López-Verdín S, Martínez-Fierro ML, Garza-Veloz I, Zamora-Perez A, Grajeda-Cruz J, González-González R, Molina-Frechero N, Arocena- Sutz M, Bologna-Molina R. E-Cadherin gene expression in oral cancer: Clinical and prospective data. Med Oral Patol Oral Cir Bucal. 2019 Jul 1;24 (4):e444-51.   

 

doi:10.4317/medoral.23029

http://dx.doi.org/doi:10.4317/medoral.23029

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References

1. Bray F. Transitions in human development and the global cancer burden. In: Wild CP, Stewart B (ed). World cancer report 2014. Lyon: International Agency for Research on Cancer. 2014;23-44.
https://doi.org/10.1596/978-1-4648-0349-9_ch2
PMid:26913347

 

2.Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2012;136:E359-E386.
https://doi.org/10.1002/ijc.29210
PMid:25220842

 

3. Fernandes A, Pinto F, Shien L, Vamondes M, Cernea C. Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis. Brazilian Journal of Otorhinolaryngology. 2015;130:1-7.

 

4.Brennan M, Migliorati CA, Lockhart PB, Wray D, Al-Hashimi I, Axéll T, Bruce AJ, et al. Management of oral epithelial displasia: a review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:e1-e12.
https://doi.org/10.1016/j.tripleo.2006.10.015
PMid:17257863

 

5. Massano J, Regateiro FS, Januario G, Ferreira A. Oral squamous cell carcinoma: review of prognostic and predictive factors. Oral Surg Oral Med Oral Patho Oral Radiol Endod. 2006;103:67-76.
https://doi.org/10.1016/j.tripleo.2005.07.038
PMid:16831675

 

6. Berx G, van Roy F. Involvement of Members of the Cadherin Superfamily in Cancer. Cold Spring HarbPerspectBiol. 2009;1:a0031.
https://doi.org/10.1101/cshperspect.a003129
PMid:20457567 PMCid:PMC2882122

 

7. Lau MT, Klausen C and Leung PCK. E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression. Oncogene. 2011;30:2753-2766.
https://doi.org/10.1038/onc.2011.6
PMid:21297666

 

8. Barrallo-Gimeno A, Nieto MA. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development. 2005;132:3151-3161.
https://doi.org/10.1242/dev.01907
PMid:15983400

 

9.Caberg JH, Hubert PM, Begon DY, Herfs MF, Roncarati PJ, et al. Silencing of E7 oncogene restores functional E-cadherin expression in human papillomavirus 16-transformed keratinocytes. Carcinogenesis. 2008;29:1441-1447.
https://doi.org/10.1093/carcin/bgn145
PMid:18566017

 

10. Cobaleda C, Perez-Caro M, Vicente-Dueñas C, Sánchez-García I. Function of the zinc-finger transcription factor SNAI2 in cáncer and development. Annu Rev Genet. 2007;41:41-61.
https://doi.org/10.1146/annurev.genet.41.110306.130146
PMid:17550342

 

11.Mattijssen V, Peters H, Schalkwijk L, Manni JJ, vant't Hof-Grootenboer B, de Mulder PH, et al. E-cadherin expression in head and neck quamous cell carcinomas is associated with clinical outcome. International Journal of Cancer. 1993;55:580-585.
https://doi.org/10.1002/ijc.2910550411
PMid:8406985

 

12. Diniz-Freitas Márcio, García-Caballero Tomás, Antúnez-López José, Gándara-Rey José Manuel, García-García Abel. Reduced E-cadherin expresión is an indicator of unfavourable prognosis in oral squamous cell carcinoma. Oral Oncology. 2006;42:190-200.
https://doi.org/10.1016/j.oraloncology.2005.07.010
PMid:16249116

 

