Gurgel B, Souza R, Vajgel A, Cabral MF, Almeida M, Almeida R. Are Dyslipidemias a risk factor for Peri-Implant complications? A Systematic review and meta-analysis. J Clin Exp Dent. 2025;17(4):e461-73.

 

doi:10.4317/jced.62241

https://doi.org/10.4317/jced.62241

___

 

References

1. Ustaoglu G, Erdal E. Relationship between risk markers for cardiovascular disease and peri-implant diseases. Int J Implant Dent. 2020;25;6:1:73.
https://doi.org/10.1186/s40729-020-00273-z
PMid:33236168 PMCid:PMC7686405

 

2. Mayta-Tovalino F, Mendoza-Martiarena Y, Romero-Tapia P, Álvarez-Paucar M, Gálvez-Calla L, Calderón-Sánchez J, et al. An 11-Year Retrospective Research Study of the Predictive Factors of Peri-Implantitis and Implant Failure: Analytic-Multicentric Study of 1279 Implants in Peru. Int J Dent. 2019;1-8.
https://doi.org/10.1155/2019/3527872
PMid:31341478 PMCid:PMC6612967

 

3. Marchio V, Derchi G, Cinquini C, Miceli M, Gabriele M, Alfonsi F, et al. Tissue level implants in healthy versus medically compromised patients: a cohort comparative study. Minerva Stomatol. 2020;69:5:295-301.
https://doi.org/10.23736/S0026-4970.20.04359-9
PMid:32407061

 

4. Tekin MB, Toker H. The effect of hyperlipidemia on bone graft regeneration of peri-implantal created defects in rabbits. Int J Implant Dent. 2019; 15:5:1:18.
https://doi.org/10.1186/s40729-019-0170-x
PMid:31089911 PMCid:PMC6517464

 

5. Alsaadi G, Quirynen M, Michiles K, Teughels W, Komárek A, Van Steenberghe D. Impact of local and systemic factors on the incidence of failures up to abutment connection with modified surface oral implants. J Clin Periodontol. 2008;35:1:51-7.
https://doi.org/10.1111/j.1600-051X.2007.01165.x
PMid:18034851

 

6. Thim T, Scholz KJ, Hiller KA, Buchalla W, Kirschneck C, Fleiner J, et al. Radiographic bone loss and its relation to patient-specific risk factors, LDL cholesterol, and vitamin D: a cross-sectional study. Nutrients. 2022;14:864.
https://doi.org/10.3390/nu14040864
PMid:35215516 PMCid:PMC8877125

 

7. Keuroghlian A, Barroso AD, Kirikian G, Bezouglaia O, Tintut Y, Tetradis S, et al. The effects of hyperlipidemia on implant osseointegration in the mouse femur. J Oral Implantol. 2015;41:2:7-11.
https://doi.org/10.1563/AAID-JOI-D-13-00105
PMid:24295508 PMCid:PMC4465368

 

8. Ballard-Hernandez J, Sall J. Dyslipidemia update. Nurs Clin North Am. 2023;58:3:295-308.
https://doi.org/10.1016/j.cnur.2023.05.002
PMid:37536782

 

9. Sun H, Meng S, Chen J, Wan Q. Effects of hyperlipidemia on osseointegration of dental implants and its strategies. J Funct Biomater. 2023;14:4:194.
https://doi.org/10.3390/jfb14040194
PMid:37103284 PMCid:PMC10145040

 

10. Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editors. Cochrane Handbook for Systematic Reviews of Interventions. Version 6.4. Cochrane; 2023.

 

11. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;29:372:71.
https://doi.org/10.1136/bmj.n71
PMid:33782057 PMCid:PMC8005924

 

12. Tufanaru C, Munn Z, Aromataris E, Campbell J, Hopp L. Chapter 3: Systematic reviews of effectiveness. In: Aromataris E, Munn Z (Editors). JBI Manual for Evidence Synthesis. JBI, 2020.
https://doi.org/10.46658/JBIRM-17-03
PMCid:PMC7891321

 

13. Lang NP, Berglundh T; Working Group 4 of Seventh European Workshop on Periodontology. Peri-implant diseases: where are we now?--Consensus of the Seventh European Workshop on Periodontology. J Clin Periodontol. 2011;38:11:178-81.
https://doi.org/10.1111/j.1600-051X.2010.01674.x
PMid:21323713

 

14. GRADEpro GDT: GRADEpro guideline development tool [Software]. McMaster University (developed by Evidence Prime, Inc.; 2020.

 

15. Schünemann HJ, Oxman AD, Brozek J, Glasziou P, Jaeschke R, Vist GE, et al. GRADE Working Group. Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ. 2008;17:336:7653:1106-10.
https://doi.org/10.1136/bmj.39500.677199.AE
PMid:18483053 PMCid:PMC2386626

 

16. Schumemann H., Brożek J., Guyatt G, Oxman, A. GRADE Handbook. Grading of Recommendations Assessment, Development and Evaluation, Grade Working Group. 2013.

 

17. Tirone F, Salzano S, D'orsi L, Paola P, Rodi D. Is a high level of total cholesterol a risk factor for dental implants or bone grafting failure? A retrospective cohort study on 227 patients. Eur J Oral Implantol. 2016;9:1:77-84.

