Huang SH, O´Sullivan B. Oral cancer: Current role of radiotherapy and chemotherapy. Med Oral Patol Oral Cir Bucal. 2013 Mar 1;18 (2):e233-40. 

 

 

doi:10.4317/medoral.18772

http://dx.doi.org/doi:10.4317/medoral.18772

 

 

 

1. Bessell A, Glenny AM, Furness S, Clarkson JE, Oliver R, Conway DI, et al. Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment. Cochrane Database Syst Rev. 2011;9:CD006205.
PMid:21901703

 

2. Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, et al. Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck. 2005;27:843-50.
http://dx.doi.org/10.1002/hed.20279
PMid:16161069

 

3. Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004;350:1937-44.
http://dx.doi.org/10.1056/NEJMoa032646
PMid:15128893

 

4. Shrime MG, Gullane PJ, Dawson L, Kim J, Gilbert RW, Irish JC, et al. The impact of adjuvant radiotherapy on survival in T1-2N1 squamous cell carcinoma of the oral cavity. Arch Otolaryngol Head Neck Surg. 2010;136:225-8.
http://dx.doi.org/10.1001/archoto.2010.22
PMid:20231637

 

5. Peters LJ, Goepfert H, Ang KK, Byers RM, Maor MH, Guillamondegui O, et al. Evaluation of the dose for postoperative radiation therapy of head and neck cancer: first report of a prospective randomized trial. Int J Radiat Oncol Biol Phys. 1993;26:3-11.
http://dx.doi.org/10.1016/0360-3016(93)90167-T

 

6. Langendijk JA, Slotman BJ, van der Waal I, Doornaert P, Berkof J, Leemans CR. Risk-group definition by recursive partitioning analysis of patients with squamous cell head and neck carcinoma treated with surgery and postoperative radiotherapy. Cancer. 2005;104:1408-1417.
http://dx.doi.org/10.1002/cncr.21340
PMid:16130134

 

7. Brown JS, Shaw RJ, Bekiroglu F, Rogers SN. Systematic review of the current evidence in the use of postoperative radiotherapy for oral squamous cell carcinoma. Br J Oral Maxillofac Surg. 2012;50:481-489.
http://dx.doi.org/10.1016/j.bjoms.2011.08.014
PMid:22196145

 

8. Huang TY, Hsu LP, Wen YH, Huang TT, Chou YF, Lee CF, et al. Predictors of locoregional recurrence in early stage oral cavity cancer with free surgical margins. Oral Oncol. 2010;46:49-55.
http://dx.doi.org/10.1016/j.oraloncology.2009.10.011
PMid:20005769

 

9. Liao CT, Chang JT, Wang HM, Ng SH, Hsueh C, Lee LY, et al. Does adjuvant radiation therapy improve outcomes in pT1-3N0 oral cavity cancer with tumor-free margins and perineural invasion? Int J Radiat Oncol Biol Phys. 2008;71:371-6.
http://dx.doi.org/10.1016/j.ijrobp.2007.10.015
PMid:18474310

 

10. Huang SH, Hwang D, Lockwood G, Goldstein DP, O'Sullivan B. Predictive value of tumor thickness for cervical lymph-node involvement in squamous cell carcinoma of the oral cavity: a meta-analysis of reported studies. Cancer. 2009;115:1489-1497.
http://dx.doi.org/10.1002/cncr.24161
PMid:19197973

 

11. Liao CT, Lin CY, Fan KH, Wang HM, Ng SH, Lee LY, et al. Identification of a high-risk group among patients with oral cavity squamous cell carcinoma and pT1-2N0 disease. Int J Radiat Oncol Biol Phys. 2012;82:284-90.
http://dx.doi.org/10.1016/j.ijrobp.2010.09.036
PMid:21075550

 

12. Moergel M, Jahn-Eimermacher A, Krummenauer F, Reichert TE, Wagner W, Wendt TG, et al. Effectiveness of adjuvant radiotherapy in patients with oropharyngeal and floor of mouth squamous cell carcinoma and concomitant histological verification of singular ipsilateral cervical lymph node metastasis (pN1-state)--a prospective multicenter randomized controlled clinical trial using a comprehensive cohort design. Trials. 2009;10:118.
http://dx.doi.org/10.1186/1745-6215-10-118
PMid:20028566 PMCid:2804680

 

13. Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefčbvre JL, Greiner RH, et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 2004;350:1945-52.
http://dx.doi.org/10.1056/NEJMoa032641
PMid:15128894

 

