Panneer-Selvam N, Alamoudi A, Riley III J, Katz J. Does Drug Holiday Affect Jaw Trabeculation in Medication Related Osteonecrosis of the Jaw? – A Pilot Study. J Clin Exp Dent. 2022;14(4):e341-8.

 

doi:10.4317/jced.59503

https://doi.org/10.4317/jced.59503

___________

 

References

1. Zhang X, Hamadeh IS, Song S, Katz J, Moreb JS, Langaee TY, et al. Osteonecrosis of the Jaw in the United States Food and Drug Administration's Adverse Event Reporting System (FAERS). J Bone Miner Res. 2016;31:336-40.
https://doi.org/10.1002/jbmr.2693
PMid:26288087

 

2. Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, et al. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update. J Oral Maxillofac Surg. 2014;72:1938-56.
https://doi.org/10.1016/j.joms.2014.04.031
PMid:25234529

 

3. Qi WX, Tang LN, He AN, Yao Y, Shen Z. Risk of osteonecrosis of the jaw in cancer patients receiving denosumab: a meta-analysis of seven randomized controlled trials. Int J Clin Oncol. 2014;19:403-10.
https://doi.org/10.1007/s10147-013-0561-6
PMid:23605142

 

4. Yamazaki T, Yamori M, Ishizaki T, Asai K, Goto K, Takahashi K, et al. Increased incidence of osteonecrosis of the jaw after tooth extraction in patients treated with bisphosphonates: a cohort study. Int J Oral Maxillofac Surg. 2012;41:1397-403.
https://doi.org/10.1016/j.ijom.2012.06.020
PMid:22840716

 

5. Scoletta M, Arata V, Arduino PG, Lerda E, Chiecchio A, Gallesio G, et al. Tooth extractions in intravenous bisphosphonate-treated patients: a refined protocol. J Oral Maxillofac Surg. 2013;71:994-9.
https://doi.org/10.1016/j.joms.2013.01.006
PMid:23434159

 

6. Damm DD, Jones DM. Bisphosphonate-related osteonecrosis of the jaws: a potential alternative to drug holidays. Gen Dent. 2013;61:33-8.

PMid:23928436

 

7. Diab DL, Watts NB. Bisphosphonate drug holiday: who, when and how long. Ther Adv Musculoskelet Dis. 2013;5:107-11.
https://doi.org/10.1177/1759720X13477714
PMid:23858334 PMCid:PMC3707342

 

8. Hasegawa T, Kawakita A, Ueda N, Funahara R, Tachibana A, Kobayashi M, et al. A multicenter retrospective study of the risk factors associated with medication-related osteonecrosis of the jaw after tooth extraction in patients receiving oral bisphosphonate therapy: can primary wound closure and a drug holiday really prevent MRONJ? Osteoporos Int. 2017;28:2465-73.
https://doi.org/10.1007/s00198-017-4063-7
PMid:28451732

 

9. Hellstein JW, Adler RA, Edwards B, Jacobsen PL, Kalmar JR, Koka S, et al. Managing the care of patients receiving antiresorptive therapy for prevention and treatment of osteoporosis: executive summary of recommendations from the American Dental Association Council on Scientific Affairs. J Am Dent Assoc. 2011;142:1243-51.
https://doi.org/10.14219/jada.archive.2011.0108
PMid:22041409

 

10. Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, et al. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res. 2015;30:3-23.
https://doi.org/10.1002/jbmr.2593
PMid:26390978

 

11. Gaalaas L, Henn L, Gaillard P, Ahmad M, Islam M. Analysis of trabecular bone using site-specific fractal values calculated from cone beam CT images. Oral Radiol. 2013;30:179-85.
https://doi.org/10.1007/s11282-013-0163-z

 

12. Fleisch H. Bisphosphonates in osteoporosis. In: Aebi M, Gunzburg R, Szpalski M, editors. The Aging Spine. Berlin, Heidelberg: Springer Berlin Heidelberg; 2005. p. 60-4.

