Espejo-Carrera
RE, Asmat-Abanto AS, Honores MJC, Alvarado JAC. Effectiveness of mouthwashes to
reduce the SARS-COV-2 load in saliva of adults with diagnosis of COVID-19:
Systematic review and meta-analysis. J Clin Exp Dent. 2025;17(1):e96-107.
doi:10.4317/jced.62196
https://doi.org/10.4317/jced.62196
___
References
1. Hernández-Vásquez A,
Barrenechea-Pulache A, Comandé D, Azañedo D. Mouthrinses and SARS-CoV-2 viral
load in saliva: a living systematic review. Evid Based Dent. 2022;24:1-7. |
|
|
|
2. Mezarina Mendoza JPI, Trelles
Ubillús BP, Salcedo Bolívar GT, Castañeda Palacios RDP, Herrera Lopez PSG,
Padilla Rodríguez DA, et al. Antiviral effect of mouthwashes against SARS-COV-2:
A systematic review. Saudi Dent J. 2022;34(3):167-93. |
|
|
|
3. Seneviratne CJ, Balan P, Ko
KKK, Udawatte NS, Lai D, Ng DHL, et al. Efficacy of commercial mouth-rinses
on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore.
Infection. 2021;49(2):305-11. |
|
|
|
4. García-Sánchez A,
Peña-Cardelles JF, Ruiz S, Robles F, Ordonez-Fernandez E, Salgado-Peralvo AO,
et al. Efficacy of Pre-Procedural Mouthwashes against SARS-CoV-2: A
Systematic Review of Randomized Controlled Trials. J Clin Med.
2022;11(6):1692. |
|
|
|
5. Ferrer MD, Barrueco ÁS,
Martinez-Beneyto Y, Mateos-Moreno MV, Ausina-Márquez V, García-Vázquez E, et
al. Clinical evaluation of antiseptic mouth rinses to reduce salivary load of
SARS-CoV-2. Sci Rep. 2021;11(1):24392. |
|
|
|
6. Tadakamadla J, Boccalari E,
Rathore V, Dolci C, Tartaglia GM, Tadakamadla SK. In vitro studies evaluating
the efficacy of mouth rinses on Sars-Cov-2: A systematic review. J Infect
Public Health. 2021;14(9):1179-85. |
|
|
|
7. D'Amico F, Moro M, Saracino M,
Marmiere M, Cilona MB, Lloyd-Jones G, Zangrillo A. Efficacy of
Cetylpyridinium Chloride mouthwash against SARS-CoV-2: A systematic review of
randomized controlled trials. Mol Oral Microbiol. 2023;38(3):171-80. |
|
|
|
8. Elzein R, Abdel-Sater F,
Fakhreddine S, Hanna PA, Feghali R, Hamad H, et al. In vivo evaluation of the
virucidal efficacy of chlorhexidine and povidone-iodine mouthwashes against
salivary SARS-CoV-2. A randomized-controlled clinical trial. J Evid Based
Dent Pract. 2021;21(3):101584. |
|
|
|
9. Silva A, Azevedo M,
Sampaio-Maia B, Sousa-Pinto B. The effect of mouthrinses on severe acute
respiratory syndrome coronavirus 2 viral load: A systematic review. J Am Dent
Assoc. 2022;153(7):635-48.e16. |
|
|
|
10. Adl A, Sedigh-Shams M,
Jamalidoust M, Rajabzadeh Z. Evaluating the effect of gargling with hydrogen
peroxide and povidone-iodine on salivary viral load of SARS-CoV-2: A pilot
randomized clinical trial. Niger J Clin Pract. 2023;26(4):391-6. |
|
|
|
11. Gandhi G, Thimmappa L, Upadhya
N, Carnelio S. Could mouth rinses be an adjuvant in the treatment of
SARS-CoV-2 patients? An appraisal with a systematic review. Int J Dent Hyg.
