Fortea L,
Sanz-Serrano D, Luz LB, Bardini G, Mercade M. Update on chelating agents in
endodontic treatment: A systematic review. J Clin Exp Dent.
2024;16(4):e516-538.
doi:10.4317/jced.60989
https://doi.org/10.4317/jced.60989
______
References
|
1.
Cobankara FK, Erdogan H, Hamurcu M. Effects of chelating agents on the
mineral content of root canal dentin. Oral Surg Oral Med Oral Pathol Oral
Radiol Endod. 2011;112:e149-154. |
|
|
|
|
|
2.
Basrani B, Haapasalo M. Update on endodontic irrigating solutions. Endodontic
Topics. 2012;27:74-102. |
|
|
|
|
|
3.
Grawehr M, Sener B, Waltimo T, Zehnder M. Interactions of ethylenediamine
tetraacetic acid with sodium hypochlorite in aqueous solutions. Int Endod J.
2003;36:411-7. |
|
|
|
|
|
4.
Gokturk H, Ozkocak I, Buyukgebiz F. Effect of different chelating agents on
the bond strength of a silicone-based root canal sealer to root dentin. J
Conserv Dent. 2020;23:158-62. |
|
|
|
|
|
5.
Yamaguchi M, Yoshida K, Suzuki R, Nakamura H. Root canal irrigation with
citric acid solution. J Endod. 1996;22:27-9. |
|
|
|
|
|
6.
Loel DA. Use of acid cleanser in endodontic therapy. J Am Dent Assoc. 1975;90:148-51. |
|
|
|
|
|
7.
McDonnell G, Russell AD. Antiseptics and disinfectants: activity, action, and
resistance. Clin Microbiol Rev. 1999;12:147-79. |
|
|
|
|
|
8.
Ballal NV, Kandian S, Mala K, Bhat KS, Acharya S. Comparison of the efficacy
of maleic acid and ethylenediaminetetraacetic acid in smear layer removal
from instrumented human root canal: a scanning electron microscopic study. J
Endod. 2009;35:1573-6. |
|
|
|
|
|
9.
Zehnder M, Schmidlin P, Sener B, Waltimo T. Chelation in root canal therapy
reconsidered. J Endod. 2005;31:817-20. |
|
|
|
|
|
10.
Deari S, Mohn D, Zehnder M. Dentine decalcification and smear layer removal
by different ethylenediaminetetraacetic acid and
1-hydroxyethane-1,1-diphosphonic acid species. Int Endod J. 2019;52:237-43. |
|
|
|
|
|
11.
Zollinger A, Mohn D, Zeltner M, Zehnder M. Short-term storage stability of
NaOCl solutions when combined with Dual Rinse HEDP. Int Endod J. 2018;51:691-6. |
|
|
|
|
|
12.
De-Deus G, Zehnder M, Reis C, Fidel S, Fidel RAS, Galan J, et al.
Longitudinal co-site optical microscopy study on the chelating ability of
etidronate and EDTA using a comparative single-tooth model. J Endod. 2008;34:71-5. |
|
|
|
|
|
13.
Lottanti S, Gautschi H, Sener B, Zehnder M. Effects of
ethylenediaminetetraacetic, etidronic and peracetic acid irrigation on human
root dentine and the smear layer. Int Endod J. 2009;42:335-43. |
|
|
|
|
|
14.
Girard S, Paqué F, Badertscher M, Sener B, Zehnder M. Assessment of a
gel-type chelating preparation containing 1-hydroxyethylidene-1,
1-bisphosphonate. Int Endod J. 2005;38:810-6. |
|
|
|
|
|
15.
Welch V, Petticrew M, Tugwell P, Moher D, O'Neill J, Waters E, et al.
PRISMA-Equity 2012 extension: reporting guidelines for systematic reviews
with a focus on health equity. PLoS Med. 2012;9:e1001333. |
|
|
|
|
|
16.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al.
The PRISMA 2020 statement: an updated guideline for reporting systematic
reviews. BMJ. 2021;372:n71. |
|
|
|
|
|
17.
Faggion CM. Guidelines for reporting pre-clinical in vitro studies on dental
materials. J Evid Based Dent Pract. 2012;12:182-9. |
|
|
|
|
|
18.
