Chatzopoulos GS, Doufexi AE, Kalogirou F. Association of susceptible genotypes to periodontal disease with the clinical outcome and tooth survival after non-surgical periodontal therapy: A systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal. 2016 Jan 1;21 (1):e14-29. 

 

 

doi:10.4317/medoral.20638

http://dx.doi.org/doi:10.4317/medoral.20638

 

 

1. Lopez R, Baelum V. Classifying periodontitis among adolescents: implications for epidemiological research. Community Dent Oral Epidemiol. 2003;31:136-43.
http://dx.doi.org/10.1034/j.1600-0528.2003.00022.x

 

2. Page RC, Kornman KS. The pathogenesis of human periodontitis: an introduction. Periodontol 2000. 1997;14:9-11.
http://dx.doi.org/10.1111/j.1600-0757.1997.tb00189.x

 

3. Stabholz A, Soskolne WA, Shapira L. Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis. Periodontol 2000. 2010;53:138-53.
http://dx.doi.org/10.1111/j.1600-0757.2010.00340.x

 

4. Johnson NW, Griffiths GS, Wilton JM, Maiden MF, Curtis MA, Gillett IR, et al. Detection of high-risk groups and individuals for periodontal diseases. Evidence for the existence of high-risk groups and individuals and approaches to their detection. J Clin Periodontol. 1988;15:276-82.
http://dx.doi.org/10.1111/j.1600-051X.1988.tb01584.x

 

5. Loos BG, John RP, Laine ML. Identification of genetic risk factors for periodontitis and possible mechanisms of action. J Clin Periodontol. 2005;32(Suppl. 6):159-79.
http://dx.doi.org/10.1111/j.1600-051X.2005.00806.x

 

6. Hart TC. Genetic considerations of risk in human periodontal disease. Curr Opin Periodontol. 1994;3-11.

 

7. Michalowicz BS, Aeppli D, Virag JG, Klump DG, Hinrichs JE, Segal NL, et al. Periodontal findings in adult twins. J Periodontol. 1991;62:293-9.
http://dx.doi.org/10.1902/jop.1991.62.5.293

 

8. Sofaer JA. Genetic approaches in the study of periodontal diseases. J Clin Periodontol. 1990;17:401-8.
http://dx.doi.org/10.1111/j.1600-051X.1990.tb02337.x

 

9. Yoshie H, Kobayashi T, Tai H, Galicia JC. The role of genetic polymorphisms in periodontitis. Periodontol 2000. 2007;43:102-32.
http://dx.doi.org/10.1111/j.1600-0757.2006.00164.x

 

10. Kornman KS, Crane A, Wang HY, di Giovine FS, Newman MG, Pirk FW, et al. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol. 1997;24:72-7.
http://dx.doi.org/10.1111/j.1600-051X.1997.tb01187.x

 

11. McDevitt MJ, Wang HY, Knobelman C, Newman MG, di Giovine FS, Timms J, et al. Interleukin-1 genetic association with periodontitis in clinical practice. J Periodontol. 2000;71:156-63.
http://dx.doi.org/10.1902/jop.2000.71.2.156

 

12. Shapira L, van Dyke TE, Hart TC. A localized absence of interleukin-4 triggers periodontal disease activity: a novel hypothesis. Med Hypotheses. 1992;39:319-22.
http://dx.doi.org/10.1016/0306-9877(92)90056-I

 

13. Anovazzi G, Kim YJ, Viana AC, Curtis KM, Orrico SR, Cirelli JA, et al. Polymorphisms and haplotypes in the interleukin-4 gene are associated with chronic periodontitis in a Brazilian population. J Periodontol. 2010;81:392-402.
http://dx.doi.org/10.1902/jop.2009.090392

 

14. Leonard EJ, Yoshimura T. Neutrophil attractant/activation protein-1 (NAP-1 [interleukin-8]). Am J Respir Cell Mol Biol. 1990;2:479-86.
http://dx.doi.org/10.1165/ajrcmb/2.6.479

 

15. Scarel-Caminaga RM, Kim YJ, Viana AC, Curtis KM, Corbi SC, Sogumo PM, et al. Haplotypes in the interleukin 8 gene and their association with chronic periodontitis susceptibility. Biochem Genet. 2011;49:292-302.
http://dx.doi.org/10.1007/s10528-010-9407-3

 

16. Andia DC, de Oliveira NF, Letra AM, Nociti FH Jr, Line SR, de Souza AP. Interleukin-8 gene promoter polymorphism (rs4073) may contribute to chronic periodontitis. J Periodontol. 2011;82:893-9.
http://dx.doi.org/10.1902/jop.2010.100513

 

