilm model. Oral Microbiol Immunol. 2007;22:333-9. |
|
|
|
|
|
44.
Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis:
Framework and proposal of a new classification and case definition. J
Periodontol. 2018;89:S159-72. |
|