1. Friedman JW. The prophylactic extraction of third molars: a public health hazard. Am J Public Health. 2007;97:1554.

https://doi.org/10.2105/AJPH.2006.100271

PMid:17666691 PMCid:PMC1963310

2. Lee CT, Zhang S, Leung YY, Li SK, Tsang CC, Chu CH. Patients' satisfaction and prevalence of complications on surgical extraction of third molar. Patient Prefer Adherence. 2015;9:257-63.

https://doi.org/10.2147/PPA.S76236

PMid:25709411 PMCid:PMC4332291

3. Cobo-Vázquez C, Fernández-Tresguerres I, Ortega-Aranegui R, López- Quiles J. Effects of local melatonin application on post-extraction sockets after third molar surgery. A pilot study. Med Oral Patol Oral Cir Bucal. 2014;19:e628-33.

https://doi.org/10.4317/medoral.19851

PMid:25350595 PMCid:PMC4259382

4. Bouloux GF, Steed MB, Perciaccante VJ. Complications of third molar surgery. Oral Maxillofac Surg Clin North Am. 2007;19:117-28.

https://doi.org/10.1016/j.coms.2006.11.013

PMid:18088870 

5. Caso A, Hung LK, Beirne OR. Prevention of alveolar osteitis with chlorhexidine: a meta-analytic review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:155-9.

https://doi.org/10.1016/j.tripleo.2004.05.009

PMid:15660084 

6. Zhou J, Hu B, Liu Y, Yang Z, Song J. The efficacy of intra-alveolar 0.2% chlorhexidine gel on alveolar osteitis: a meta-analysis. Oral Dis. 2017;23:598-608.

https://doi.org/10.1111/odi.12553

PMid:27479137 

7. Torres-Lagares D, Infante-Cossio P, Gutierrez-Perez JL, Romero-Ruiz MM, Garcia-Calderon M, Serrera-Figallo MA. Intra-alveolar chlorhexidine gel for the prevention of dry socket in mandibular third molar surgery. A pilot study. Med Oral Patol Oral Cir Bucal. 2006;11:179-84.

PMid:16505800

8. Rubio-Palau J, Garcia-Linares J, Hueto-Madrid JA, Gonzalez-Lagunas J, Raspall-Martin G, Mareque-Bueno J. Effect of intra-alveolar placement of 0.2% chlorhexidine bioadhesive gel on the incidence of alveolar osteitis following the extraction of mandibular third molars. A double-blind randomized clinical trial. Med Oral Patol Oral Cir Bucal. 2015;20:e117-22.

https://doi.org/10.4317/medoral.20009

PMid:25475772 PMCid:PMC4320414

9. Eshghpour M, Danaeifar N, Kermani H, Nejat AH. Does Intra-Alveolar Application of chlorhexidine gel in combination with platelet-rich fibrin have an advantage over application of platelet-Rich fibrin in decreasing alveolar osteitis after mandibular third molar surgery? A double-blinded randomized clinical trial. J Oral Maxillofac Surg. 2018;76:939.

https://doi.org/10.1016/j.joms.2017.12.009

PMid:29316445 

10. Cho H, Lynham AJ, Hsu E. Postoperative interventions to reduce inflammatory complications after third molar surgery: review of the current evidence. Aust Dent J. 2017;62:412-9.

https://doi.org/10.1111/adj.12526

PMid:28498604 

11. Cicciù M, Fiorillo L, Cervino G. Chitosan Use in Dentistry: A Systematic Review of Recent Clinical Studies. Mar Drugs. 2019;17:e417.

https://doi.org/10.3390/md17070417

PMid:31319609 PMCid:PMC6669505

12. Lopez-Lopez J, Jan-Palli E, Gonzalez-Navarro B, Jane-Salas E, Estrugo-Devesa A, Milani M. Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery. Curr Med Res Opin. 2015;31:2179-83.

https://doi.org/10.1185/03007995.2015.1108909

PMid:26471464 

13. Madrazo-Jiménez M, Rodríguez-Caballero Á, Serrera-Figallo MÁ, Garrido-Serrano R, Gutiérrez-Corrales A, Gutiérrez-Pérez JL, et al. The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction. Med Oral Patol Oral Cir Bucal. 2016;21:e696-702.

https://doi.org/10.4317/medoral.21281

PMid:27475700 PMCid:PMC5116111

14. Malmquist JP, Clemens SC, Oien HJ, Wilson SL. Hemostasis of oral surgery wound with the HemCon Dental Dressing. J Oral Maxillofac Surg. 2008;66:1177-83.