17. Sorsa T, TjŠderhane L, Salo T. Matrix metalloproteinases (MMPs) in oral diseases. Oral Dis. 2004;10:311-8.
http://dx.doi.org/10.1111/j.1601-0825.2004.01038.x

 

18. Parks WC. Matrix metalloproteinases in repair. Wound Repair Regen. 1999;7:423-32.
http://dx.doi.org/10.1046/j.1524-475X.1999.00423.x

 

19. Sapna G, Gokul S, Bagri-Manjrekar K. Matrix metalloproteinases and periodontal diseases. Oral Dis. 2014;20:538-50.
http://dx.doi.org/10.1111/odi.12159

 

20. Hou T, Gao L, Zheng J, Liu Z, Wu C, Liu Q, et al. Matrix metalloproteinase-1 gene polymorphisms and periodontitis susceptibility: a meta-analysis based on 11 case-control studies. Gene. 2013;521:111-5.
http://dx.doi.org/10.1016/j.gene.2013.02.014

 

21. Eisen DP, Minchinton RM. Impact of mannose-binding lectin on susceptibility to infectious diseases. Clin Infect Dis. 2003;37:1496-505.
http://dx.doi.org/10.1086/379324

 

22. Ozaka O, Biakci N, Nalbantsoy A, Kšse T, Berdeli A. Association between mannose-binding lectin levels and gene polymorphisms in chronic periodontitis and response to treatment. Arch Oral Biol. 2010;55:235-41.
http://dx.doi.org/10.1016/j.archoralbio.2009.12.006

 

23. Furlan AD, Pennick V, Bombardier C, van Tulder M. Editorial Board, Cochrane Back Review Group. 2009 updated method guidelines for systematic reviews in the Cochrane Back Review Group. Spine (Phila Pa 1976). 2009;34:1929-41.
http://dx.doi.org/10.1097/BRS.0b013e3181b1c99f

 

24. Moher D, Liberati A, Tetzlaff J, Altman DG. PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009;62:1006-12.
http://dx.doi.org/10.1016/j.jclinepi.2009.06.005

 

25. Li W, Ma D, Liu M, Liu H, Feng S, Hao Z, et al. Association between metabolic syndrome and risk of stroke: a meta-analysis of cohort studies. Cerebrovasc Dis. 2008;25:539-47.
http://dx.doi.org/10.1159/000131672

 

26. Chambrone L, Preshaw PM, Rosa EF, Heasman PA, Romito GA, Pannuti CM, et al. Effects of smoking cessation on the outcomes of non-surgical periodontal therapy: a systematic review and individual patient data meta-analysis. J Clin Periodontol. 2013;40:607-15.
http://dx.doi.org/10.1111/jcpe.12106

 

27. Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 2005;5:13.
http://dx.doi.org/10.1186/1471-2288-5-13

 

28. Lang NP, Tonetti MS, Suter J, Sorrell J, Duff GW, Kornman KS. Effect of interleukin-1 gene polymorphisms on gingival inflammation assessed by bleeding on probing in a periodontal maintenance population. J Periodontal Res. 2000;35:102-7.
http://dx.doi.org/10.1034/j.1600-0765.2000.035002102.x

 

29. Cattabriga M, Rotundo R, Muzzi L, Nieri M, Verrocchi G, Cairo F, et al. Retrospective evaluation of the influence of the interleukin-1 genotype on radiographic bone levels in treated periodontal patients over 10 years. J Periodontol. 2001;72:767-73.
http://dx.doi.org/10.1902/jop.2001.72.6.767

 

30. BŠumer A, El Sayed N, Kim TS, Reitmeir P, Eickholz P, Pretzl B. Patient-related risk factors for tooth loss in aggressive periodontitis after active periodontal therapy. J Clin Periodontol. 2011;38:347-54.
http://dx.doi.org/10.1111/j.1600-051X.2011.01698.x

 

31. Nieri M, Muzzi L, Cattabriga M, Rotundo R, Cairo F, Pini Prato GP. The prognostic value of several periodontal factors measured as radiographic bone level variation: a 10-year retrospective multilevel analysis of treated and maintained periodontal patients. J Periodontol. 2002;73:1485-93.
http://dx.doi.org/10.1902/jop.2002.73.12.1485

 

32. Persson GR, MatulienŽ G, Ramseier CA, Persson RE, Tonetti MS, Lang NP. Influence of interleukin-1 gene polymorphism on the outcome of supportive periodontal therapy explored by a multi-factorial periodontal risk assessment model (PRA). Oral Health Prev Dent. 2003;1:17-27.

 

33. Kšnig J, RŸhling A, Plagmann HC, Meisel P, Kocher T. Influence of interleukin (IL)-1 composite genotype on clinical variables in non-smoking, well-maintained compliant patients with chronic periodontitis. Swed Dent J. 2005;29:11-6.

