Rubio-Palau J, Garcia-Linares J, Hueto-Madrid JA, González-Lagunas J, Raspall-Martin G, Mareque-Bueno J. Effect of intra-alveolar placement of 0.2% chlorhexidine bioadhesive gel on the incidence of alveolar osteitis following the extraction of mandibular third molars. A double-blind randomized clinical trial. Med Oral Patol Oral Cir Bucal. 2015 Jan 1;20 (1):e117-22.

doi:10.4317/medoral.20009

http://dx.doi.org/doi:10.4317/medoral.20009

1. Blum IR, Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review. Int J Oral Maxillofac Surg. 2002;31:309-17.
http://dx.doi.org/10.1054/ijom.2002.0263

2. Caso A, Hung LK, Beirne OR. Prevention of alveolar osteitis with chlorhexidine: a meta-analytic review Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:155-9.
http://dx.doi.org/10.1016/j.tripleo.2004.05.009

3. Hermesch CB, Hilton TJ, Biesbrock AR, Baker RA, Cain-Hamlin J, McClanahan SF, et al. Perioperative use of 0.12% chlorhexidine gluconate for the prevention of alveolar osteitis: efficacy and risk factor analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85:381-7.
http://dx.doi.org/10.1016/S1079-2104(98)90061-0

4. Ren YF, Malmstrom HS. Effectiveness of Antibiotic Prophylaxis in Third Molar Surgery: A Meta-Analysis of Randomized Controlled Clinical Trials. J Oral Maxillofac Surg. 2007;65:1909-1921.
http://dx.doi.org/10.1016/j.joms.2007.03.004

5. Zeitler DL. Prophylactic antibiotics for third molar surgery: a dissenting opinion. J Oral Maxillofac Surg. 1995;53:61-4.
http://dx.doi.org/10.1016/0278-2391(95)90503-0

6. Haraji A, Lassemi E, Motamedi MH, Alavi M, Adibnejad S. Effect of plasma rich in growth factors on alveolar osteitis. Natl J Maxillofac Surg. 2012;3:38-41.
http://dx.doi.org/10.4103/0975-5950.102150

7. Berwick JE, Lessin ME. Effects of a chlorhexidine gluconate oral rinse on the incidence of alveolar osteitis in mandibular third molar surgery. J Oral Maxillofac Surg. 1990;48:444-8.
http://dx.doi.org/10.1016/0278-2391(90)90227-S

8. Larsen PE. The effect of a chlorhexidine rinse on the incidence of alveolar osteitis following the surgical removal of impacted mandibular third molars. J Oral Maxillofac Surg. 1991;49:932-7.
http://dx.doi.org/10.1016/0278-2391(91)90055-Q

9. Tjernberg A. Influence of oral hygiene measures on the development of alveolitis sicca dolorosa after surgical removal of mandibular third molars. Int J Oral Surg. 1979;8:430-4.
http://dx.doi.org/10.1016/S0300-9785(79)80081-2

10. Bonine FL. Effect of chlorhexidine rinse on the incidence of dry socket in impacted mandibular third molar extraction sites. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79:154-7.
http://dx.doi.org/10.1016/S1079-2104(05)80273-2

11. Ragno JR, Szkutnik AJ. Evaluation of 0.12% chlorhexidine rinse on the prevention of alveolar osteitis. Oral Surg Oral Med Oral Pathol. 1991;72:524-6.
http://dx.doi.org/10.1016/0030-4220(91)90487-W

12. Torres-Lagares D, Gutierrez-Perez JL, Infante-Cossio P, Garcia-Calderon M, Moreno-Ruiz MM, Serrera-Figallo MA. Randomized, double-blind study on effectiveness of intra-alveolar chlorhexidine gel in reducing the incidence of alveolar osteitis in mandibular third molar surgery. Int J Oral Maxillofac Surg. 2006;35:348-51.
http://dx.doi.org/10.1016/j.ijom.2005.08.002

13. Hita-Iglesias P, Torres-Lagares D, Flores-Ruiz R, Magallanes-Abad N, Basallote-Gonzalez M, Gutierrez-Perez JL. Effectiveness of chlorhexidine gel versus chlorhexidine rinse in reducing alveolar osteitis in mandibular third molar surgery. J Oral Maxillofac Surg. 2008;66:441-5.
http://dx.doi.org/10.1016/j.joms.2007.06.641

14. Haraji A, Rakhshan V, Khamverdi N, Alishahi HK. Effects of intra-alveolar placement of 0.2% chlorhexidine bioadhesive gel on dry socket incidence and postsurgical pain: a double-blind split-mouth randomized controlled clinical trial. J Orofac Pain. 2013;27:256-62.
http://dx.doi.org/10.11607/jop.1142

15. Torres-Lagares D, Gutierrez-Perez JL, Hita-Iglesias P, Magallanes-Abad N, Flores-Ruiz R, Basallote-Garcia M, et al. Randomized, double-blind study of effectiveness of intra-alveolar application of chlorhexidine gel in reducing incidence of alveolar osteitis and bleeding complications in mandibular third molar surgery in patients with bleeding disorders. J Oral Maxillofac Surg. 2010;68:1322-6.
http://dx.doi.org/10.1016/j.joms.2009.08.022

16. Torres-Lagares, D, Infante-Cossio P, Gutierrez-Perez JL, Romero-Ruiz MM, Garcia-Calderon M, Serrera-Figallo MA. Intra-alveolar chlorhexidine gel for the prevention of dry socket in mandibular third molar surgery. A pilot study. Med Oral Patol Oral Cir Bucal. 2006;11:E179-84.

17. Rodriguez-Perez M, Bravo-Pérez M, Sánchez-López JD, Mu-oz-Soto E, Romero-Olid MN, Baca-García P. Effectiveness of 1% versus 0.2% chlorhexidine gels in reducing alveolar osteitis from mandibular third molar surgery: A randomized, double-blind clinical trial. Med Oral Patol Oral Cir Bucal. 2013;18:e693-700.
http://dx.doi.org/10.4317/medoral.18702

18. Metin M, Tek M, Sener I. Comparison of two chlorhexidine rinse protocols on the incidence of alveolar osteitis following the surgical removal of impacted third molars. J Contemp Dent Pract. 2006;7:79-86.

19. Daly B, Sharif MO, Newton T, Jones K, Worthington HV. Local interventions for the management of alveolar osteitis (dry socket). Cochrane Database Syst Rev. 2012;12:CD006968.

20. Yengopal V, Mickenautsch S. Chlorhexidine for the prevention of alveolar osteitis. Int J Oral Maxillofac Surg. 2012;41:1253-64.
http://dx.doi.org/10.1016/j.ijom.2012.04.017

21. Richards D. Does chlorhexidine prevent dry socket?. Evid Based Dent. 2012;13:91.
http://dx.doi.org/10.1038/sj.ebd.6400882

22. Delilbasi C, Saracoglu U, Keskin A. Effects of 0.2% chlorhexidine gluconate and amoxicillin plus clavulanic acid on the prevention of alveolar osteitis following mandibular third molar extractions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94:301-4.
http://dx.doi.org/10.1067/moe.2002.125200

23. Chapnick P, Diamond LH. A review of dry socket: a double-blind study on the effectiveness of clindamycin in reducing the incidence of dry socket. J Can Dent Assoc. 1992;58:43-52.