Verma S, Gupta A, Mrinalini M, Abraham D, Soma U. Comparative Evaluation of Autologous Platelet Aggregates Versus Blood Clot On The Outcome Of Regenerative Endodontic Therapy: A Systematic Review and Meta-Analysis. J Clin Exp Dent. 2025;17(4):e447-60.

 

doi:10.4317/jced.62508

https://doi.org/10.4317/jced.62508

___

 

References

1. Alothman FA, Hakami LS, Alnasser A, AlGhamdi FM, Alamri AA, Almutairii BM. Recent Advances in Regenerative Endodontics: A Review of Current Techniques and Future Directions. Cureus. 2024;16(11):e74121.
https://doi.org/10.7759/cureus.74121

PMid:39712709 PMCid:PMC11662148

 

2. Gawthaman M, Vinodh S, Mathian VM, Vijayaraghavan R, Karunakaran R. Apexification with calcium hydroxide and mineral trioxide aggregate: Report of two cases. J Pharm Bioallied Sci. 2013;5(Suppl 2):S131-4.
https://doi.org/10.4103/0975-7406.114305
PMid:23956590 PMCid:PMC3740659

 

3. N, Revathi, Sharath SM. Merits and Demerits of Calcium Hydroxide as a Therapeutic Agent: A Review. Int J Dent Sci Res. 2014;2:1-4.
https://doi.org/10.12691/ijdsr-2-6B-1

 

4. Lee BN, Moon JW, Chang HS, Hwang IN, Oh WM, Hwang YC. A review of the regenerative endodontic treatment procedure. Restor Dent Endod. 2015;40(3):179-87.
https://doi.org/10.5395/rde.2015.40.3.179
PMid:26295020 PMCid:PMC4534721

 

5. Parirokh M, Torabinejad M. Mineral trioxide aggregate: a comprehensive literature review--Part III: Clinical applications, drawbacks, and mechanism of action. J Endod. 2010;36(3):400-13.
https://doi.org/10.1016/j.joen.2009.09.009
PMid:20171353

 

6. Geisler TM. Clinical considerations for regenerative endodontic procedures. Dent Clin North Am. 2012;56(3):603-26.
https://doi.org/10.1016/j.cden.2012.05.010
PMid:22835541

 

7. Liu H, Lu J, Jiang Q, Haapasalo M, Qian J, Tay FR, et al. Biomaterial scaffolds for clinical procedures in endodontic regeneration. Bioact Mater. 2021;12:257-77.
https://doi.org/10.1016/j.bioactmat.2021.10.008
PMid:35310382 PMCid:PMC8897058

 

8. Gathani KM, Raghavendra SS. Scaffolds in regenerative endodontics: A review. Dent Res J (Isfahan). 2016;13(5):379-86.
https://doi.org/10.4103/1735-3327.192266
PMid:27857762 PMCid:PMC5090995

 

9. Panda S, Mishra L, Arbildo-Vega HI, Lapinska B, Lukomska-Szymanska M, Khijmatgar S, et al. Effectiveness of autologous platelet concentrates in management of young immature necrotic permanent teeth: A systematic review and meta-analysis. Cells. 2020;9(10):2241.
https://doi.org/10.3390/cells9102241
PMid:33036462 PMCid:PMC7600252

 

10. Tang Q, Jin H, Lin S, Ma L, Tian T, Qin X. Are platelet concentrate scaffolds superior to traditional blood clot scaffolds in regeneration therapy of necrotic immature permanent teeth? A systematic review and meta-analysis. BMC Oral Health. 2022;22(1):589.
https://doi.org/10.1186/s12903-022-02605-4
PMid:36494711 PMCid:PMC9733063

 

11. Ulusoy AT, Turedi I, Cimen M, Cehreli ZC. Evaluation of blood clot, platelet-rich plasma, platelet-rich fibrin, and platelet pellet as scaffolds in regenerative endodontic treatment: A prospective randomized trial. J Endod. 2019;45(5):560-566.
https://doi.org/10.1016/j.joen.2019.02.002
PMid:30935618

 

12. ElSheshtawy AS, Nazzal H, El Shahawy OI, El Baz AA, Ismail SM, Kang J, et al. The effect of platelet-rich plasma as a scaffold in regeneration/revitalization endodontics of immature permanent teeth assessed using 2-dimensional radiographs and cone beam computed tomography: A randomized controlled trial. Int Endod J. 2020;53(7):905-921.
https://doi.org/10.1111/iej.13303
PMid:32249441

 

