1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre, LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A cancer journal for clinicians. 2018;68:394-424.

https://doi.org/10.3322/caac.21492

PMid:30207593 

2. Rivera C. Essentials of oral cancer. Int J Clin Exp Pathol. 2015;8:11884-94.

PMid:26617944

3. Chi AC, Day TA, Neville BW. Oral cavity and oropharyngeal squamous cell carcinoma--an update. CA:A cancer journal for clinicians. 2015;65:401-21.

https://doi.org/10.3322/caac.21293

PMid:26215712 

4. Rivera C, Oliveira AK, Pereira RA, De Rossi T, Paes Leme A. Prognostic biomarkers in oral squamous cell carcinoma: A systematic review. Oral Oncology. 2017;72:38-47.

https://doi.org/10.1016/j.oraloncology.2017.07.003

PMid:28797460 

5. Retzbach E, Sheehan S, Nevel E, Batra A, Phi T, Nguyen A, et al. Podoplanin emerges as a functionally relevant oral cancer biomarker and therapeutic target. Oral Oncology. 2018;78:126-36.

https://doi.org/10.1016/j.oraloncology.2018.01.011

PMid:29496040 

6. de Vicente JC, Rodrigo JP, Rodriguez-Santamarta T, Lequerica-Fernandez P, Allonca E, Garcia-Pedrero JM. Podoplanin expression in oral leukoplakia: tumorigenic role. Oral Oncology. 2013;49:598-603.

https://doi.org/10.1016/j.oraloncology.2013.02.008

PMid:23473850 

7. Habiba U, Kitamura T, Yanagawa-Matsuda A, Higashino F, Hida K, Totsuka Y, Shindoh M. HuR and podoplanin expression is associated with a high risk of malignant transformation in patients with oral preneoplastic lesions. Oncology Letters. 2016;12:3199-207.

https://doi.org/10.3892/ol.2016.5061

PMid:27899983 PMCid:PMC5103919

8. Wicki A, Lehembre F, Wick N, Hantusch B, Kerjaschki D, Christofori G. Tumor invasion in the absence of epithelialmesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell. 2006;9:261-72.

https://doi.org/10.1016/j.ccr.2006.03.010

PMid:16616332 

9. Hwang YS, Xianglan Z, Park KK, Chung WY. Functional invadopodia formation through stabilization of the PDPN transcript by IMP-3 and cancer-stromal crosstalk for PDPN expression. Carcinogenesis. 2012;33:2135-46.

https://doi.org/10.1093/carcin/bgs258

PMid:22859271 

10. Koontongkaew S. The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas. Journal of Cancer. 2012;4:66-83.

https://doi.org/10.7150/jca.5112

PMid:23386906 PMCid:PMC3564248

11. Lucio PS, Cavalcanti AL, Alves PM, Godoy GP, Nonaka CF. Myofibroblasts and their relationship with oral squamous cell carcinoma. Brazilian Journal Otorhinolaryngology. 2013;79:112-8.

https://doi.org/10.5935/1808-8694.20130019

PMid:23503917 

12. Kellermann MG, Sobral LM, da Silva SD, Zecchin KG, Graner E, Lopes MA, et al. Myofibroblasts in the stroma of oral squamous cell carcinoma are associated with poor prognosis. Histopathology. 2007;51:849-53.

https://doi.org/10.1111/j.1365-2559.2007.02873.x

PMid:18042073 

13. Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, et al. Stromal features are predictive of disease mortality in oral cancer patients. The Journal of Pathology. 2011;223:470-81.

https://doi.org/10.1002/path.2830

PMid:21294121 

14. Li YY, Zhou CX, Gao Y. Interaction between oral squamous cell carcinoma cells and fibroblasts through TGF-β1 mediated by podoplanin. Experimental Cell Research. 2018;369:43-53.

https://doi.org/10.1016/j.yexcr.2018.04.029

PMid:29719198 

15. Ding L, Zhang Z, Shang D, Cheng J, Yuan H, Wu Y, et al. α-Smooth muscle actin-positive myofibroblasts, in association with epithelial-mesenchymal transition and lymphogenesis, is a critical prognostic parameter in patients with oral tongue squamous cell carcinoma. Journal of Oral Pathology & Medicine. 2014;43:335-43.

https://doi.org/10.1111/jop.12143

PMid:24313357 

16. Fujii N, Shomori K, Shiomi T, Nakabayashi M, Takeda C, Ryoke K, et al. Cancer-associated fibroblasts and CD163.positive macrophages in oral squamous cell carcinoma: their clinicopathological and prognostic significance. Journal of Oral Pathology & Medicine. 2012;41:444-51.

https://doi.org/10.1111/j.1600-0714.2012.01127.x

PMid:22296275 

17. Yuan P, Temam S, El-Naggar A, Zhou X, Liu DD, Lee JJ, et al. Overexpression of podoplanin in oral cancer and its association with poor clinical outcome. Cancer. 2006;107:563-9.

https://doi.org/10.1002/cncr.22061

PMid:16804930 

18. Cohen N, Fedewa S, Chen A. Epidemiology and demographics of the head and neck cancer population. Oral and Maxillofacial Surgery Clinics of North America. 2018;30:381-95.

