Limones A, Sáez-Alcaide LM, Díaz-Parreño SA, Helm A, Bornstein MM, Molinero-Mourelle P. Medication-related osteonecrosis of the jaws (MRONJ) in cancer patients treated with denosumab VS. zoledronic acid: A systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal. 2020 May 1;25 (3):e326-36.
doi:10.4317/medoral.23324
https://dx.doi.org/doi:10.4317/medoral.23324
1. Vos T, Abajobir AA, Abbafati C, Abbas KM, Abate KH, Abd-Allah F, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390:1211-59. |
PMid:28919117 |
2. Coleman RE, Roodman, Smith, Body, Suva, Vessella. Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res. 2006;12:6243s-9s. |
PMid:17062708 |
3. Aghaloo TL, Felsenfeld AL, Tetradis S. Osteonecrosis of the Jaw in a Patient on Denosumab. J Oral Maxillofac Surg. 2010;68:959-63. |
PMid:20149510 PMCid:PMC2880179 |
4. Taylor KH, Middlefell LS, Mizen KD. Osteonecrosis of the jaws induced by anti-RANK ligand therapy. Br J Oral Maxillofac Surg. 2010;48:221-3. |
PMid:19836866 |
5. Malan J, Ettinger K, Naumann E, Beirne OR. The relationship of denosumab pharmacology and osteonecrosis of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:671-6. |
PMid:23159111 |
6. Bagan L, Jimenez Y, Leopoldo M, Murillo-Cortes J, Bagan J. Exposed necrotic bone in 183 patients with bisphosphonate-related osteonecrosis of the jaw: Associated clinical characteristics. Med Oral Patol Oral Cir Bucal. 2017;22:e582-5. |
PMid:28809382 PMCid:PMC5694180 |
7. Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, et al. American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw -- 2014 update. J Oral Maxillofac Surg. 2014;72:1938-56. |
PMid:25234529 |
8. King R, Tanna N, Patel V. Medication-related osteonecrosis of the jaw unrelated to bisphosphonates and denosumab - a review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;127:289-99. |
PMid:30713092 |
9. Yamagata K, Nagai H, Baba O, Uchida F, Kanno N, Hasegawa S, et al. A Case of Brain Abscess Caused by Medication-Related Osteonecrosis of the Jaw. Case Rep Dent. 2016;2016:7038618. |
PMid:26949551 PMCid:PMC4754463 |
10. Aghaloo T, Hazboun R, Tetradis S. Pathophysiology of Osteonecrosis of the Jaws. Oral Maxillofac Surg Clin North Am. 2015;27:489-96. |
PMid:26412796 PMCid:PMC4908822 |
11. McGowan K, McGowan T, Ivanovski S. Risk factors for medication-related osteonecrosis of the jaws: A systematic review. Oral Dis. 2018;24:527-36. |
PMid:28656643 |
12. Lombard T, Neirinckx V, Rogister B, Gilon Y, Wislet S. Medication-Related Osteonecrosis of the Jaw: New Insights into Molecular Mechanisms and Cellular Therapeutic Approaches. Stem Cells Int. 2016;2016:8768162. |
PMid:27721837 PMCid:PMC5046039 |
13. Zheng GZ, Chang B, Lin FX, Xie D, Hu QX, Yu GY, et al. Meta-analysis comparing denosumab and zoledronic acid for treatment of bone metastases in patients with advanced solid tumours. Eur J Cancer Care (Engl). 2017;26:1-7. |
PMid:27430483 |
14. Hortobagyi GN, Zheng M, Mohanlal R. Indirect Evaluation of Bone Saturation with Zoledronic Acid After Long-Term Dosing. Oncologist. 2019;24:178-84. |
PMid:30297386 PMCid:PMC6369945 |
15. Van Den Wyngaert T, Wouters K, Huizing MT, Vermorken JB. RANK ligand inhibition in bone metastatic cancer and risk of osteonecrosis of the jaw (ONJ): Non bis in idem? Support Care Cancer. 2011;19:2035-40. |
PMid:21203781 |
16. Qi W-X, Tang L-N, He A-N, Yao Y, Shen Z. Risk of osteonecrosis of the jaw in cancer patients receiving denosumab: A meta-analysis of seven randomized controlled trials. Int J Clin Oncol. 2014;19:403-10. |
PMid:23605142 |
17. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Int J Surg. 2010;8:336-41. |
PMid:20171303 |
18. Zintzaras E, Ioannidis JPA. Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol. 2005;28:123-37. |
PMid:15593093 |
19. Guyatt GH, Oxman AD, Schünemann HJ, Tugwell P, Knottnerus A. GRADE guidelines: A new series of articles in the Journal of Clinical Epidemiology. J Clin Epidemiol. 2011;64:380-2. |
PMid:21185693 |
20. Higgins JPT, Altman DG, Gotzsche PC, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. |
