Martins LD, Rezende M, Loguercio AD, Bortoluzzi MC, Reis A. Analgesic efficacy of ketorolac associated with a tramadol/acetaminophen combination after third molar surgery - a randomized, triple-blind clinical trial. Med Oral Patol Oral Cir Bucal. 2019 Jan 1;24 (1):e96-102. 

 

 

doi:10.4317/medoral.22744

http://dx.doi.org/doi:10.4317/medoral.22744

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1. Haraji, A. and V. Rakhshan. Chlorhexidine gel and less difficult surgeries might reduce post-operative pain, controlling for dry socket, infection and analgesic consumption: a split-mouth controlled randomised clinical trial. J Oral Rehabil. 2015;42:209-19.
https://doi.org/10.1111/joor.12230
PMid:25251411

 

2. Osunde OD, Adebola RA, Omeje UK.Management of inflammatory complications in third molar surgery: a review of the literature. Afr Health Sci. 2011;11:530-7.
PMid:22275950 PMCid:PMC3261018

 

3. López Carriches C, Martínez González JM, Donado Rodríguez M. The use of methylprednisolone versus diclofenac in the treatment of inflammation and trismus after surgical removal of lower third molars. Med Oral Patol Oral Cir Bucal. 2006;11:E440-5.
PMid:16878063

 

4. Ong CK, Seymour RA.Pathogenesis of postoperative oral surgical pain. Anesth Prog. 2003;50:5-17.
PMid:12722900 PMCid:PMC2007420

 

5. Vegas-Bustamante E, Mico-Llorens J, Gargallo-Albiol J, Satorres-Nieto M, Berini-Aytes L, Gay-Escoda C.Efficacy of methylprednisolone injected into the masseter muscle following the surgical extraction of impacted lower third molars. Int J Oral Maxillofac Surg. 2008;37:260-3.
https://doi.org/10.1016/j.ijom.2007.07.018
PMid:18296027

 

6. Forbes JA, Kehm CJ, Grodin CD, Beaver WT. Evaluation of ketorolac, ibuprofen, acetaminophen, and an acetaminophen-codeine combination in postoperative oral surgery pain. Pharmacotherapy. 1990;10:94S-105S.
PMid:2082318

 

7. McAleer SD, Majid O, Venables E, Polack T, Sheikh MS. Pharmacokinetics and safety of ketorolac following single intranasal and intramuscular administration in healthy volunteers. J Clin Pharmacol 2007;47:13-8.
https://doi.org/10.1177/0091270006294597
PMid:17192497

 

8. Flores-Murrieta FJ, Granados-Soto V. Pharmacologic Properties of Ketorolac Tromethamine: A Potent Analgesic Drug. CNS Drug Reviews. 1996;2:75-90.
https://doi.org/10.1111/j.1527-3458.1996.tb00291.x

 

9. Mehlisch DR, Desjardins PJ, Daniels S, Hubbard RC. Single doses of parecoxib sodium intravenously are as effective as ketorolac in reducing pain after oral surgery. J Oral Maxillofac Surg. 2003;61:1030-7.
https://doi.org/10.1016/S0278-2391(03)00315-X

 

10. Trindade PA, Giglio FP, Colombini-Ishikiriama BL, A Calvo AM, Modena KC, Ribeiro DA, et al. Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:27-34.
https://doi.org/10.1016/j.tripleo.2011.05.027
PMid:22732846

 

11. Raffa RB. Pharmacology of oral combination analgesics: rational therapy for pain. J Clin Pharm Ther. 2001;26:257-64.
https://doi.org/10.1046/j.1365-2710.2001.00355.x
PMid:11493367

 

12. Au AH, Choi SW, Cheung CW, Leung YY. The Efficacy and Clinical Safety of Various Analgesic Combinations for Post-Operative Pain after Third Molar Surgery: A Systematic Review and Meta-Analysis. PLoS One. 2005;10:e0127611.
https://doi.org/10.1371/journal.pone.0127611
PMid:26053953 PMCid:PMC4459961

 

13. Jung YS, Kim DK, Kim MK, Kim HJ, Cha IH, Lee EW. Onset of analgesia and analgesic efficacy of tramadol/acetaminophen and codeine/acetaminophen/ibuprofen in acute postoperative pain: a single-center, single-dose, randomized, active-controlled, parallel-group study in a dental surgery pain model. Clin Ther. 2004;26:1037-45.
https://doi.org/10.1016/S0149-2918(04)90175-0

 

14. Schulz KF, Altman DG, Moher D; CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. Int J Surg. 2011;9:672-7.
https://doi.org/10.1016/j.ijsu.2011.09.004
PMid:22019563

 