https://doi.org/10.1016/j.coms.2018.06.001

PMid:30078696 

19. De Boeck A, Narine K, De Neve W, Mareel M, Bracke M, De Wever O. Resident and bone marrow-derived mesenchymal stem cells in head and neck squamous cell carcinoma. Oral Oncology. 2010;46:336-42.

https://doi.org/10.1016/j.oraloncology.2010.01.016

PMid:20219413 

20. Lin NN, Wang P, Zhao D, Zhang FJ, Yang K, Chen R. Significance of oral cancer-associated fibroblasts in angiogenesis, lymphangiogenesis, and tumor invasion in oral squamous cell carcinoma. Journal of Oral Pathology & Medicine. 2017;46:21-30.

https://doi.org/10.1111/jop.12452

PMid:27229731 

21. Wang J, Min A, Gao S, Tang Z. Genetic regulation and potentially therapeutic application of cancer-associated fibroblasts in oral cancer. Journal of Oral Pathology & Medicine. 2014;43:323-34.

https://doi.org/10.1111/jop.12098

PMid:23782231 

22. Dourado MR, Guerra ENS, Salo T, Lambert DW, Coletta RD. Prognostic value of the immunohistochemical detection of cancer-associated fibroblasts in oral cancer: A systematic review and meta-analysis. Journal of Oral Pathology & Medicine. 2018;47:443-53.

https://doi.org/10.1111/jop.12623

PMid:28782893 

23. Takahashi H, Sakakura K, Kudo T, Toyoda M, Kaira K, Oyama, T, Chikamatsu K. Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages. Oncotarget. 2017;8:8633-47.

https://doi.org/10.18632/oncotarget.14374

PMid:28052009 PMCid:PMC5352428

24. Hanley CJ, Mellone M, Ford K, Thirdborough SM, Mellows T, Frampton SJ, et al. Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4. Journal of the National Cancer Institute. 2018;110:109-20.

https://doi.org/10.1093/jnci/djx121

PMid:28922779 PMCid:PMC5903651

25. Kumar D, New J, Vishwakarma V, Joshi R, Enders J, Lin F, et al. Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression. Cancer Research. 2018;78:3769-82.

https://doi.org/10.1158/0008-5472.CAN-17-1076

PMid:29769197 PMCid:PMC6050074

26. AG D, Janardanan-Nair B, BR V. Podoplanin expression in oral potentially malignant disorders and oral squamous cell carcinoma. J Clin Exp Dent. 2017;9:e1418-24.

PMid:29410757 PMCid:PMC5794119

27. Chen G, Xu R, Yue B, Mei X, Li P, Zhow X, et al. The expression of podoplanin protein is a diagnostic marker to distinguish the early infiltration of esophageal squamous cell carcinoma. Oncotarget. 2017;8:19013-20.

https://doi.org/10.18632/oncotarget.14596

PMid:28086225 PMCid:PMC5386665

28. Ibrahim BB, Salem MM, Khairy RA, Al Gunaid R. Expression of Podoplanin in Laryngeal Squamous Cell Carcinoma and Dysplasia. Journal of clinical and diagnostic research. 2017;11:EC31-5.

https://doi.org/10.7860/JCDR/2017/25939.9882

PMid:28658769 PMCid:PMC5483671

29. Kim HY, Rha KS, Shim GA, Kim JH, Kim JM, Huang SM, et al. Podoplanin is involved in the prognosis of head and neck squamous cell carcinoma through interaction with VEGF-C. Oncology Reports. 2015;34:833-42.

https://doi.org/10.3892/or.2015.4070

PMid:26081937 

30. Rodrigo JP, Garcia-Carracedo D, Gonzalez MV, Mancebo G, Fresno MF, Garcia-Pedrero J. Podoplanin expression in the development and pregression of laryngeal squamous cell carcinomas. Molecular Cancer. 2010;2:48.

https://doi.org/10.1186/1476-4598-9-48

PMid:20196862 PMCid:PMC2841121

31. Preuss SF, Anagiotos A, Seuthe IM, Drebber U, Wedemeyer I, Kreppel M, et al. Expression of podoplanin and prognosis in oropharyngeal cancer. European Archives of Otorhinolaryngology. 2015;272:1749-54.

https://doi.org/10.1007/s00405-014-3105-4

PMid:24880471 

32. Neri S, Ishii G, Taira T, Hishida T, Yoshida J, Nishimura M, et al. Recruitment of podoplanin positive cancer-associated fibroblasts in metastatic lymph nodes predicts poor prognosis in pathological N2 stage III lung adenocarcinoma. Annals of Surgical Oncology. 2012;19:3953-62.

https://doi.org/10.1245/s10434-012-2421-4

PMid:22669451 

33. Schoppmann SF, Berghoff A, Dinhof C, Jakesz R, Gnant M, Dubsky P, et al. Podoplaninexpressing cancer-associated fibroblasts are associated with poor prognosis in invasive breast cancer. Breast Cancer Research and Treatment. 2012;134:237-44.

https://doi.org/10.1007/s10549-012-1984-x

PMid:22350732