13. Shivashankar VY, Johns DA, Maroli RK, Sekar M, Chandrasekaran R, Karthikeyan S, et al. Comparison of the effect of PRP, PRF, and induced bleeding in the revascularization of teeth with necrotic pulp and open apex: A triple blind randomized clinical trial. J Clin Diagn Res. 2017;11(6):ZC34-ZC39.
https://doi.org/10.7860/JCDR/2017/22352.10056
PMid:28765825 PMCid:PMC5534513

 

14. Mittal N, Baranwal HC, Kumar P, Gupta S. Assessment of pulp sensibility in mature necrotic teeth using regenerative endodontic therapy with various scaffolds: A randomized clinical trial. Indian J Dent Res. 2021;32(2):216-220.
https://doi.org/10.4103/ijdr.ijdr_253_21
PMid:34810392

 

15. Ragab RA, Lattif AEAE, Dokky NAEWE. Comparative study between revitalization of necrotic immature permanent anterior teeth with and without platelet-rich fibrin: A randomized controlled trial. J Clin Pediatr Dent. 2019;43:78-85.
https://doi.org/10.17796/1053-4625-43.2.2
PMid:30730794

 

16. Uppala S. A comparative evaluation of PRF, blood clot, and collagen scaffold in regenerative endodontics. Eur J Mol Clin Med. 2020;7(2):3401-10.

 

17. Bezgin T, Yilmaz AD, Celik BN, Kolsuz ME, Sonmez H. Efficacy of platelet-rich plasma as a scaffold in regenerative endodontic treatment. J Endod. 2015;41(1):36-44.
https://doi.org/10.1016/j.joen.2014.10.004
PMid:25459571

 

18. Alagl A, Bedi S, Hassan K, AlHumaid J. Use of platelet-rich plasma for regeneration in non-vital immature permanent teeth: Clinical and cone-beam computed tomography evaluation. J Int Med Res. 2017;45:583-93.
https://doi.org/10.1177/0300060517692935
PMid:28415948 PMCid:PMC5536665

 

19. Rizk HM, Al-Deen MSS, Emam AA. Regenerative endodontic treatment of bilateral necrotic immature permanent maxillary central incisors with platelet-rich plasma versus blood clot: A split mouth double-blinded randomized controlled trial. Int J Clin Pediatr Dent. 2019;12(4):332-339.
https://doi.org/10.5005/jp-journals-10005-1656
PMid:31866720 PMCid:PMC6898871

 

20. Rizk HM, Salah Al-Deen MS, Emam AA. Pulp revascularization/revitalization of bilateral upper necrotic immature permanent central incisors with blood clot vs platelet-rich fibrin scaffolds: A split-mouth double-blind randomized controlled trial. Int J Clin Pediatr Dent. 2020;13(4):337-343.
https://doi.org/10.5005/jp-journals-10005-1788
PMid:33149405 PMCid:PMC7586471

 

21. Youssef A, Ali M, ElBolok A, Hassan R. Regenerative endodontic procedures for the treatment of necrotic mature teeth: A preliminary randomized clinical trial. Int Endod J. 2022;55(4):334-346.
https://doi.org/10.1111/iej.13681
PMid:35030270

 

22. Ramachandran N, Singh S, Podar R, Kulkarni G, Shetty R, Chandrasekhar P. A comparison of two pulp revascularization techniques using platelet-rich plasma and whole blood clot. J Conserv Dent. 2020;23(6):637-643.
https://doi.org/10.4103/JCD.JCD_221_20
PMid:34083923 PMCid:PMC8095687

 

23. Narang I, Mittal N, Mishra N. A comparative evaluation of blood clot, platelet-rich plasma, and platelet-rich fibrin in regeneration of necrotic immature permanent teeth: A clinical study. Contemp Clin Dent 2015;6:63-8.
https://doi.org/10.4103/0976-237X.149294
PMid:25684914 PMCid:PMC4319348

 

24. Sharma S, Mittal N. A comparative evaluation of natural and artificial scaffolds in regenerative endodontics: A clinical study. Saudi Endod J. 2016;6(1):9-15.
https://doi.org/10.4103/1658-5984.171995

 

25. Jadhav G, Shah N, Logani A. Revascularization with and without platelet-rich plasma in nonvital, immature, anterior teeth: A pilot clinical study. J Endod. 2012;38(12):1581-7.
https://doi.org/10.1016/j.joen.2012.09.010
PMid:23146641

 