14. Cooper JS, Pajak TF, Forastiere A, Jacobs J, Fu KK, Ang KK, et al. Precisely defining high-risk operable head and neck tumors based on RTOG #85-03 and #88-24: targets for postoperative radiochemotherapy? Head Neck.1998;20:588-94.
http://dx.doi.org/10.1002/(SICI)1097-0347(199810)20:7<588::AID-HED2>3.0.CO;2-F

 

15. Fan KH, Wang HM, Kang CJ, Lee LY, Huang SF, Lin CY, et al. Treatment results of postoperative radiotherapy on squamous cell carcinoma of the oral cavity: coexistence of multiple minor risk factors results in higher recurrence rates. Int J Radiat Oncol Biol Phys. 2010;77:1024-9.
http://dx.doi.org/10.1016/j.ijrobp.2009.06.064
PMid:20610038

 

16. Liao CT, Chang JT, Wang HM, Ng SH, Hsueh C, Lee LY, et al. Analysis of risk factors of predictive local tumor control in oral cavity cancer. Ann Surg Oncol. 2008;15:915-22.
http://dx.doi.org/10.1245/s10434-007-9761-5
PMid:18165878

 

17. Parsons JT, Mendenhall WM, Stringer SP, Cassisi NJ, Million RR. An analysis of factors influencing the outcome of postoperative irradiation for squamous cell carcinoma of the oral cavity. Int J Radiat Oncol Biol Phys. 1997;39:137-48.
http://dx.doi.org/10.1016/S0360-3016(97)00152-1

 

18. Looser KG, Shah JP, Strong EW. The significance of "positive" margins in surgically resected epidermoid carcinomas. Head Neck Surg. 1978;1:107-111.
http://dx.doi.org/10.1002/hed.2890010203
PMid:755803

 

19. Batsakis JG. Surgical excision margins: a pathologist's perspective. Adv Anat Pathol. 1999;6:140-148.
http://dx.doi.org/10.1097/00125480-199905000-00002
PMid:10342011

 

20. Binahmed A, Nason RW, Abdoh AA. The clinical significance of the positive surgical margin in oral cancer. Oral Oncol. 2007;43:780-784.
http://dx.doi.org/10.1016/j.oraloncology.2006.10.001
PMid:17174145

 

21. Chen PY, Chen HH, Hsiao JR, Yang MW, Hsueh WT, Tasi ST, et al. Intensity-modulated radiotherapy improves outcomes in postoperative patients with squamous cell carcinoma of the oral cavity. Oral Oncol. 2012;48:747-52.
http://dx.doi.org/10.1016/j.oraloncology.2012.02.010
PMid:22401870

 

22. Guillemaud JP, Patel RS, Goldstein DP, Higgins KM, Enepekides DJ. Prognostic impact of intraoperative microscopic cut-through on frozen section in oral cavity squamous cell carcinoma. J Otolaryngol Head Neck Surg. 2010;39:370-7.
PMid:20643001

 

23. Huang J, Barbera L, Brouwers M, Browman G, Mackillop WJ. Does delay in starting treatment affect the outcomes of radiotherapy? A systematic review. J Clin Oncol. 2003;21:555-63.
http://dx.doi.org/10.1200/JCO.2003.04.171
PMid:12560449

 

24. Daly ME, Le QT, Kozak MM, Maxim PG, Murphy JD, Hsu A, et al. Intensity-modulated radiotherapy for oral cavity squamous cell carcinoma: patterns of failure and predictors of local control. Int J Radiat Oncol Biol Phys. 2011;80:1412-22.
http://dx.doi.org/10.1016/j.ijrobp.2010.04.031
PMid:20675073

 

25. Langendijk JA, de Jong MA, Leemans CR, de Bree R, Smeele LE, Doornaert P, et al. Postoperative radiotherapy in squamous cell carcinoma of the oral cavity: the importance of the overall treatment time. Int J Radiat Oncol Biol Phys. 2003;57:693-700.
http://dx.doi.org/10.1016/S0360-3016(03)00624-2

 

26. Studer G, Zwahlen RA, Graetz KW, Davis BJ, Glanzmann C. IMRT in oral cavity cancer. Radiat Oncol. 2007;2:16.
http://dx.doi.org/10.1186/1748-717X-2-16
PMid:17430599 PMCid:1855346

 

27. Murthy V, Agarwal JP, Laskar SG, Gupta T, Budrukkar A, Pai P, et al. Analysis of prognostic factors in 1180 patients with oral cavity primary cancer treated with definitive or adjuvant radiotherapy. J Cancer Res Ther. 2010;6:282-9.
http://dx.doi.org/10.4103/0973-1482.73360
PMid:21119254

