Yong-Deok K, Eun-Hyoung J, Yeon-Sun K, Kang-Mi P, Jin-Yong L, Sung-Hwan C, Tae-Yun K, Tae-Sung P, Soung-Min K, Myung-Jin K, Jong-Ho L. Molecular genetic study of novel biomarkers for early diagnosis of oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 2015 Mar 1;20 (2):e167-79.  

 

 

doi:10.4317/medoral.20229

http://dx.doi.org/doi:10.4317/medoral.20229

 

 

 

1. Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol. 2001;2:533-43.
http://dx.doi.org/10.1016/S1470-2045(01)00486-7

 

2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71-96.
http://dx.doi.org/10.3322/CA.2007.0010

 

3. da Silva SD, Ferlito A, Takes RP, Brakenhoff RH, Valentin MD, Woolgar JA, et al. Advances and applications of oral cancer basic research. Oral Oncol. 2011;47:783-91.
http://dx.doi.org/10.1016/j.oraloncology.2011.07.004

 

4. Sandler HC. Cytological screening for early mouth cancer. Cancer. 1962;15:1119-24.
http://dx.doi.org/10.1002/1097-0142(196211/12)15:6<1119::AID-CNCR2820150605>3.0.CO;2-A

 

5. Al-Sarraf M. Chemotherapeutic management of head and neck cancer. Cancer Metastasis Rev. 1987;6:181-98.
http://dx.doi.org/10.1007/BF00144263

 

6. Rao SK, Pavicevic Z, Du Z, Kim JG, Fan M, Jiao Y, et al. Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma. J Biol Chem. 2010; 285:32512-21.
http://dx.doi.org/10.1074/jbc.M110.150490

 

7. Ziober AF, Patel KR, Alawi F, Gimotty P, Weber RS, Feldman MM, et al. Identification of a gene signature for rapid screening of oral squamous cell carcinoma. Clin Cancer Res. 2006;12:5960-71.
http://dx.doi.org/10.1158/1078-0432.CCR-06-0535

 

8. Reis PP, Waldron L, Perez-Ordonez B, Pintilie M, Galloni NN, Xuan Y, et al. A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence. BMC Cancer. 2011;11:437.
http://dx.doi.org/10.1186/1471-2407-11-437

 

9. Zhao J, Rycaj K, Geng S, Li M, Plummer JB, Yin B, et al. Expression of Human Endogenous Retrovirus Type K Envelope Protein is a Novel Candidate Prognostic Marker for Human Breast Cancer. Genes Cancer. 2011;2:914-22.
http://dx.doi.org/10.1177/1947601911431841

 

10. Jain N, Thatte J, Braciale T, Ley K, O'Connell M, Lee JK. Local-pooled-error test for identifying differentially expressed genes with a small number of replicated microarrays. Bioinformatics. 2003;19:1945-51.
http://dx.doi.org/10.1093/bioinformatics/btg264

 

11. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci. 2001;98:5116-21.
http://dx.doi.org/10.1073/pnas.091062498

 

12. Lockstone HE. Exon array data analysis using Affymetrix power tools and R statistical software. Brief Bioinform. 2011;12:634-44.
http://dx.doi.org/10.1093/bib/bbq086

 

13. Shapiro SS, Wilk MB. An analysis of variance test for normality (complete samples). Biometrika. 1965;52:591-611.
http://dx.doi.org/10.1093/biomet/52.3-4.591

 

14. Dürkop H, Latza U, Hummel M, Eitelbach F, Seed B, Stein H. Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. Cell. 1992;68:421-7.
http://dx.doi.org/10.1016/0092-8674(92)90180-K

 

15. Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, et al. Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas. J Biol Chem. 1996;271:19402-8.
http://dx.doi.org/10.1074/jbc.271.32.19402

 

16. Bassuny WM, Ihara K, Kimura J, Ichikawa S, Kuromaru R, Miyako K, et al. Association study between interleukin-12 receptor beta1/beta2 genes and type 1 diabetes or asthma in the Japanese population. Immunogenetics. 2003;55:189-92.
http://dx.doi.org/10.1007/s00251-003-0568-7

 

17. Harris MJ, Arias IM. FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body. Biochim Biophys Acta. 2003;1633:127-31.
http://dx.doi.org/10.1016/S1388-1981(03)00107-0