PMid:27022639

 

18. Vohra F, Alkhudhairy F, Al-Kheraif AA, Akram Z, Javed F. Peri-implant parameters and C-reactive protein levels among patients with different obesity levels. Clin Implant Dent Relat Res. 2018;20:2:130-136.
https://doi.org/10.1111/cid.12556
PMid:29148260

 

19. Alves LB, Coelho TDRC, de Azevedo RA, Dos Santos JN, Neves FS, Cury PR. Systemic risk indicators for peri-implant diseases in individuals with implant-supported fixed prostheses: A cross-sectional study. Int J Oral Implantol (Berl). 2020;13:3:255-266.

PMid:32879930

 

20. Di Murro B, Papi P, Letizia C, Pompa G. The prevalence of peri-implant diseases in patients with metabolic syndrome: a case-control study on an Italian population sample. Minerva Stomatol. 2019;68:4:143-149.
https://doi.org/10.23736/S0026-4970.19.04243-2
PMid:31357847

 

21. Papi P, Letizia C, Pilloni A, Petramala L, Saracino V, Rosella D et al. Peri-implant diseases and metabolic syndrome components: a systematic review. Eur Rev Med Pharmacol Sci. 2018;22:4:866-875.

PMid:29509232

 

22. Alkhudhairy F, Vohra F, Al-Kheraif AA, Akram Z. Comparison of clinical and radiographic peri-implant parameters among obese and non-obese patients: A 5-year study. Clin Implant Dent Relat Res. 2018;20:5:756-762.
https://doi.org/10.1111/cid.12633
PMid:30028553

 

23. Blanco C, Liñares A, Dopico J, Pico A, Sobrino T, Leira Y et al. Peri-implantitis, systemic inflammation, and dyslipidemia: a cross-sectional biochemical study. J Periodontal Implant Sci. 2021;51:5:342-351.
https://doi.org/10.5051/jpis.2100920046
PMid:34713995 PMCid:PMC8558006

 

24. Berglundh T, Armitage G, Araujo MG, Avila-Ortiz G, Blanco J, Camargo PM et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol. 2018;20:286-291.

PMid:29926491

 

25. Fentoglu O, Bozkurt FY. The Bi-Directional Relationship between Periodontal Disease and Hyperlipidemia. Eur J Dent. 2008;2:2:142-6.
https://doi.org/10.1055/s-0039-1697370
PMid:19212526 PMCid:PMC2633171

 

26. Choukroun J, Khoury G, Khoury F, Russe P, Testori T, Komiyama Y, et al. Two neglected biologic risk factors in bone grafting and implantology: high low-density lipoprotein cholesterol and low serum vitamin D. J Oral Implantol. 2014;40:1:110-4.
https://doi.org/10.1563/AAID-JOI-D-13-00062
PMid:24107195

 

27. Tomofuji T, Ekuni D, Azuma T, Irie K, Endo Y, Kasuyama K, et al. Involvement of toll-like receptor 2 and 4 in association between dyslipidemia and osteoclast differentiation in apolipoprotein E deficient rat periodontium. Lipids Health Dis. 2013;12:1:1-6.
https://doi.org/10.1186/1476-511X-12-1
PMid:23295061 PMCid:PMC3599925

 

28. During A, Penel G, Hardouin P. Understanding the local actions of lipids in bone physiology. Prog Lipid Res. 2015;59:126-46.
https://doi.org/10.1016/j.plipres.2015.06.002
PMid:26118851

 

29. Mandal CC. High Cholesterol Deteriorates Bone Health: New Insights into Molecular Mechanisms. Front Endocrinol (Lausanne). 2015;23:6:165.
https://doi.org/10.3389/fendo.2015.00165
PMid:26557105 PMCid:PMC4617053

 

30. Monteiro JLGC, Pellizzer EP, Araújo Lemos CA, de Moraes SLD, do Egito Vasconcelos BC. Is there an association between overweight/obesity and dental implant complications? A systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2019;48:9:1241-1249.
https://doi.org/10.1016/j.ijom.2019.01.015
PMid:30792086

 

31. Gorman A, Kaye EK, Apovian C, Fung TT, Nunn M, Garcia RI. Overweight and obesity predict time to periodontal disease progression in men. J Clin Periodontol. 2012;39:2):107-14.
https://doi.org/10.1111/j.1600-051X.2011.01824.x
PMid:22150475 PMCid:PMC3258330

 

32. Nepomuceno R, Pigossi SC, Finoti LS, Orrico SRP, Cirelli JA, Barros SP, et al. Serum lipid levels in patients with periodontal disease: A meta-analysis and meta-regression. J Clin Periodontol. 2017;44:12:1192-1207.
https://doi.org/10.1111/jcpe.12792
PMid:28782128

 

33. Naseri R, Yaghini J, Feizi A. Levels of smoking and dental implants failure: A systematic review and meta-analysis. J Clin Periodontol. 2020;47:4:518-528.
https://doi.org/10.1111/jcpe.13257
PMid:31955453