RoB 2: A revised Cochrane risk-of-bias tool for randomized trials | Cochrane
Bias [Internet]. [cited 2023 Dec 2]. Available from:
https://methods.cochrane.org/bias/resources/rob-2-revised-cochrane-risk-bias-tool-randomized-trials |
|
|
|
|
|
19.
Ballal NV, Mala K, Bhat KS. Evaluation of the effect of maleic acid and
ethylenediaminetetraacetic acid on the microhardness and surface roughness of
human root canal dentin. J Endod. 2010;36:1385-8. |
|
|
|
|
|
20.
Ballal NV, Gandhi P, Shenoy PA, Shenoy Belle V, Bhat V, Rechenberg DK, et al.
Safety assessment of an etidronate in a sodium hypochlorite solution:
randomized double-blind trial. Int Endod J. 2019;52:1274-82. |
|
|
|
|
|
21.
Morago A, Ordinola-Zapata R, Ferrer-Luque CM, Baca P, Ruiz-Linares M,
Arias-Moliz MT. Influence of Smear Layer on the Antimicrobial Activity of a
Sodium Hypochlorite/Etidronic Acid Irrigating Solution in Infected Dentin. J
Endod. 2016;42:1647-50. |
|
|
|
|
|
22.
Paqué F, Rechenberg DK, Zehnder M. Reduction of hard-tissue debris
accumulation during rotary root canal instrumentation by etidronic acid in a
sodium hypochlorite irrigant. J Endod. 2012;38:692-5. |
|
|
|
|
|
23.
Mello I, Kammerer BA, Yoshimoto D, Macedo MCS, Antoniazzi JH. Influence of
final rinse technique on ability of ethylenediaminetetraacetic acid of
removing smear layer. J Endod. 2010;36:512-4. |
|
|
|
|
|
24.
Qian W, Shen Y, Haapasalo M. Quantitative analysis of the effect of irrigant
solution sequences on dentin erosion. J Endod. 2011;37:1437-41. |
|
|
|
|
|
25.
Ballal NV, Jain I, Tay FR. Evaluation of the smear layer removal and
decalcification effect of QMix, maleic acid and EDTA on root canal dentine. J
Dent. 2016;51:62-8. |
|
|
|
|
|
26.
Silva e Souza P a. R, das Dores RSE, Tartari T, Pinheiro TPS, Tuji FM, Silva
e Souza MH. Effects of sodium hypochlorite associated with EDTA and
etidronate on apical root transportation. Int Endod J. 2014;47:20-5. |
|
|
|
|
|
27.
Wu L, Mu Y, Deng X, Zhang S, Zhou D. Comparison of the effect of four
decalcifying agents combined with 60°C 3% sodium hypochlorite on smear layer removal.
J Endod. 2012;38:381-4. |
|
|
|
|
|
28.
Ozdemir HO, Buzoglu HD, Calt S, Cehreli ZC, Varol E, Temel A. Chemical and
ultramorphologic effects of ethylenediaminetetraacetic acid and sodium
hypochlorite in young and old root canal dentin. J Endod. 2012;38:204-8. |
|
|
|
|
|
29.
De-Deus G, Souza EM, Marins JR, Reis C, Paciornik S, Zehnder M. Smear layer
dissolution by peracetic acid of low concentration. Int Endod J. 2011;44:485-90. |
|
|
|
|
|
30.
Yılmaz Z, Aktemur S, Buzoglu HD, Gümüsderelioglu M. The effect of temperature
and pH variations on the surface tension of EDTA solutions. J Endod. 2011;37:825-7. |
|
|
|
|
|
31.
Ulusoy Öİ, Mantı AŞ, Çelik B. Nanohardness reduction and root dentine erosion
after final irrigation with ethylenediaminetetraacetic, etidronic and peracetic
acids. Int Endod J. 2020;53:1549-58. |
|
|
|
|
|
32.
Arun DR, Sujatha V, Mahalaxmi S. Effect of 5% Carbohydrate Derived-Fulvic
Acid on Smear Layer Removal and Root Dentin Microhardness - An In Vitro study.
Eur Endod J. 2022;7:156-60. PMid:35786580
PMCid:PMC9285997 |
|
|
|
|
|
33.
Prado M, Santos Júnior HM, Rezende CM, Pinto AC, Faria RB, Simão RA, et al.
Interactions between irrigants commonly used in endodontic practice: a chemical
analysis. J Endod. 2013;39:505-10. |
|
|
|
|
|
34.