 

18. Tenca P, Brotherton D, Montagnoli A, Rainoldi S, Albanese C, Santocanale C. Cdc7 is an active kinase in human cancer cells undergoing replication stress. J Biol Chem. 2007;282:208-15.
http://dx.doi.org/10.1074/jbc.M604457200

 

19. Zhong JL, Poghosyan Z, Pennington CJ, Scott X, Handsley MM, Warn A, et al. Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma. Mol Cancer Res. 2008;6:383-94.
http://dx.doi.org/10.1158/1541-7786.MCR-07-2028

 

20. Menéndez ST, Rodrigo JP, Allonca E, García-Carracedo D, Alvarez-Alija G, Casado-Zapico S, et al. Expression and clinical significance of the Kv3.4 potassium channel subunit in the development and progression of head and neck squamous cell carcinomas. J Pathol. 2010;221:402-10.

 

21. Kuwano Y, Kamio Y, Kawai T, Katsuura S, Inada N, Takaki A, et al. Autism-associated gene expression in peripheral leucocytes commonly observed between subjects with autism and healthy women having autistic children. PloS one. 2011;6:e24723.
http://dx.doi.org/10.1371/journal.pone.0024723

 

22. Marenholz I, Rivera VA, Esparza-Gordillo J, Bauerfeind A, Lee-Kirsch MA, Ciechanowicz A, et al. Association screening in the Epidermal Differentiation Complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema. J Invest Dermatol. 2011;131:1644-9.
http://dx.doi.org/10.1038/jid.2011.90

 

23. Oliver AW, He X, Borthwick K, Donne AJ, Hampson L, Hampson IN. The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42. Br J Cancer. 2011;104:324-31.
http://dx.doi.org/10.1038/sj.bjc.6606026

 

24. Lenain C, Bauwens S, Amiard S, Brunori M, Giraud-Panis MJ, Gilson E. The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair. Curr Biol. 2006;16:1303-10.
http://dx.doi.org/10.1016/j.cub.2006.05.021

 

25. Pettus JR, Johnson JJ, Shi Z, Davis JW, Koblinski J, Ghosh S, et al. Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity. Histol Histopathol. 2009;24:197-207.

 

26. Supic G, Kozomara R, Jovic N, Zeljic K, Magic Z. Prognostic significance of tumor-related genes hypermethylation detected in cancer-free surgical margins of oral squamous cell carcinomas. Oral Oncol. 2011;47:702-8.
http://dx.doi.org/10.1016/j.oraloncology.2011.05.014

 

27. Ahn SM, Kim TH, Lee S, Kim D, Ghang H, Kim DS, et al. The first Korean genome sequence and analysis: full genome sequencing for a socio-ethnic group. Genome Res. 2009;19:1622-9.
http://dx.doi.org/10.1101/gr.092197.109

 

28. Cheong SC, Chandramouli GV, Saleh A, Zain RB, Lau SH, Sivakumaren S, et al. Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure. Oral Oncol. 2009;45:712-9.
http://dx.doi.org/10.1016/j.oraloncology.2008.11.002

 

29. Méndez E, Cheng C, Farwell DG, Ricks S, Agoff SN, Futran ND, et al. Transcriptional expression profiles of oral squamous cell carcinomas. Cancer. 2002;95:1482-94.
http://dx.doi.org/10.1002/cncr.10875

 

30. Chen C, Méndez E, Houck J, Fan W, Lohavanichbutr P, Doody D, et al. Gene expression profiling identifies genes predictive of oral squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2008;17:2152-62.
http://dx.doi.org/10.1158/1055-9965.EPI-07-2893

 

31. Yang Y, Pospisil P, Iyer LK, Adelstein SJ, Kassis AI. Integrative genomic data mining for discovery of potential blood-borne biomarkers for early diagnosis of cancer. PloS one. 2008;3:e3661.
http://dx.doi.org/10.1371/journal.pone.0003661

 

32. Lucas N, Najy AJ, Day ML. The therapeutic potential of ADAM15. Current pharmaceutical design. 2009;15:2311-8.
http://dx.doi.org/10.2174/138161209788682370

 