 

34. Muzzi L, Nieri M, Cattabriga M, Rotundo R, Cairo F, Pini Prato GP. The potential prognostic value of some periodontal factors for tooth loss: a retrospective multilevel analysis on periodontal patients treated and maintained over 10 years. J Periodontol. 2006;77:2084-9.
http://dx.doi.org/10.1902/jop.2006.050227

 

35. Wolf DL, Neiderud AM, Hinckley K, DahlŽn G, van de Winkel JG, Papapanou PN. Fcgamma receptor polymorphisms and periodontal status: a prospective follow-up study. J Clin Periodontol. 2006;33:691-8.
http://dx.doi.org/10.1111/j.1600-051X.2006.00973.x

 

36. Eickholz P, Kaltschmitt J, Berbig J, Reitmeir P, Pretzl B. Tooth loss after active periodontal therapy. 1: patient-related factors for risk, prognosis, and quality of outcome. J Clin Periodontol. 2008;35:165-74.
http://dx.doi.org/10.1111/j.1600-051X.2007.01184.x

 

37. Nibali L, Pelekos G, D'Aiuto F, Chaudhary N, Habeeb R, Ready D, et al. Influence of IL-6 haplotypes on clinical and inflammatory response in aggressive periodontitis. Clin Oral Investig. 2013;17:1235-42.

 

38. Ehmke B, Kress W, Karch H, Grimm T, Klaiber B, Flemmig TF. Interleukin-1 haplotype and periodontal disease progression following therapy. J Clin Periodontol. 1999;26:810-3.
http://dx.doi.org/10.1111/j.1600-051X.1999.tb02525.x

 

39. Jeffcoat MK, Jeffcoat RL, Tanna N, Parry SH. Association of a common genetic factor, PTGER3, with outcome of periodontal therapy and preterm birth. J Periodontol. 2014;85:446-54.
http://dx.doi.org/10.1902/jop.2013.130006

 

40. Emingil G, Han B, GŸrkan A, Berdeli A, Tervahartiala T, Salo T, et al. Matrix metalloproteinase (MMP)-8 and tissue inhibitor of MMP-1 (TIMP-1) gene polymorphisms in generalized aggressive periodontitis: gingival crevicular fluid MMP-8 and TIMP-1 levels and outcome of periodontal therapy. J Periodontol. 2014;85:1070-80.
http://dx.doi.org/10.1902/jop.2013.130365

 

41. Anovazzi G, Finoti LS, Corbi SC, Kim YJ, Marcaccini AM, Gerlach RF, et al. Interleukin 4 haplotypes of susceptibility to chronic periodontitis are associated with IL-4 protein levels but not with clinical outcomes of periodontal therapy. Hum Immunol. 2013;74:1688-95.
http://dx.doi.org/10.1016/j.humimm.2013.08.286

 

42. Finoti LS, Anovazzi G, Pigossi SC, Corbi SC, Teixeira SR, Braido GV, et al. Periodontopathogens levels and clinical response to periodontal therapy in individuals with the interleukin-4 haplotype associated with susceptibility to chronic periodontitis. Eur J Clin Microbiol Infect Dis. 2013;32:1501-9.
http://dx.doi.org/10.1007/s10096-013-1903-z

 

43. Finoti LS, Corbi SC, Anovazzi G, Teixeira SR, Capela MV, Tanaka MH, et al. Pathogen levels and clinical response to periodontal treatment in patients with Interleukin 8 haplotypes. Pathog Dis. 2013 Jul 2 [Epub ahead of print].
http://dx.doi.org/10.1111/2049-632X.12062

 

44. Pirhan D, Atilla G, Emingil G, Sorsa T, Tervahartiala T, Berdeli A. Effect of MMP-1 promoter polymorphisms on GCF MMP-1 levels and outcome of periodontal therapy in patients with severe chronic periodontitis. J Clin Periodontol. 2008;35:862-70.
http://dx.doi.org/10.1111/j.1600-051X.2008.01302.x

 

45. Pirhan D, Atilla G, Emingil G, Tervahartiala T, Sorsa T, Berdeli A. MMP-13 promoter polymorphisms in patients with chronic periodontitis: effects on GCF MMP-13 levels and outcome of periodontal therapy. J Clin Periodontol. 2009;36:474-81.
http://dx.doi.org/10.1111/j.1600-051X.2009.01399.x

 

46. Corbi SC, Finoti LS, Anovazzi G, Tanaka MH, Kim YJ, Secolin R, et al. Clinical outcomes of periodontal therapy are not influenced by the ATC/TTC haplotype in the IL8 gene. J Periodontol Res. 2014;49:489-98.
http://dx.doi.org/10.1111/jre.12128

 