 

28. Cohen EE, Baru J, Huo D, Haraf DJ, Crowley M, Witt ME, Blair EA, Weichselbaum RR, Rosen F, Vokes EE, Stenson K. Efficacy and safety of treating T4 oral cavity tumors with primary chemoradiotherapy. Head Neck. 2009;31:1013-21.
http://dx.doi.org/10.1002/hed.21062
PMid:19340870

 

29. Pignon JP, le Maître A, Maillard E, Bourhis J. MACH-NC Collaborative Group. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol. 2009;92:4-14.
http://dx.doi.org/10.1016/j.radonc.2009.04.014
PMid:19446902

 

30. Bourhis J, Overgaard J, Audry H, Ang KK, Saunders M, Bernier J, et al. Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis. Lancet. 2006;368:843-54.
http://dx.doi.org/10.1016/S0140-6736(06)69121-6

 

31. Mazeron JJ, Ardiet JM, Haie-Méder C, Kovács G, Levendag P, Peiffert D, et al. GEC-ESTRO recommendations for brachytherapy for head and neck squamous cell carcinomas. Radiother Oncol. 2009;91:150-6.
http://dx.doi.org/10.1016/j.radonc.2009.01.005
PMid:19329209

 

32. Chakrabarti B, Ghorai S, Basu B, Ghosh SK, Gupta P, Ghosh K, et al. Late nodal metastasis in early-stage node-negative oral cavity cancers after successful sole interstitial brachytherapy: an institutional experience of 42 cases in India. Brachytherapy. 2010;9:254-9.
http://dx.doi.org/10.1016/j.brachy.2009.11.001
PMid:20226741

 

33. Grabenbauer GG, Rödel C, Brunner T, Schulze-Mosgau S, Strnad V, Müller RG, et al. Interstitial brachytherapy with Ir-192 low-dose-rate in the treatment of primary and recurrent cancer of the oral cavity and oropharynx. Review of 318 patients treated between 1985 and 1997. Strahlenther Onkol. 2001;177:338-44.
http://dx.doi.org/10.1007/PL00002416
PMid:11505619

 

34. Do L, Puthawala A, Syed N. Interstitial brachytherapy as boost for locally advanced T4 head and neck cancer. Brachytherapy. 2009;8:385-91.
http://dx.doi.org/10.1016/j.brachy.2009.03.191
PMid:19733128

 

35. Patra NB, Goswami J, Basu S, Chatterjee K, Sarkar SK. Outcomes of high dose rate interstitial boost brachytherapy after external beam radiation therapy in head and neck cancer--an Indian (single institutional) learning experience. Brachytherapy. 2009;8:248-54.
http://dx.doi.org/10.1016/j.brachy.2008.12.006
PMid:19230791

 

36. Chatani M, Tsuboi K, Yagi M, Fujiwara K, Tachimoto R, Yoshioka H. High dose rate brachytherapy using molds after chemoradiotherapy for oral cavity cancer. Jpn J Radiol. 2012;30:40-4.
http://dx.doi.org/10.1007/s11604-011-0005-z
PMid:22160650

 

37. Lapeyre M, Bollet MA, Racadot S, Geoffrois L, Kaminsky MC, Hoffstetter S, et al. Postoperative brachytherapy alone and combined postoperative radiotherapy and brachytherapy boost for squamous cell carcinoma of the oral cavity, with positive or close margins. Head Neck. 2004;26:216-23.
http://dx.doi.org/10.1002/hed.10377
PMid:14999796

 

38. Grimard L, Esche B, Lamothe A, Cygler J, Spaans J. Interstitial low-dose-rate brachytherapy in the treatment of recurrent head and neck malignancies. Head Neck. 2006;28:888-95.
http://dx.doi.org/10.1002/hed.20422
PMid:16721742

 

39. Grimard L, Esche B, Lamothe A, Spaans JN. Interstitial brachytherapy in the management of persistent head and neck disease after definitive external beam radiation therapy. Brachytherapy. 2009;8:284-9.
http://dx.doi.org/10.1016/j.brachy.2008.12.007
PMid:19446500

 

40. Mazeron JJ, Noël G, Simon JM. Head and neck brachytherapy. Semin Radiat Oncol. 2002;12:95-108.
http://dx.doi.org/10.1053/srao.2002.28668
PMid:11813154

 

41. Huang SF, Cheng SD, Chien HT, Liao CT, Chen IH, Wang HM, et al. Relationship between epidermal growth factor receptor gene copy number and protein expression in oral cavity squamous cell carcinoma. Oral Oncol. 2012;48:67-72.
http://dx.doi.org/10.1016/j.oraloncology.2011.06.511
PMid:21831696