33. Duffy MJ, McKiernan E, O'Donovan N, McGowan PM. Role of ADAMs in cancer formation and progression. Clin Cancer Res. 2009;15:1140-4.
http://dx.doi.org/10.1158/1078-0432.CCR-08-1585

 

34. Toquet C, Colson A, Jarry A, Bezieau S, Volteau C, Boisseau P, et al. ADAM15 to alpha5beta1 integrin switch in colon carcinoma cells: a late event in cancer progression associated with tumor dedifferentiation and poor prognosis. Int J Cancer. 2012;130:278-87.
http://dx.doi.org/10.1002/ijc.25891

 

35. Ungerer C, Doberstein K, Bürger C, Hardt K, Boehncke WH, Böhm B, et al. ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma. Biochem Biophys Res Commun. 2010;401:363-9.
http://dx.doi.org/10.1016/j.bbrc.2010.09.055

 

36. Montagnoli A, Moll J, Colotta F. Targeting cell division cycle 7 kinase: a new approach for cancer therapy. Clin Cancer Res. 2010;16:4503-8.
http://dx.doi.org/10.1158/1078-0432.CCR-10-0185

 

37. Kulkarni AA, Kingsbury SR, Tudzarova S, Hong HK, Loddo M, Rashid M, et al. Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma. Clin Cancer Res. 2009;15:2417-25.
http://dx.doi.org/10.1158/1078-0432.CCR-08-1276

 

38. Rodriguez-Acebes S, Proctor I, Loddo M, Wollenschlaeger A, Rashid M, Falzon M, et al. Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers. Am J Patho. 2010;177:2034-45.
http://dx.doi.org/10.2353/ajpath.2010.100421

 

39. Slebos RJ, Yi Y, Ely K, Carter J, Evjen A, Zhang X, et al. Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma. Clin Cancer Res. 2006;12:701-9.
http://dx.doi.org/10.1158/1078-0432.CCR-05-2017

 

40. Pistoia V, Cocco C, Airoldi I. Interleukin-12 receptor beta2: from cytokine receptor to gatekeeper gene in human B-cell malignancies. J Clin Oncol. 2009;27:4809-16.
http://dx.doi.org/10.1200/JCO.2008.21.3579

 

41. Tosolini M, Kirilovsky A, Mlecnik B, Fredriksen T, Mauger S, Bindea G, et al. Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer. Cancer Res. 2011;71:1263-71.
http://dx.doi.org/10.1158/0008-5472.CAN-10-2907

 

42. Airoldi I, Di Carlo E, Cocco C, Sorrentino C, Fais F, Cilli M, et al. Lack of Il12rb2 signaling predisposes to spontaneous autoimmunity and malignancy. Blood. 2005;106:3846-53.
http://dx.doi.org/10.1182/blood-2005-05-2034

 

43. Gasche JA, Hoffmann J, Boland CR, Goel A. Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells. Int J Cancer. 2011;129:1053-63.
http://dx.doi.org/10.1002/ijc.25764

 

44. Kang MR, Kang JS, Yang JW, Kim BG, Kim JA, Jo YN, et al. Gene expression profiling of KBH-A42, a novel histone deacetylase inhibitor, in human leukemia and bladder cancer cell lines. Oncol Lett. 2012;3:113-8.

 

45. Agnelli L, Mereu E, Pellegrino E, Limongi T, Kwee I, Bergaggio E, et al. (European T-Cell Lymphoma Study Group) Identification of a three-gene model as a powerful diagnostic tool for the recognition of ALK negative ALCL. Blood. 2012;120:1274-81.
http://dx.doi.org/10.1182/blood-2012-01-405555

 

46. Longoni M, Orzan F, Stroppi M, Boari N, Mortini P, Riva P. Evaluation of 1p36 markers and clinical outcome in a skull base chordoma study. Neuro Oncol. 2008;10:52-60.
http://dx.doi.org/10.1215/15228517-2007-048

 

47. Youden WJ. Index for rating diagnostic tests. Cancer. 1950;3:32-5.
http://dx.doi.org/10.1002/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3

 

48. Yin J, Tian L. Optimal linear combinations of multiple diagnostic biomarkers based on Youden index. Stat Med. 2014;33:1426-40.
http://dx.doi.org/10.1002/sim.6046