13. Zhao Z, Ge J, Sun Y, Tian L, Lu J, Liu M and Zhao Y. Is E-cadherina inmunoexpression a prognostic factor for head and neck squamous cell carcinoma (HNSCC)? A systematic review and meta-analysis. Oral Oncology. 2012;48:761-767.
https://doi.org/10.1016/j.oraloncology.2012.02.024
PMid:22455948

 

14. Jia-Yo W, Chen Y, Ho-Ren C, Duen-Jeng W, Wen-Chien C, Sheng-Yang L, et al. Potential biomarkers in saliva for oral squamous cell carcinoma. Oral Oncology. 2010;46:226-231.
https://doi.org/10.1016/j.oraloncology.2010.01.007
PMid:20138569

 

15. Yuwanati MB, Tupkari JV, Avadhani A. Expression of E-cadherin in oral epithelial dysplasia and oral squamous cell carcinoma: An in vivo study. Journal of Clinical and Experimental Investigations. 2011;2:347-353.
https://doi.org/10.5799/ahinjs.01.2011.04.0070

 

16. Andrews NA, Jones AS, Helliwell TR and Kinsella AR. Expression of the E-cadherin-catenin cell adhesion complex in primary squamous cell carcinomas of the head and neck and their nodal metastases. Britishh Journal of Cancer. 1997;75:1474-1480.
https://doi.org/10.1038/bjc.1997.252
PMid:9166940

 

17.Tanaka N, Odajma T, Ogi K, Ikeda T, and Satoh M. Expression of E-cadherin, α-catenin and β-catenin in the process of lymph node metastasis in oral squamous cell carcinoma. British Journal of Cancer. 2003;89:557-563.
https://doi.org/10.1038/sj.bjc.6601124
PMid:12888830 PMCid:PMC2394393

 

18.Wang X, Zhang J, Mingwen F, Zhou Q, Deng H, Aisharif MJ, et al. The expression of E-cadherin at the invasive tumor front of oral suqamous cell carcinoma: inmunohistochemical and RT-PCR analysis with clinicopathological correlation. Oral Surg Oral Med Oral Path Oral RadiolEndod. 2009;107:547-554.
https://doi.org/10.1016/j.tripleo.2008.11.021
PMid:19327640

 

19. Rosado P, Leuqerica-Fernández P, Fernández S, Allonca E, Villallaín L, de Vicente JC. E-cadherin and β-catenin expression in well-differentiated and moderately differentiated oral squamous cell carcinoma: relation with clinical variables. Br J Oral MaxillofacialSurg. 2013;51:149-56.
https://doi.org/10.1016/j.bjoms.2012.03.018
PMid:22525043

 

20.Sasaya K, Sudo H, Maeda G, Kawashiri S and Imai K. Concomitant Loss of p120-Catenina and β-catenin Membrane Expression and Oral Carcinoma Progression with E-cadherin Reduction. PLOS ONE. 2013;8:e69777.
https://doi.org/10.1371/journal.pone.0069777
PMid:23936352 PMCid:PMC3735538

 

21.Pectasides E, Rampias T, Sasaki C, Perisanidis C, Kouloulias V, Burtness B, et al. Markers of Epithelial to Mesenchymal Transition in Association with Survival in Head and Neck Squamous Cell Carcinoma (HNSCC). PLOS One. 2014;9:e94273.
https://doi.org/10.1371/journal.pone.0094273
PMid:24722213 PMCid:PMC3983114

 

22. Jiang Y, Liao L, Shrestha C, Ji S, Chen Y, Peng J, et al. Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC- γ1 and PIKE are associated with aggressiveness of oral squamoous cell carcinoma. Int J Clin Exp Pathol. 2015;8:9042-9051.