Clarkson RM, Podlich HM, Moule AJ. Influence of ethylenediaminetetraacetic
acid on the active chlorine content of sodium hypochlorite solutions when
mixed in various proportions. J Endod. 2011;37:538-43. |
|
|
|
|
|
35.
Tartari T, Guimarães BM, Amoras LS, Duarte M a. H, Silva e Souza P a. R,
Bramante CM. Etidronate causes minimal changes in the ability of sodium
hypochlorite to dissolve organic matter. Int Endod J. 2015;48:399-404. |
|
|
|
|
|
36.
Wright PP, Scott S, Kahler B, Walsh LJ. Organic Tissue Dissolution in
Clodronate and Etidronate Mixtures with Sodium Hypochlorite. J Endod. 2020;46:289-94. |
|
|
|
|
|
37.
Wright PP, Kahler B, Walsh LJ. The Effect of Heating to Intracanal
Temperature on the Stability of Sodium Hypochlorite Admixed with Etidronate
or EDTA for Continuous Chelation. J Endod. 2019;45:57-61. |
|
|
|
|
|
38.
Biel P, Mohn D, Attin T, Zehnder M. Interactions between the Tetrasodium
Salts of EDTA and 1-Hydroxyethane 1,1-Diphosphonic Acid with Sodium Hypochlorite
Irrigants. J Endod. 2017;43:657-61. |
|
|
|
|
|
39.
Tartari T, Oda DF, Zancan RF, da Silva TL, de Moraes IG, Duarte M a. H, et
al. Mixture of alkaline tetrasodium EDTA with sodium hypochlorite promotes in
vitro smear layer removal and organic matter dissolution during biomechanical
preparation. Int Endod J. 2017;50:106-14. |
|
|
|
|
|
40.
Ballal NV, Moorkoth S, Mala K, Bhat KS, Hussen SS, Pathak S. Evaluation of
chemical interactions of maleic acid with sodium hypochlorite and chlorhexidine
gluconate. J Endod. 2011;37:1402-5. |
|
|
|
|
|
41.
Guerreiro-Tanomaru JM, Morgental RD, Flumignan DL, Gasparini F, Oliveira JE,
Tanomaru-Filho M. Evaluation of pH, available chlorine content, and
antibacterial activity of endodontic irrigants and their combinations against
Enterococcus faecalis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
2011;112:132-5. |
|
|
|
|
|
42.
Krishnan U, Saji S, Clarkson R, Lalloo R, Moule AJ. Free Active Chlorine in
Sodium Hypochlorite Solutions Admixed with Octenidine, SmearOFF, Chlorhexidine,
and EDTA. J Endod. 2017;43:1354-9. |
|
|
|
|
|
43.
Arias-Moliz MT, Ordinola-Zapata R, Baca P, Ruiz-Linares M, García García E,
Hungaro Duarte MA, et al. Antimicrobial activity of Chlorhexidine, Peracetic
acid and Sodium hypochlorite/etidronate irrigant solutions against
Enterococcus faecalis biofilms. Int Endod J. 2015;48:1188-93. |
|
|
|
|
|
44.
Ferrer-Luque CM, Arias-Moliz MT, González-Rodríguez MP, Baca P. Antimicrobial
activity of maleic acid and combinations of cetrimide with chelating agents
against Enterococcus faecalis biofilm. J Endod. 2010;36:1673-5. |
|
|
|
|
|
45.
Arias-Moliz MT, Morago A, Ordinola-Zapata R, Ferrer-Luque CM, Ruiz-Linares M,
Baca P. Effects of Dentin Debris on the Antimicrobial Properties of Sodium
Hypochlorite and Etidronic Acid. J Endod. 2016;42:771-5. |
|
|
|
|
|
46.
Ozdemir HO, Buzoglu HD, Calt S, Stabholz A, Steinberg D. Effect of
ethylenediaminetetraacetic acid and sodium hypochlorite irrigation on
Enterococcus faecalis biofilm colonization in young and old human root canal
dentin: in vitro study. J Endod. 2010;36:842-6. |
|
|
|
|
|
47.
Baca P, Junco P, Arias-Moliz MT, González-Rodríguez MP, Ferrer-Luque CM.
Residual and antimicrobial activity of final irrigation protocols on
Enterococcus faecalis biofilm in dentin. J Endod. 2011;37:363-6. |
|
|
|
|
|
48.
Neelakantan P, Cheng CQ, Mohanraj R, Sriraman P, Subbarao C, Sharma S.