PMid:22008217 PMCid:PMC3196245 |
21. Ockerman A, Bornstein MM, Leung YY, Li SKY, Politis C, Jacobs R. Incidence of bleeding after minor oral surgery in patients on dual antiplatelet therapy: a systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2019;49:90-8. |
PMid:31248706 |
22. Anzures-Cabrera J, Higgins JPT. Graphical displays for meta-analysis: An overview with suggestions for practice. Res Synth Methods. 2010;1:66-80. |
PMid:26056093 |
23. Bax L, Yu L-M, Ikeda N, Tsuruta H, Moons KGM. Development and validation of MIX: Comprehensive free software for meta-analysis of causal research data. BMC Med Res Methodol. 2006;6:50. |
PMid:17038197 PMCid:PMC1626481 |
24. Stopeck AT, Lipton A, Body J-J, Steger GG, Tonkin K, De Boer RH, et al. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: A randomized, double-blind study. J Clin Oncol. 2010;28:5132-9. |
PMid:21060033 |
25. Fizazi K, Carducci M, Smith M, Damião R, Brown J, Karsh L, et al. Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: A randomised, double-blind study. Lancet. 2011;377:813-22. |
PMid:21353695 |
26. Henry DH, Costa L, Goldwasser F, Hirsh V, Hungria V, Prausova J, et al. Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. J Clin Oncol. 2011;29:1125-32. |
PMid:21343556 |
27. Lipton A, Fizazi K, Stopeck AT, Henry DH, Brown JE, Yardley DA, et al. Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: A combined analysis of 3 pivotal, randomised, phase 3 trials. Eur J Cancer. 2012;48:3082-92. |
PMid:22975218 |
28. Scagliotti G V, Hirsh V, Siena S, Henry DH, Woll PJ, Manegold C, et al. Overall survival improvement in patients with lung cancer and bone metastases treated with denosumab versus zoledronic acid: Subgroup analysis from a randomized phase 3 study. J Thorac Oncol. 2012;7:1823-9. |
PMid:23154554 |
29. Henry D, Vadhan-Raj S, Hirsh V, Von Moos R, Hungria V, Costa L, et al. Delaying skeletal-related events in a randomized phase 3 study of denosumab versus zoledronic acid in patients with advanced cancer: An analysis of data from patients with solid tumors. Support Care Cancer. 2014;22:679-87. |
PMid:24162260 |
30. Stopeck AT, Fizazi K, Body J-J, Brown JE, Carducci M, Diel I, et al. Safety of long-term denosumab therapy: results from the open label extension phase of two phase 3 studies in patients with metastatic breast and prostate cancer. Support Care Cancer. 2016;24:447-55. |
PMid:26335402 PMCid:PMC4669370 |
31. Stopeck AT, Fizazi K, Body J-J, Brown JE, Carducci M, Diel I, et al. Erratum to: Safety of long-term denosumab therapy: results from the open label extension phase of two phase 3 studies in patients with metastatic breast and prostate cancer. Support Care Cancer. 2016;24:447-55. |
PMid:26335402 PMCid:PMC4669370 |
32. Raje N, Terpos E, Willenbacher W, Shimizu K, García-Sanz R, Durie B, et al. Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study. Lancet Oncol. 2018;19:370-81. |
PMid:29429912 |
33. Loyson T, Van Cann T, Schöffski P, Clement PM, Bechter O, Spriet I, et al. Incidence of osteonecrosis of the jaw in patients with bone metastases treated sequentially with bisphosphonates and denosumab. Acta Clin Belgica Int J Clin Lab Med. 2018;73:100-9. |
PMid:28693379 |
34. Karna H, Gonzalez J, Radia HS, Sedghizadeh PP, Enciso R. Risk-reductive dental strategies for medication related osteonecrosis of the jaw among cancer patients: A systematic review with meta-analyses. Oral Oncol. 2018;85:15-23. |
PMid:30220314 |
35. Owosho AA, Liang STY, Sax AZ, Wu K, Yom SK, Huryn JM, et al. Medication-related osteonecrosis of the jaw: An update on the memorial sloan kettering cancer center experience and the role of premedication dental evaluation in prevention. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125:440-5. |
PMid:29580668 |
36. Stavropoulos A, Bertl K, Pietschmann P, Pandis N, Schiødt M, Klinge B. The effect of antiresorptive drugs on implant therapy: Systematic review and meta-analysis. Clin Oral Implants Res. 2018;29:54-92. |
PMid:30306695 |