Ustrell-Borràs M, Traboulsi-Garet B, Gay-Escoda C. Alcohol-based mouthwash as a risk factor of oral cancer: A systematic review. Med Oral Patol Oral Cir Bucal. 2020 Jan 1;25 (1):e1-12.

doi:10.4317/medoral.23085

http://dx.doi.org/doi:10.4317/medoral.23085


1. Winn DM, Diehl SR, Brown LM, Harty LC, Bravo-Otero E, Fraumeni JFJ, et al. Mouthwash in the etiology of oral cancer in Puerto Rico. Cancer Causes Control. 2001;12:419-29.
https://doi.org/10.1023/A:1011291807468
PMid:11545457

 

2. Blot WJ, Winn DM, Fraumeni JFJ. Oral cancer and mouthwash. J Natl Cancer Inst. 1983;70:251-3.

 

3. Zheng TZ, Boyle P, Hu HF, Duan J, Jian PJ, Ma DQ, et al. Dentition, oral hygiene, and risk of oral cancer: A case-control study in Beijing, People's Republic of China. Cancer Causes Control. 1990;1:235-41.
https://doi.org/10.1007/BF00053170
https://doi.org/10.1007/BF00117475
PMid:2102296

 

4. Kreimer AR, Clifford GM, Boyle P, Franceschi S. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: A systematic review. Cancer Epidemiol Biomarkers Prev. 2005;14:467-75.
https://doi.org/10.1158/1055-9965.EPI-04-0551
PMid:15734974

 

5. Gandini S, Negri E, Boffetta P, La Vecchia C, Boyle P. Mouthwash and oral cancer risk quantitative meta-analysis of epidemiologic studies. Ann Agric Environ Med. 2012;19:173-80.

 

6. Homann N, Tillonen J, Meurman JH, Rintamäki H, Lindqvist C, Rautio M, et al. Increased salivary acetaldehyde levels in heavy drinkers and smokers: A microbiological approach to oral cavity cancer. Carcinogenesis. 2000;21:663-8.
https://doi.org/10.1093/carcin/21.4.663
PMid:10753201

 

7. Homann N, Tillonen J, Rintamäki H, Salaspuro M, Lindqvist C, Meurman JH. Poor dental status increases acetaldehyde production from ethanol in saliva: A possible link to increased oral cancer risk among heavy drinkers. Oral Oncol. 2001;37:153-8.
https://doi.org/10.1016/S1368-8375(00)00076-2

 

8. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Int J Surg. 2010;8:336-41.
https://doi.org/10.1016/j.ijsu.2010.02.007
PMid:20171303

 

9. Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analysis. Ottawa Hosp Res Inst. 2013;3:1-4.

 

10. Burns PB, Rohrich RJ, Chung KC. The levels of evidence and their role in evidence-based medicine. Plast Reconstr Surg. 2011;128:305-10.
https://doi.org/10.1097/PRS.0b013e318219c171
PMid:21701348 PMCid:PMC3124652

 

11. Lemos CA Jr, Villoria GE. Reviewed evidence about the safety of the daily use of alcohol-based mouthrinses. Braz Oral Res. 2008;1:24-31.
https://doi.org/10.1590/S1806-83242008000500005
PMid:19838548

 

12. Carretero-Pelaez MA, Esparza-Gomez GC, Figuero-Ruiz E, Cerero-Lapiedra R. Alcohol-containing mouthwashes and oral cancer. Critical analysis of literature. Med Oral. 2004;9:116-23.

 

13. Cole P, Rodu B, Mathisen A. Alcohol-containing mouthwash and oropharyngeal cancer: A review of the epidemiology. J Am Dent Assoc. 2003;134:1079-87.
https://doi.org/10.14219/jada.archive.2003.0322
PMid:12956348

 

14. Reidy JT, McHugh EE, Stassen LF. A review of the role of alcohol in the pathogenesis of oral cancer and the link between alcohol-containing mouthrinses and oral cancer. J Ir Dent Assoc. 2011;57:200-2.

 

15. Wilson G, Conway DI. Mouthwash use and associated head and neck cancer risk. Evid Based Dent. 2016;17:8-9.
https://doi.org/10.1038/sj.ebd.6401146
PMid:27012566

 

16. Blanc SAL, Baruzzi AM. Mouthrinses containing alcohol and oral cancer: Revision of epidemiological studies. Braz Oral Res. 2007;21:16-22.
https://doi.org/10.1590/S1806-83242007000500004

 

17. McCullough MJ, Farah CS. The role of alcohol in oral carcinogenesis with particular reference to alcohol-containing mouthwashes. Aust Dent J. 2008;53:302-5.
https://doi.org/10.1111/j.1834-7819.2008.00070.x
PMid:19133944

 

18. La-Vecchia C. Mouthwash and oral cancer risk: An update. Oral Oncol. 2009;45:198-200.
https://doi.org/10.1016/j.oraloncology.2008.08.012
PMid:18952488

 

19. Werner CW, Seymour RA, Speight P. Are alcohol containing mouthwashes safe?. Br Dent J. 2009;19:488-9.
https://doi.org/10.1038/sj.bdj.2009.1014
PMid:19942865

 

20. Speight P. Summary of: Are alcohol containing mouthwashes safe?. Br Dent J. 2009;207:488-9.
https://doi.org/10.1038/sj.bdj.2009.1039

 

21. Ciancio SG. Alcohol-containing mouthwashes. Aus Dent J. 2009;54:173-9.
https://doi.org/10.1111/j.1834-7819.2009.01116_3.x
PMid:19473166

 

22. Lachenmeier DW. Alcohol-containing mouthwash and oral cancer - Can epidemiology prove the absence of risk?. Ann Agric Environ Med. 2012;19:609-10.