Antibiofilm activity of three irrigation protocols activated by ultrasonic,
diode laser or Er:YAG laser in vitro. Int Endod J. 2015;48:602-10. |
|
|
|
|
|
49.
Arias-Moliz MT, Ordinola-Zapata R, Baca P, Ruiz-Linares M, Ferrer-Luque CM.
Antimicrobial activity of a sodium hypochlorite/etidronic acid irrigant solution.
J Endod. 2014;40:1999-2002. |
|
|
|
|
|
50.
Ferrer-Luque CM, Conde-Ortiz A, Arias-Moliz MT, Valderrama MJ, Baca P.
Residual activity of chelating agents and their combinations with cetrimide
on root canals infected with Enterococcus faecalis. J Endod. 2012;38:826-8. |
|
|
|
|
|
51.
Ballal NV, Das S, Rao BSS, Zehnder M, Mohn D. Chemical, cytotoxic and
genotoxic analysis of etidronate in sodium hypochlorite solution. Int Endod
J. 2019;52:1228-34. |
|
|
|
|
|
52.
Ballal NV, Kundabala M, Bhat S, Rao N, Rao BSS. A comparative in vitro
evaluation of cytotoxic effects of EDTA and maleic acid: root canal
irrigants. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:633-8. |
|
|
|
|
|
53.
Zaccaro Scelza MF, da Silva Pierro VS, Chagas MA, da Silva LE, Scelza P.
Evaluation of inflammatory response of EDTA, EDTA-T, and citric acid in animal
model. J Endod. 2010;36:515-9. |
|
|
|
|
|
54.
Viola KS, Rodrigues EM, Tanomaru-Filho M, Carlos IZ, Ramos SG, Guerreiro-Tanomaru
JM, et al. Cytotoxicity of peracetic acid: evaluation of effects on
metabolism, structure and cell death. Int Endod J. 2018;51:e264-77. |
|
|
|
|
|
55.
de Freitas JV, Ebert J, Mazzi-Chaves JF, de Sousa-Neto MD, Lohbauer U,
Baratto-Filho F. Do Contaminating Substances Influence the Rheological
Properties of Root Canal Sealers? J Endod. 2020;46:258-63. |
|
|
|
|
|
56.
Carvalho NK, Prado MC, Senna PM, Neves AA, Souza EM, Fidel SR, et al. Do
smear-layer removal agents affect the push-out bond strength of calcium silicate-based
endodontic sealers? Int Endod J. 2017;50:612-9. |
|
|
|
|
|
57.
Neelakantan P, Subbarao C, Subbarao CV, De-Deus G, Zehnder M. The impact of
root dentine conditioning on sealing ability and push-out bond strength of an
epoxy resin root canal sealer. Int Endod J. 2011;44:491-8. |
|
|
|
|
|
58.
Kara Tuncer A, Tuncer S. Effect of different final irrigation solutions on
dentinal tubule penetration depth and percentage of root canal sealer. J
Endod. 2012;38:860-3. |
|
|
|
|
|
59.
Scelza MZ, da Silva D, Scelza P, de Noronha F, Barbosa IB, Souza E, et al.
Influence of a new push-out test method on the bond strength of three
resin-based sealers. Int Endod J. 2015;48:801-6. |
|
|
|
|
|
60.
Neelakantan P, Sharma S, Shemesh H, Wesselink PR. Influence of Irrigation
Sequence on the Adhesion of Root Canal Sealers to Dentin: A Fourier Transform
Infrared Spectroscopy and Push-out Bond Strength Analysis. J Endod. 2015;41:1108-11. |
|
|
|
|
|
61.
do Prado M, de Assis DF, Gomes BPFA, Simão RA. Adhesion of resin-based
sealers to dentine: an atomic force microscopy study. Int Endod J. 2014;47:1052-7. |
|
|
|
|
|
62.
Neelakantan P, Varughese AA, Sharma S, Subbarao CV, Zehnder M, De-Deus G.
Continuous chelation irrigation improves the adhesion of epoxy resin-based
root canal sealer to root dentine. Int Endod J. 2012;45:1097-102. |
|
|
|
|
|
63.
Deniz Sungur D, Aksel H, Ozturk S, Yılmaz Z, Ulubayram K. Effect of dentine
conditioning with phytic acid or etidronic acid on growth factor release,
dental pulp stem cell migration and viability. Int Endod J. 2019;52:838-46. |
|
|
|
|
|
64.