26. Meschi N, EzEldeen M, Garcia AET, Lahoud P, Van Gorp G, Coucke W, et al. Regenerative endodontic procedure of immature permanent teeth with leukocyte and platelet-rich fibrin: A multicenter controlled clinical trial. J Endod. 2021;47(11):1729-1750.
https://doi.org/10.1016/j.joen.2021.08.003
PMid:34400199

 

27. Lv H, Chen Y, Cai Z, Lei L, Zhang M, Zhou R, et al. The efficacy of platelet-rich fibrin as a scaffold in regenerative endodontic treatment: A retrospective controlled cohort study. BMC Oral Health. 2018;18(1):139.
https://doi.org/10.1186/s12903-018-0598-z
PMid:30103724 PMCid:PMC6090610

 

28. Yang F, Yu L, Li J, Cheng J, Zhang Y, Zhao X, et al. Evaluation of concentrated growth factor and blood clot as scaffolds in regenerative endodontic procedures: A retrospective study. Aust Endod J. 2023;49(2):332-343.
https://doi.org/10.1111/aej.12666
PMid:35877114

 

29. Nagaveni NB, Poornima P, Mathew MG, Soni AJ, Khan MM. A comparative evaluation of revascularization done in traumatized immature necrotic anterior teeth with and without platelet-rich fibrin: A case report. Int J Clin Pediatr Dent. 2020;13(1):98-102.
https://doi.org/10.5005/jp-journals-10005-1738
PMid:32581489 PMCid:PMC7299885

 

30. Van Le H, Nguyen TA, Vu TS. Regenerative endodontic procedures of immature permanent premolars with periapical lesions: A report of two cases using two different materials, 18-month follow-up. Case Rep Dent. 2023;2023:5577474.
https://doi.org/10.1155/2023/5577474
PMid:38020963 PMCid:PMC10681770

 

31. Pulyodan MK, Paramel Mohan S, Valsan D, Divakar N, Moyin S, Thayyil S. Regenerative endodontics: A paradigm shift in clinical endodontics. J Pharm Bioallied Sci. 2020;12(Suppl 1):S20-S26.
https://doi.org/10.4103/jpbs.JPBS_112_20
PMid:33149426 PMCid:PMC7595546

 

32. Ding ZY, Tan Y, Peng Q, Zuo J, Li N. Novel applications of platelet concentrates in tissue regeneration (Review). Exp Ther Med. 2021;21(3):226.
https://doi.org/10.3892/etm.2021.9657
PMid:33603835 PMCid:PMC7851614

 

33. Rahul M, Lokade A, Tewari N, Mathur V, Agarwal D, Goel S, et al. Effect of intracanal scaffolds on the success outcomes of regenerative endodontic therapy - A systematic review and network meta-analysis. J Endod. 2023;49(2):110-128.
https://doi.org/10.1016/j.joen.2022.11.011
PMid:36410623

 

34. Wilkinson HN, Hardman MJ. Wound healing: cellular mechanisms and pathological outcomes. Open Biol. 2020;10(9):200223.
https://doi.org/10.1098/rsob.200223
PMid:32993416 PMCid:PMC7536089

 

35. Kim SG, Malek M, Sigurdsson A, Lin LM, Kahler B. Regenerative endodontics: a comprehensive review. Int Endod J. 2018;51(12):1367-1388.
https://doi.org/10.1111/iej.12954
PMid:29777616

 

36. Ríos-Osorio N, Caviedes-Bucheli J, Jimenez-Peña O, Orozco-Agudelo M, Mosquera-Guevara L, Jiménez-Castellanos FA, et al. Comparative outcomes of platelet concentrates and blood clot scaffolds for regenerative endodontic procedures: A systematic review of randomized controlled clinical trials. J Clin Exp Dent. 2023;15(3):e239-e249.
https://doi.org/10.4317/jced.60150
PMid:37008236 PMCid:PMC10062460

 

37. Huidobro-Guerrero AA, Santoy-Lozano A, Lopez-Martinez F, Garcia-Jau RA, Valle-Urias AE, Nakagoshi-Cepeda SE, et al. Autologous platelet concentrates in regenerative endodontic treatment. Int J Appl Dent Sci. 2021;7(4):20-24.
https://doi.org/10.22271/oral.2021.v7.i4a.1347

 

38. Castro-Gutiérrez MEM, Argueta-Figueroa L, Fuentes-Mascorro G, Moreno-Rodríguez A, Torres-Rosas R. Novel approaches for the treatment of necrotic immature teeth using regenerative endodontic procedures: a systematic review and meta-analysis. Appl Sci. 2021;11:5199.
https://doi.org/10.3390/app11115199