2022;20(1):136-44. |
|
|
|
12. Cavalcante-Leão BL, de Araujo
CM, Basso IB, Schroder AG, Guariza-Filho O, Ravazzi GC, et al. Is there
scientific evidence of the mouthwashes effectiveness in reducing viral load
in Covid-19? A systematic review. J Clin Exp Dent. 2021;13(2):e179-89. |
|
|
|
13. Carrouel F, Valette M, Gadea
E, Esparcieux A, Illes G, Langlois ME, et al. Use of an antiviral mouthwash
as a barrier measure in the SARS-CoV-2 transmission in adults with
asymptomatic to mild COVID-19: a multicentre, randomized, double-blind
controlled trial. Clin Microbiol Infect. 2021;27(10):1494-501. |
|
|
|
14. Rahman GS, Alshetan AAN,
Alotaibi SSO, Alaskar BMI, Baseer MA. Is chlorhexidine mouthwash effective in
lowering COVID-19 viral load? A systematic review. Eur Rev Med Pharmacol Sci.
2023;27(1):366-77. |
|
|
|
15. Pannuti CM, Reis INRD, Souza
NV, Souto MLS, Silva CGB, Bezinelli LM, et al. Efficacy of mouthrinses in
reducing oral SARS-COV-2 load: a review. Braz Oral Res. 2023;37:e038. |
|
|
|
16. Page MJ, Moher D, Bossuyt PM,
Boutron I, Hoffmann TC, Mulrow CD, et al. PRISMA 2020 explanation and
elaboration: updated guidance and exemplars for reporting systematic reviews.
BMJ. 2021;372(160):n160. |
|
|
|
17. Mourad Ouzzani, Hossam
Hammady, Zbys Fedorowicz, and Ahmed Elmagarmid. Rayyan - a web and mobile app
for systematic reviews. Systematic Reviews (2016) 5:210. |
|
|
|
18. Sterne JAC, Savović J, Page
MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for
assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. |
|
|
|
19. GRADEpro Guideline Development
Tool [Software]. McMaster University and Evidence Prime, 2024. Available from
gradepro.org. |
|
|
|
20. Page MJ, McKenzie JE, Bossuyt
PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an
updated guideline for reporting systematic reviews. BMJ 2021;372:n71. |
|
|
|
21. Farmaha JK, James JN, Frazier
K, Sahajpal NS, Mondal AK, Bloomquist DT, et al. Reduction of SARS-CoV-2
salivary viral load with pre-procedural mouth rinses: a randomised,
controlled, clinical trial. Br Dent J. 2023;234(8):593-600. |
|
|
|
22. Sánchez Barrueco Á,
Mateos-Moreno MV, Martínez-Beneyto Y, García-Vázquez E, Campos González A,
Zapardiel Ferrero J, et al. Effect of oral antiseptics in reducing SARS-CoV-2
infectivity: evidence from a randomized double-blind clinical trial. Emerg Microbes
Infect. 2022;11(1):1833-42. |
|
|
|
23. Chaudhary P, Melkonyan A,
Meethil A, Saraswat S, Hall DL, Cottle J, et al. Estimating salivary carriage
of severe acute respiratory syndrome coronavirus 2 in nonsymptomatic people
and efficacy of mouthrinse in reducing viral load: A randomized controlled
trial. J Am Dent Assoc. 2021;152(11):903-08. |
|
|
|
24. Eduardo FP, Corrêa L, Heller
D, Daep CA, Benitez C, Malheiros Z, et al. Salivary SARS-CoV-2 load reduction
with mouthwash use: A randomized pilot clinical trial. Heliyon.
2021;7(6):e07346. |
|
|
|
25. Fantozzi PJ, Pampena E,
Pierangeli A, Oliveto G, Sorrentino L, Di Vanna D, et al. Efficacy of
antiseptic mouthrinses against SARS-CoV-2: A prospective randomized
placebo-controlled pilot study. Am J Otolaryngol. 2022;43(6):103549. |
|
|
|
26. Natto ZS, Bakhrebah MA, Afeef
M, Al-Harbi S, Nassar MS, Alhetheel AF, et al. The short-term effect of
different chlorhexidine forms versus povidone iodine mouth rinse in
minimizing the oral SARS-CoV-2 viral load: An open label randomized
controlled clinical trial study. Medicine (Baltimore). 2022;101(30):e28925. |
|
|
|
27. Alzahrani MM, Bamashmous S,
Alkharobi H, Alghamdi A, Alharbi RH, Hassan AM, et al. Mouth rinses efficacy
on salivary SARS-CoV-2 viral load: A randomized clinical trial. J Med Virol.