15. Ong KS, Tan JM. Preoperative intravenous tramadol versus ketorolac for preventing postoperative pain after third molar surgery. Int J Oral Maxillofac Surg. 2004;33:274-8.
https://doi.org/10.1006/ijom.2003.0515
PMid:15287311

 

16. Isiordia-Espinoza MA, Pozos-Guillen A, Martinez-Rider R, Perez-Urizar J. Comparison of the analgesic efficacy of oral ketorolac versus intramuscular tramadol after third molar surgery: A parallel, double-blind, randomized, placebo-controlled clinical trial. Med Oral Patol Oral Cir Bucal. 2016;21:e637-43.
https://doi.org/10.4317/medoral.21077

 

17. Ong KS, Seymour RA, Chen FG, Ho VC. Preoperative ketorolac has a preemptive effect for postoperative third molar surgical pain. Int J Oral Maxillofac Surg. 2004;33:771-6.
https://doi.org/10.1006/ijom.2003.0515
https://doi.org/10.1016/j.ijom.2004.01.020
PMid:15556325

 

18. Ong CK, Seymour RA. An evidence-based update of the use of analgesics in dentistry. Periodontol 2000. 2008;46:143-64.
https://doi.org/10.1111/j.1600-0757.2008.00225.x
PMid:18201349

 

19. Paiva-Oliveira JG, Bastos PR, Cury Pontes ER, da Silva JC, Delgado JA, Oshiro-Filho NT.Comparison of the anti-inflammatory effect of dexamethasone and ketorolac in the extractions of third molars. Oral Maxillofac Surg. 2016;20:123-33.
https://doi.org/10.1007/s10006-015-0533-2
PMid:26572899

 

20. Colombini BL, Modena KC, Calvo AM, Sakai VT, Giglio FP, Dionisio TJ, et al. Articaine and mepivacaine efficacy in postoperative analgesia for lower third molar removal: a double-blind, randomized, crossover study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:169-74.
https://doi.org/10.1016/j.tripleo.2005.09.003
PMid:16876058

 

21. Tuzuner Oncul AM, Yazicioglu D, Alanoglu Z, Demiralp S, Ozturk A, Ucok C. Postoperative analgesia in impacted third molar surgery: the role of preoperative diclofenac sodium, paracetamol and lornoxicam. Med Princ Pract. 2011;20:470-6.
https://doi.org/10.1159/000327658
PMid:21757939

 

22. Tallarida RJ. Drug synergism: its detection and applications. J Pharmacol Exp Ther. 2001;298:865-72.
PMid:11504778

 

23. Ortiz MI, Molina MA, Arai YC, Romano CL. Analgesic drugs combinations in the treatment of different types of pain. Pain Res Treat. 2012;2012:612519.
https://doi.org/10.1155/2012/612519

 

24. Galan-Herrera JF, Poo JL, Maya-Barrios JA, de Lago A, Oliva I, Gonzalez-de la Parra M, et al. Bioavailability of two sublingual formulations of ketorolac tromethamine 30 mg: a randomized, open-label, single-dose, two-period crossover comparison in healthy Mexican adult volunteers. Clin Ther. 2008;30:1667-74.
https://doi.org/10.1016/j.clinthera.2008.09.011
PMid:18840372

 

25. Rooks WH 2nd. The pharmacologic activity of ketorolac tromethamine. Pharmacotherapy. 1990;10:30S-32S.
PMid:2082310

 

26. Miranda HF, Puig MM, Prieto JC, Pinardi G. Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain. Pain. 2006;121:22-8.
https://doi.org/10.1016/j.pain.2005.11.012
PMid:16480830

 

27. Lopez-Munoz FJ, Diaz-Reval MI, Terron JA, Deciga-Campos M. Analysis of the analgesic interactions between ketorolac and tramadol during arthritic nociception in rat. Eur J Pharmacol. 2004;484:157-65.
https://doi.org/10.1016/j.ejphar.2003.11.005
PMid:14744599

 

28. Mishra H, Khan FA. A double-blind, placebo-controlled randomized comparison of pre and postoperative administration of ketorolac and tramadol for dental extraction pain. J Anaesthesiol Clin Pharmacol. 2012;28:221-5.
https://doi.org/10.4103/0970-9185.94892
PMid:22557747 PMCid:PMC3339729

 

29. da Costa Araujo FA, de Santana Santos T, de Morais HH, Laureano Filho JR, de Oliveira ESED, Vasconcellos RJ. Comparative analysis of preemptive analgesic effect of tramadol chlorhydrate and nimesulide following third molar surgery. J Craniomaxillofac Surg. 2012;40:e346-9.
https://doi.org/10.1016/j.jcms.2012.01.018
PMid:22421470