 

13. Papapoulos SE, Cremers SCLM. Prolonged bisphosphonate release after treatment in children. N Engl J Med. 2007;356:1075-6.
https://doi.org/10.1056/NEJMc062792
PMid:17347467

 

14. Tofé VI, Bagán L, Bagán J V. Osteonecrosis of the jaws associated with denosumab: Study of clinical and radiographic characteristics in a series of clinical cases. J Clin Exp Dent. 2020;12:e676-81.
https://doi.org/10.4317/jced.57019
PMid:32904934 PMCid:PMC7462378

 

15. Malan J, Ettinger K, Naumann E, Beirne OR. The relationship of denosumab pharmacology and osteonecrosis of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:671-6.
https://doi.org/10.1016/j.oooo.2012.08.439
PMid:23159111

 

16. Kostenuik PJ, Nguyen HQ, McCabe J, Warmington KS, Kurahara C, Sun N, et al. Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL. J bone Miner Res Off J Am Soc Bone Miner Res. 2009;24:182-95.
https://doi.org/10.1359/jbmr.081112
PMid:19016581

 

17. Kato CN, Barra SG, Tavares NP, Amaral TM, Brasileiro CB, Mesquita RA, et al. Use of fractal analysis in dental images: a systematic review. Dentomaxillofac Radiol. 2020;49:20180457.
https://doi.org/10.1259/dmfr.20180457
PMid:31429597 PMCid:PMC7026934

 

18. González-García R, Monje F. The reliability of cone-beam computed tomography to assess bone density at dental implant recipient sites: a histomorphometric analysis by micro-CT. Clin Oral Implants Res. 2013;24:871-9.
https://doi.org/10.1111/j.1600-0501.2011.02390.x
PMid:22250839

 

19. Panmekiate S, Ngonphloy N, Charoenkarn T, Faruangsaeng T, Pauwels R. Comparison of mandibular bone microarchitecture between micro-CT and CBCT images. Dentomaxillofac Radiol. 2015;44:20140322.
https://doi.org/10.1259/dmfr.20140322
PMid:25564887 PMCid:PMC4628495

 

20. Bollen AM, Taguchi A, Hujoel PP, Hollender LG. Fractal dimension on dental radiographs. Dentomaxillofac Radiol. 2001;30:270-5.
https://doi.org/10.1038/sj.dmfr.4600630
PMid:11571547

 

21. Black DM, Schwartz A V, Ensrud KE, Cauley JA, Levis S, Quandt SA, et al. Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial. JAMA. 2006;296:2927-38.
https://doi.org/10.1001/jama.296.24.2927
PMid:17190893

 

22. Black DM, Reid IR, Boonen S, Bucci-Rechtweg C, Cauley JA, Cosman F, et al. The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis: a randomized extension to the HORIZON-Pivotal Fracture Trial (PFT). J bone Miner Res Off J Am Soc Bone Miner Res. 2012;27:243-54.
https://doi.org/10.1002/jbmr.1494
PMid:22161728 PMCid:PMC3427916

 

23. Black DM, Reid IR, Cauley JA, Cosman F, Leung PC, Lakatos P, et al. The effect of 6 versus 9 years of zoledronic acid treatment in osteoporosis: a randomized second extension to the HORIZON-Pivotal Fracture Trial (PFT). J bone Miner Res Off J Am Soc Bone Miner Res. 2015;30:934-44.
https://doi.org/10.1002/jbmr.2442
PMid:25545380

 

24. Watts NB, Chines A, Olszynski WP, McKeever CD, McClung MR, Zhou X, et al. Fracture risk remains reduced one year after discontinuation of risedronate. Osteoporos Int a J Establ as result Coop between Eur Found Osteoporos Natl Osteoporos Found USA. 2008;19:365-72.
https://doi.org/10.1007/s00198-007-0460-7
PMid:17938986