Trevino EG, Patwardhan AN, Henry MA, Perry G, Dybdal-Hargreaves N, Hargreaves
KM, et al. Effect of irrigants on the survival of human stem cells of the
apical papilla in a platelet-rich plasma scaffold in human root tips. J
Endod. 2011;37:1109-15. |
|
|
|
|
|
65.
Ivica A, Zehnder M, Mateos JM, Ghayor C, Weber FE. Biomimetic Conditioning of
Human Dentin Using Citric Acid. J Endod. 2019;45:45-50. |
|
|
|
|
|
66.
Galler KM, Buchalla W, Hiller KA, Federlin M, Eidt A, Schiefersteiner M, et
al. Influence of root canal disinfectants on growth factor release from
dentin. J Endod. 2015;41:363-8. |
|
|
|
|
|
67.
Pang NS, Lee SJ, Kim E, Shin DM, Cho SW, Park W, et al. Effect of EDTA on
attachment and differentiation of dental pulp stem cells. J Endod. 2014;40:811-7. |
|
|
|
|
|
68.
Zeng Q, Nguyen S, Zhang H, Chebrolu HP, Alzebdeh D, Badi MA, et al. Release
of Growth Factors into Root Canal by Irrigations in Regenerative Endodontics.
J Endod. 2016;42:1760-6. |
|
|
|
|
|
69.
Liu L, Leng S, Yue J, Lu Q, Xu W, Yi X, et al. EDTA Enhances Stromal Cell-derived
Factor 1α-induced Migration of Dental Pulp Cells by Up-regulating Chemokine
Receptor 4 Expression. J Endod. 2019;45:599-605. |
|
|
|
|
|
70.
Taweewattanapaisan P, Jantarat J, Ounjai P, Janebodin K. The Effects of EDTA
on Blood Clot in Regenerative Endodontic Procedures. J Endod. 2019;45:281-6. |
|
|
|
|
|
71.
Rossi-Fedele G, Doğramaci EJ, Guastalli AR, Steier L, de Figueiredo JAP.
Antagonistic interactions between sodium hypochlorite, chlorhexidine, EDTA,
and citric acid. J Endod. 2012;38:426-31. |
|
|
|
|
|
72.
Pisarenko AN, Stanford BD, Quiñones O, Pacey GE, Gordon G, Snyder SA. Rapid
analysis of perchlorate, chlorate and bromate ions in concentrated sodium
hypochlorite solutions. Anal Chim Acta. 2010;659:216-23. |
|
|
|
|
|
73.
Eswaranandam S, Hettiarachchy NS, Johnson MG. Antimicrobial Activity of Citric,
Lactic, Malic, or Tartaric Acids and Nisin-incorporated Soy Protein Film
Against Listeria monocytogenes, Escherichia coli O157:H7, and Salmonella
gaminara. Journal of Food Science. 2004;69:FMS79-84. |
|
|
|
|
|
74.
Lottanti S, Gautschi H, Sener B, Zehnder M. Effects of
ethylenediaminetetraacetic, etidronic and peracetic acid irrigation on human
root dentine and the smear layer. Int Endod J. 2009;42:335-43. |
|
|
|
|
|
75.
Chávez de Paz LE, Bergenholtz G, Dahlén G, Svensäter G. Response to alkaline
stress by root canal bacteria in biofilms. Int Endod J. 2007;40:344-55. |
|
|
|
|
|
76.
Baureder M, Reimann R, Hederstedt L. Contribution of catalase to hydrogen
peroxide resistance in Enterococcus faecalis. FEMS Microbiol Lett. 2012;331:160-4. |
|
|
|
|
|
77.
Marending M, Luder HU, Brunner TJ, Knecht S, Stark WJ, Zehnder M. Effect of
sodium hypochlorite on human root dentine--mechanical, chemical and
structural evaluation. Int Endod J. 2007;40:786-93. |
|
|
|
|
|
78.
Prado M, Simão RA, Gomes BPFA. Effect of different irrigation protocols on
resin sealer bond strength to dentin. J Endod. 2013;39:689-92. |
|
|
|
|
|
79.
Doucet J, Zhao A, Fu J, Avrameas A. Development and validation of an ELISA at
acidic pH for the quantitative determination of IL-13 in human plasma and
serum. Dis Markers. 2013;35:465-74. |
|