 

42. Chen IH, Chang JT, Liao CT, Wang HM, Hsieh LL, Cheng AJ. Prognostic significance of EGFR and Her-2 in oral cavity cancer in betel quid prevalent area cancer prognosis. Br J Cancer. 2003;89:681-6.
http://dx.doi.org/10.1038/sj.bjc.6601171
PMid:12915878

 

43. Wheeler S, Siwak DR, Chai R, LaValle C, Seethala RR, Wang L, et al. Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma. Clin Cancer Res. 2012;18:2278-89.
http://dx.doi.org/10.1158/1078-0432.CCR-11-1593
PMid:22351687

 

44. Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354:567-78. 45. Bhide SA, Ahmed M, Newbold K, Harrington KJ, Nutting CM. The role of intensity modulated radiotherapy in advanced oral cavity carcinoma. J Cancer Res Ther. 2012;8 Suppl 1:S67-71.

 

46. Sher DJ, Thotakura V, Balboni TA, Norris CM, Haddad RI, Posner MR, et al. Treatment of oral cavity squamous cell carcinoma with adjuvant or definitive intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2011;81:e215-22.
http://dx.doi.org/10.1016/j.ijrobp.2011.02.023
PMid:21531515

 

47. Tsai CJ, Hofstede TM, Sturgis EM, Garden AS, Lindberg ME, Wei Q, et al. Osteoradionecrosis and radiation dose to the mandible in patients with oropharyngeal cancer. Int J Radiat Oncol Biol Phys. 2013;85:415-20.
http://dx.doi.org/10.1016/j.ijrobp.2012.05.032
PMid:22795804

 

48. Balogh JM, Sutherland SE. Osteoradionecrosis of the mandible: a review. J Otolaryngol. 1989;18:245-50.
PMid:2671406

 

49. Monnier Y, Broome M, Betz M, Bouferrache K, Ozsahin M, Jaques B. Mandibular osteoradionecrosis in squamous cell carcinoma of the oral cavity and oropharynx: incidence and risk factors. Otolaryngol Head Neck Surg. 2011;144:726-32.
http://dx.doi.org/10.1177/0194599810396290
PMid:21493361

 

50. O'Sullivan B, Rumble RB, Warde P, Members of the IMRT Indications Expert Panel. Intensity-modulated radiotherapy in the treatment of head and neck cancer. Clin Oncol (R Coll Radiol). 2012;24:474-87.
http://dx.doi.org/10.1016/j.clon.2012.05.006
PMid:22770590

 

51. Ben-David MA, Diamante M, Radawski JD, Vineberg KA, Stroup C, Murdoch-Kinch CA, et al. Lack of osteoradionecrosis of the mandible after intensity-modulated radiotherapy for head and neck cancer: likely contributions of both dental care and improved dose distributions. Int J Radiat Oncol Biol Phys. 2007;68:396-402.
http://dx.doi.org/10.1016/j.ijrobp.2006.11.059
PMid:17321069 PMCid:2702207

 

52. Studer G, Studer SP, Zwahlen RA, Huguenin P, Grätz KW, Lütolf UM, et al. Osteoradionecrosis of the mandible: minimized risk profile following intensity-modulated radiation therapy (IMRT). Strahlenther Onkol. 2006;182:283-8.
http://dx.doi.org/10.1007/s00066-006-1477-0
PMid:16673062

 

53. Little M, Schipper M, Feng FY, Vineberg K, Cornwall C, Murdoch-Kinch CA, et al. Reducing xerostomia after chemo-IMRT for head-and-neck cancer: beyond sparing the parotid glands. Int J Radiat Oncol Biol Phys. 2012;83:1007-14.
PMid:22056067

 

54. Chen WC, Hwang TZ, Wang WH, Lu CH, Chen CC, Chen CM, et al. Comparison between conventional and intensity-modulated post-operative radiotherapy for stage III and IV oral cavity cancer in terms of treatment results and toxicity. Oral Oncol. 2009;45:505-10. 55. Mishra RC, Singh DN, Mishra TK. Post-operative radiotherapy in carcinoma of buccal mucosa, a prospective randomized trial. Eur J Surg Oncol. 1996;22:502-4.

 

55. Mishra RC, Singh DN, Mishra TK. Post-operative radiotherapy in carcinoma of buccal mucosa, a prospective randomized trial. Eur J Surg Oncol. 1996;22:502-4.
http://dx.doi.org/10.1016/S0748-7983(96)92969-8