2023;95(1):e28412. |
|
|
|
28. Alemany A, Perez-Zsolt D,
Raïch-Regué D, et al. Cetylpyridinium Chloride Mouthwash to Reduce Shedding
of Infectious SARS-CoV-2: A Double-Blind Randomized Clinical Trial. Journal
of Dental Research. 2022;101(12):1450-56. |
|
|
|
29. Costa D, Brites C, Vaz S, de
Santana D, dos Santos J, Cury P. Chlorhexidine Mouthwash reduces the salivary
viral load of SARS-CoV-2: a randomized clinical trial. Oral Diseases.
2022;28(Suppl. 2):2500-08. |
|
|
|
30. Sevinç Gül SN, Dilsiz A,
Sağlık İ, Aydın NN. Effect of oral antiseptics on the viral load of
SARS-CoV-2: A randomized controlled trial. Dent Med Probl. 2022;59(3):357-63. |
|
|
|
31. Tarragó-Gil R, Gil-Mosteo MJ,
Aza-Pascual-Salcedo M, Alvarez MJL, Ainaga RR, Gimeno NL, Viñuales RF,
Fernández YM, Marco JM, Bolsa EA, Sancho JB, Cajo SA, Perez-Zsolt D,
Raïch-Regué D, Muñoz-Basagoiti J, Izquierdo-Useros N, Pociello VB, León R,
Peris DS. Randomized clinical trial to assess the impact of oral intervention
with cetylpyridinium chloride to reduce salivary SARS-CoV-2 viral load. J
Clin Periodontol. 2023;50(3):288-94. |
|
|
|
32. Sánchez Barrueco A,
Mateos-Moreno MV, Villacampa Aubá JM, Campos González A, Bogoya Castaño A,
Rubio Yanguas R, et al. In vivo effect of mouthwashes on viable viral load of
SARS-CoV-2 in saliva: a pilot study. J Oral Microbiol. 2023;15(1):2198432. |
|
|
|
33. Lin SY, Sun JS, Hung MC, Chang
JZ. Effectiveness of mouth rinses against COVID-19: a systematic review and
network meta-analysis. J Hosp Infect. 2023;139:175-91. |
|
|
|
34. Ziaeefar P, Bostanghadiri N,
Yousefzadeh P, Gabbay J, Shahidi Bonjar AH, Ghazizadeh Ahsaie M, et al. The
efficacy of mouthwashes in reducing SARS-CoV-2 viral loads in human saliva: A
systematic review. New Microbes New Infect. 2022;49:101064. |
|
|
|
35. Ting M, Dahlkemper A, Schwartz
JJ, Woodfork M, Suzuki JB. Preprocedural Viral Load Effects of Oral
Antiseptics on SARS-CoV-2 in Patients with COVID-19: A Systematic Review.
Biomedicines. 2023;11(6):1694. |
|
|
|
36. Zhang M, Meng N, Duo H, Yang
Y, Dong Q, Gu J. Efficacy of mouthwash on reducing salivary SARS-CoV-2 viral
load and clinical symptoms: a systematic review and meta-analysis. BMC Infect
Dis. 2023;23(1):678. |
|
|
|
37. Hasan F, Chiu HY, Salamanca E,
Ridwan ES, Wiratama BS, Budi HS. Effects of Chlorhexidine and Povidone-Iodine
on the SARS-CoV-2 Load: A Systematic Review and Meta-analysis. Eur J Dent.
2023;17(3):587-601. |
|
|
|
38. Ebrahimi T, Shamshiri AR,
Alebouyeh M, Mohebbi SZ. Effectiveness of mouthwashes on reducing SARS-CoV-2
viral load in oral cavity: a systematic review and meta-analysis. BMC Oral
Health. 2023;23(1):443. |
|
|
|
39. Sbricoli L, Schiavon L,
Brunello G, Brun P, Becker K, Sivolella S. Efficacy of different mouthwashes
against COVID-19: A systematic review and network meta-analysis. Jpn Dent Sci
Rev. 2023;59:334-56. |
|
|
|
40. Fernández MDS, Guedes MIF,
Langa GPJ, Rösing CK, Cavagni J, Muniz FWMG. Virucidal efficacy of
chlorhexidine: a systematic review. Odontology. 2022;110(2):376-92. |