 

23. Yao X, Sun S, Zhou X, Zhang Q, Guo W, Zhang L. Clinicopathological significance of ZEB-I and E-cadherin proteins in patients qith oral cavity squamous cell carcinoma. OncoTargets and Therapy. 2017;10:781-790.
https://doi.org/10.2147/OTT.S111920
PMid:28243114 PMCid:PMC5315354

 

24. Meyerson M, Gabriel S, Gets G. (Advances in understanding cáncer genomes through second-generation sequencing. Nature Reviews Genetics. 2010;11:685-96.
https://doi.org/10.1038/nrg2841
PMid:20847746

 

25. AJCC: Lip and Oral cavity. En: Edge SB, Byrd DR, Compton CC, et al., 7th eds. En: AJCC Cancer Staging Manual. 8th ed. New York, NY: Springer, 2010, pp 29-40
https://doi.org/10.1007/978-0-387-88441-7_3

 

26. National Cancer Institute available in https://www.nih.gov/about-nih/what-we-do/nih-almanac/national-cancer-institute-nci accessed August 19, 2016.

 

27. DeSouza M, Weslley P, Calsolari M. Persistent and recurrent disease in ptient with papillary thyroid carcinoma with clinically apparent (cN1), but no extensive, lymph node involvement and without other factors for por prognosis Arch Endocrinol Metab. 2015;59:285-291.
https://doi.org/10.1590/2359-3997000000081
PMid:26331314

 

28. Greene F, Page D, Fleming I, et al., AJCC Cancer Staging Hadbook Colon and rectum. New York: Springer. 2003 pp127-138

 

29. Hanahan D, Weinberg R. Hallmarks of cancer. The next generation. Cell. 2011;144:646-674.
https://doi.org/10.1016/j.cell.2011.02.013
PMid:21376230

 

30. Olmeda D, Montes A, Moreno-Bueno G, Flores JM, Portillo F, et al. Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines. Oncogene 2008;27:4690-4701.
https://doi.org/10.1038/onc.2008.118
PMid:18408755

 

31. Sobral LM, Sousa LO, Coletta RD, Cabral H, Greene LJ, Tajara EH, et al. Stable SET knockdown in head and neck squemous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. Molecular Cancer. 2014;13:32.
https://doi.org/10.1186/1476-4598-13-32
PMid:24555657 PMCid:PMC3936887

 

32.Tamagawa S, Beder LB, Hotomi M, Gunduz M, Yata K, Grenmar R, et al. Role of miR-200c/miR-141 in the regulation of epithelial-mesenchymal transition and migration in head and neck squamous cell carcinoma. Int J MoL Med. 2014;33:879-86.
https://doi.org/10.3892/ijmm.2014.1625
PMid:24424572

 

33. Carver EA, Jiang R, Lan Y, Oram KF, Gridley T. The mouse snail gene encodes a key regulator of the epithelial mesenchymal transition. Mol Cell Biol. 2001;21:8184-8.
https://doi.org/10.1128/MCB.21.23.8184-8188.2001
PMid:11689706 PMCid:PMC99982

 

34. Subbaiah VK, Kranjec C, Thomas M, Banks L. PDZ domains: the building blocks regulating tumorigenesis. Biochem J. 2011;439:195-205.
https://doi.org/10.1042/BJ20110903
PMid:21954943

 

35. D'Costa ZJ, Leong CM, Shields J, Matthews C, Hibma MH. Screening of drugs to counteract human papillomavirus 16 E6 repression of E-cadherinexpression. Invest New Drugs. PLOS one. 2012;7:e48954.
https://doi.org/10.1371/journal.pone.0048954
PMid:23189137 PMCid:PMC3506579

 

36. Al Moustafa AE, D Foulkes W, Benliname N, Wong A, Yen L, Bergeron J, et al. E6/E7 proteins of HPV type 16 and ErbB-2 cooperate to induce neoplastic transformation of primary normal oral epithelial cells. Oncogene. 2004;23:350-8.
https://doi.org/10.1038/sj.onc.1207148
PMid:14724563

 

37. Wang C, Liu X, Chen Z, Huang H, Jin Y, Kolokythas A, et al. Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma. MolCarcinog. 2013;52:229-236.
https://doi.org/10.1002/mc.21848
PMid:22161744 PMCid:PMC3400713