 

23. Biron CR. Is alcohol that dangerous in dentistry?. RDH. 1999;19:16-8.

 

24. Walsh LJ. The mouthwash question. Aus Dent J. 2009;54:77-81.
https://doi.org/10.1111/j.1834-7819.2008.01097_1.x
PMid:19228141

 

25. Balbo S, Meng L, Bliss RL, Jensen JA, Hatsukami DK, Hecht S. Kinetics of DNA adduct formation in the oral cavity after drinking alcohol. Cancer Epidemiol biomarkers Prev. 2012;21:601-8.
https://doi.org/10.1158/1055-9965.EPI-11-1175
PMid:22301829 PMCid:PMC3319307

 

26. Ramdzan AN, Mornane PJ, McCullough MJ, Mazurek W, Kolev SD. Determination of acetaldehyde in saliva by gas-diffusion flow injection analysis. Anal Chim Acta. 2013;786:70-7.
https://doi.org/10.1016/j.aca.2013.05.021
PMid:23790294

 

27. Vakevainen S, Tillonen J, Agarwal DP, Srivastava N, Salaspuro M. High salivary acetaldehyde after a moderate dose of alcohol in ALDH2-deficient subjects: Sevidence for the local carcinogenic action of acetaldehyde. Alcohol Clin Exp Res. 2000;24:873-7.
https://doi.org/10.1111/j.1530-0277.2000.tb02068.x
PMid:10888077

 

28. Lachenmeier DW, Gumbel-Mako S, Sohnius EM, Keck-Wilhelm A, Kratz E, Mildau G. Salivary acetaldehyde increase due to alcohol-containing mouthwash use: A risk factor for oral cancer. Int J cancer. 2009;125:730-5.
https://doi.org/10.1002/ijc.24381
PMid:19444911

 

29. Lachenmeier DW, Monakhova YB. Short-term salivary acetaldehyde increase due to direct exposure to alcoholic beverages as an additional cancer risk factor beyond ethanol metabolism. J Exp Clin Cancer Res. 2011;30:3.
https://doi.org/10.1186/1756-9966-30-3
PMid:21211027 PMCid:PMC3022748

 

30. Ahrens W, Pohlabeln H, Foraita R, Nelis M, Lagiou P, Lagiou A, et al. Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: The ARCAGE study. Oral Oncol. 2014;50:616-25.
https://doi.org/10.1016/j.oraloncology.2014.03.001
PMid:24680035

 

31. Guha N, Boffetta P, Wunsch Filho V, Eluf Neto J, Shangina O, Zaridze D, et al. Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: Results of two multicentric case-control studies. Am J Epidemiol. 2007;166:1159-73.
https://doi.org/10.1093/aje/kwm193
PMid:17761691

 

32. Kocaelli H, Apaydin A, Aydil B, Ayhan M, Karadeniz A, Ozel S, et al. Evaluation of potential salivary acetaldehyde production from ethanol in oral cancer patients and healthy subjects. Hippokratia. 2014;18:269-74.

 

33. Moazzez R, Thompson H, Palmer RM, Wilson RF, Proctor GB, Wade WG. Effect of rinsing with ethanol-containing mouthrinses on the production of salivary acetaldehyde. Eur J Oral Sci. 2011;119:441-6.
https://doi.org/10.1111/j.1600-0722.2011.00886.x
PMid:22112029

 

34. Boffetta P, Hayes RB, Sartori S, Lee YC, Muscat J, Olshan A, et al. Mouthwash use and cancer of the head and neck: A pooled analysis from the International Head and Neck Cancer Epidemiology Consortium. Eur J Cancer Prev. 2016;25:344-8.
https://doi.org/10.1097/CEJ.0000000000000179
PMid:26275006 PMCid:PMC4752930

 

35. Zheng X, Bi C, Brooks DS. HHS Public Access. Anal Chem. 2015;25:368-79.

 

36. Seitz HK, Stickel F. Acetaldehyde as an underestimated risk factor for cancer development: Role of genetics in ethanol metabolism. Genes Nutr. 2010;5:121-8.
https://doi.org/10.1007/s12263-009-0154-1
PMid:19847467 PMCid:PMC2885165

 

37. Salaspuro M. Acetaldehyde as a common denominator and cumulative carcinogen in digestive tract cancers. Scand J Gastroenterol. 2009;44:912-25.
https://doi.org/10.1080/00365520902912563
PMid:19396661