47. D'Aiuto F, Ready D, Parkar M, Tonetti MS. Relative contribution of patient-, tooth-, and site-associated variability on the clinical outcomes of subgingival debridement. I. Probing depths. J Periodontol. 2005;76:398-405.
http://dx.doi.org/10.1902/jop.2005.76.3.398

 

48. Yoshie H, Tai H, Kobayashi T, Oda-Gou E, Nomura Y, Numabe Y, et al. Salivary enzyme levels after scaling and interleukin-1 genotypes in Japanese patients with chronic periodontitis. J Periodontol. 2007;78:498-503.
http://dx.doi.org/10.1902/jop.2007.060216

 

49. McGuire MK, Nunn ME. Prognosis versus actual outcome. IV. The effectiveness of clinical parameters and IL-1 genotype in accurately predicting prognoses and tooth survival. J Periodontol. 1999;70:49-56.
http://dx.doi.org/10.1902/jop.1999.70.1.49

 

50. Huynh-Ba G, Lang NP, Tonetti MS, Salvi GE. The association of the composite IL-1 genotype with periodontitis progression and/or treatment outcomes: a systematic review. J Clin Periodontol. 2007;34:305-17.
http://dx.doi.org/10.1111/j.1600-051X.2007.01055.x

 

51. Hull J, Thomson A, Kwiatkowski D. Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. Thorax. 2000;55:1023-7.
http://dx.doi.org/10.1136/thorax.55.12.1023

 

52. Sumiya M, Super M, Tabona P, Levinsky RJ, Arai T, Turner MW, et al. Molecular basis of opsonic defect in immunodeficient children. Lancet. 1991;337:1569-70.
http://dx.doi.org/10.1016/0140-6736(91)93263-9

 

53. Wallis R, Cheng JY. Molecular defects in variant forms of mannose-binding protein associated with immunodeficiency. J Immunol. 1999;163:4953-9.

 

54. Lyons JG, Birkedal-Hansen B, Moore WG, O'Grady RL, Birkedal-Hansen H. Characteristics of a 95-kDa matrix metalloproteinase produced by mammary carcinoma cells. Biochemistry. 1991;30:1449-56.
http://dx.doi.org/10.1021/bi00220a001

 

55. DeClerck YA, Yean TD, Lu HS, Ting J, Langley KE. Inhibition of autoproteolytic activation of interstitial procollagenase by recombinant metalloproteinase inhibitor MI/TIMP-2. J Biol Chem. 1991;266:3893-9.

 

56. Howard EW, Bullen EC, Banda MJ. Regulation of the autoactivation of human 72-kDa progelatinase by tissue inhibitor of metalloproteinases-2. J Biol Chem. 1991;266:13064-9.

 

57. Rutter JL, Mitchell TI, Buttic G, Meyers J, Gusella JF, Ozelius LJ, et al. A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription. Cancer Res. 1998;58:5321-5.

 

58. Nakashima H, Miyake K, Inoue Y, Shimizu S, Akahoshi M, Tanaka Y, et al. Association between IL-4 genotype and IL-4 production in the Japanese population. Genes Immun. 2002;3:107-9.
http://dx.doi.org/10.1038/sj.gene.6363830

 

59. Shirodaria S, Smith J, McKay IJ, Kennett CN, Hughes FJ. Polymorphisms in the IL-1A gene are correlated with levels of interleukin-1alpha protein in gingival crevicular fluid of teeth with severe periodontal disease. J Dent Res. 2000;79:1864-9.
http://dx.doi.org/10.1177/00220345000790110801

 

60. Armitage GC, Wu Y, Wang HY, Sorrell J, Giovine FS, Duff GW. Low prevalence of a periodontitis-associated interleukin-1 composite genotype in individuals of Chinese herritage. J Periodontol. 2000;71:164-71.
http://dx.doi.org/10.1902/jop.2000.71.2.164

 

61. Br’gido JA, da Silveira VR, Rego RO, Nogueira NA. Serotypes of Aggregatibacter actinomycetemcomitans in relation to periodontal status and geographic origin of individuals-a review of the literature. Med Oral Patol Oral Cir Bucal. 2014;19:e184-91.
http://dx.doi.org/10.4317/medoral.19304

 

62. Hart TC, Ferrell RE. Genetic testing considerations for oral medicine. J Dent Educ. 2002;66:1185-202.

 

63. Garcia I, Tabak LA. A view of the future: dentistry and oral health in America. J Am Dent Assoc. 2009;140 (Suppl 1):44S-8S.
http://dx.doi.org/10.14219/jada.archive.2009.0357

 

64. Hayden JA, van der Windt DA, Cartwright JL, C™tŽ P, Bombardier C. Assessing bias in studies of prognostic factors. Ann Intern Med. 2013;158:280-6.
http://dx.doi.org/10.7326/0003-4819-158-4-201302190-00009