https://doi.org/10.1016/j.joms.2007.12.023

PMid:18486782 

15. Schulz KF, Altman DG, Moher D, Group C. CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. BMC Med. 2010;8:18.

https://doi.org/10.1186/1741-7015-8-18

PMid:20334633 PMCid:PMC2860339

16. Small LT, Lampkin M, Vural E, Moreno MA. American Society of Anesthesiologists Class as Predictor for Perioperative Morbidity in Head and Neck Free Flaps. Otolaryngol Head Neck Surg. 2019;161:91-7.

https://doi.org/10.1177/0194599819832812

PMid:30912990 

17. Sainz de Baranda B, Silvestre FJ, Silvestre-Rangil J. Relationship between surgical difficulty of third molar extraction under local anesthesia and the postoperative evolution of clinical and blood parameters. J Oral Maxillofac Surg. 2019;77:1337-45.

https://doi.org/10.1016/j.joms.2019.02.020

PMid:30878593 

18. Haraji A, Rakhshan V, Khamverdi N, Alishahi HK. Effects of intra-alveolar placement of 0.2% chlorhexidine bioadhesive gel on dry socket incidence and postsurgical pain: a double-blind split-mouth randomized controlled clinical trial. J Orofac Pain. 2013;27:256-62.

https://doi.org/10.11607/jop.1142

PMid:23882458 

19. Amin MM, Laskin DM. Prophylactic use of indometacin for prevention of postsurgical complications after removal of impacted third molars. Oral Surg. 1983;55:448-51.

https://doi.org/10.1016/0030-4220(83)90227-X

PMid:6575332

20. Blum IR. Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review. Int J Oral Maxillofac Surg. 2002;31:309-17.

https://doi.org/10.1054/ijom.2002.0263

PMid:12190139 

21. Bello SA, Adeyemo WL, Bamgbose BO, Obi EV, Adeyinka AA. Effect of age, impaction types and operative time on inflammatory tissue reactions following lower third molar surgery. Head Face Med. 2011;7:8-16.

https://doi.org/10.1186/1746-160X-7-8

PMid:21527036 PMCid:PMC3114767

22. Rodríguez Sánchez F, Rodríguez Andrés C, Arteagoitia Calvo I. Does chlorhexidine prevent alveolar osteitis after third molar extractions? Systematic review and meta-analysis. J Oral Maxillofac Surg. 2017;75:901-14.

https://doi.org/10.1016/j.joms.2017.01.002

PMid:28189661 

23. Thesome A. The efficacy of chlorhexidine gel in the prevention of alveolar osteitis after mandibular third molar extraction: a systematic review and meta-analysis. BMC Oral Health. 2017;17:82.

https://doi.org/10.1186/s12903-017-0376-3

PMid:28526078 PMCid:PMC5437629

24. Shariatinia Z, Jalali A. Chitosan-based hydrogels: Preparation, properties and applications. Int J Biol Macro. 2018;115:194-220.

https://doi.org/10.1016/j.ijbiomac.2018.04.034

PMid:29660456 

25. Ebner F, Heller A, Rippke F, Tausch I. Topical use of dexpanthenol in skin disorders. Am J Clin Dermatol. 2002;3:427-33.

https://doi.org/10.2165/00128071-200203060-00005

PMid:12113650 

26. Flötra L, Gjermo P, Rölla G, Waerhaug J. Side effects of hlorhexidine mouth washes. Scand J Dent Res. 1971;79:119-25.

https://doi.org/10.1111/j.1600-0722.1971.tb02001.x

PMid:5280246 

27. Koray M, Ofluoglu D, Onal EA, Ozgul M, Ersev H, Yaltirik M, et al. Efficacy of hyaluronic acid spray on swelling, pain, and trismus after surgical extraction of impacted mandibular third molars. Int J Oral Maxillofac Surg. 2014;43:1399-403.

https://doi.org/10.1016/j.ijom.2014.05.003

PMid:24924267 

28. Hasheminia D, Moaddabi A, Moradi S, Soltani P, Moannaei M, Issazadeh M. The efficacy of 1% Betadine mouthwash on the incidence of dry socket after mandibular third molar surgery. J Clin Exp Dent. 2018;10:e445-9.

https://doi.org/10.4317/jced.54444

PMid:29849968 PMCid:PMC5971076

29. Giammarinaro E, Cosola S, Oldoini G, Gulia F, Peñarrocha-Oltra D, Marconcini S, et al. Local formula with mucoadhesive propery: A randomized clinical trial of a therapeutic agent for the treatment of oral apthous ulcers. J Contemp Dent Pract. 2019;20:1249-53.

https://doi.org/10.5005/jp-journals-10024-2709

PMid:31892674 

30. Cosola S, Giammarinaro E, Marconcini S, Lelli M, Lorenzi C, Genovesi AM. Prevention of bacterial colonization on suture threads after oral surgery: comparison between propolis- and chlorhexidine-based formulae. J Biol Regul Homeost Agent. 2019;33:1275-81.

PMid:31298019