Gutiérrez-Vargas R, Villasis-Keever MÁ, Portilla-Robertson J, Ascencio-Montiel IDJ, Zapata-Tarrés M. Effect of zinc on oropharyngeal mucositis in children with acute leukemia undergoing chemotherapy. Med Oral Patol Oral Cir Bucal. 2020 Nov 1;25 (6):e791-8.


doi:10.4317/medoral.23798

https://dx.doi.org/doi:10.4317/medoral.23798


1. Velten DB, Zandonade E, Monteiro de Barros Miotto MH. Prevalence of oral manifestations in children and adolescents with cancer submitted to chemotherapy. BMC Oral Health. 2017;17:49.

https://doi.org/10.1186/s12903-016-0331-8

PMid:28109192 PMCid:PMC5251332

2. Ruiz-Esquide G NB, Vargas A, Maíz A. Tratamiento y prevención de la mucositis oral asociada al tratamiento del cáncer. Rev Med Chile. 2011;139:373-81.

https://doi.org/10.4067/S0034-98872011000300015

PMid:21879172 

3. Tian X, Chen WQ, Liu XL, Pi YP, Chen H. Efficacy and safety of oral zinc sulfate in the prevention of chemotherapy-induced oral mucositis. Medicine. 2018;97:e10839.

https://doi.org/10.1097/MD.0000000000010839

PMid:29794779 PMCid:PMC6392683

4. Tian X, Liu XL, Pi YP, Chen H, Chen WQ. Oral Zinc Sulfate for Prevention and Treatment of Chemotherapy-Induced Oral Mucositis: A Meta-Analysis of Five Randomized Controlled Trials. Front Oncol. 2018;8:484.

https://doi.org/10.3389/fonc.2018.00484

PMid:30510915 PMCid:PMC6252385

5. Ribeiro ILA, Limeira RRT, Dias de Castro R, Ferreti Bonan PR, Valença AMG. Oral Mucositis in Pediatric Patients in Treatment for Acute Lymphoblastic Leukemia. Int J Environ Res Public Health. 2017;14:1468.

https://doi.org/10.3390/ijerph14121468

PMid:29182564 PMCid:PMC5750887

6. Okada T, Nakajima Y, Nishikage T, Ryotokuji T, Miyawaki Y, Hoshino A, et al. A prospective study of nutritional supplementation for preventing oral mucositis in cancer patients receiving chemotherapy. Asia Pac J Clin Nutr. 2017;26:42-8.

PMid:28049260

7. Gomes AOF, Silva Junior A, Noce CW, Ferreira M, Maiolino A, Torres SR. The frequency of oral conditions detected in hematology inpatients. Hematol Transfus Cell Ther. 2018;40:240-4.

https://doi.org/10.1016/j.htct.2018.02.006

PMid:30128432 PMCid:PMC6098180

8. Garrocho-Rangel JA, Herrera-Moncada M, Márquez-Preciado R, Tejeda-Nava F, Ortiz-Zamudio JJ, Pozos-Guillén A. Oral mucositis in paediatric acute Iymphoblastic leukemia patients receiving methotrexate-based chemotherapy: case series. Eur J Paediatr Dent. 2018;19:239-42.

PMid:30063158

9. Chaitanya NC, Shugufta K, Suvarna C, Bhopal T, Mekala S, Ponnuru H, et al. A Meta-Analysis on the Efficacy of Zinc in Oral Mucositis during Cancer Chemo and/or Radiotherapy-An Evidence-Based Approach. J Nutr Sci Vitaminol. 2019;65:184-91.

https://doi.org/10.3177/jnsv.65.184

PMid:31061288 

10. Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014;120:1453-61.

https://doi.org/10.1002/cncr.28592

PMid:24615748 PMCid:PMC4164022

11. Cidon EU. Chemotherapy induced oral mucositis: prevention is possible. Chin Clin Oncol. 2018;7:6.

https://doi.org/10.21037/cco.2017.10.01

PMid:29156889 

12. Sung L, Robinson P, Treister N, Baggott T, Gibson P, Tissing W, et al. Guideline for the prevention of oral and oropharyngeal mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation. BMJ Support Palliat Care. 2017;7:7-16.

https://doi.org/10.1136/bmjspcare-2014-000804

PMid:25818385 PMCid:PMC5339548

13. Shuai T, Yi LJ, Tian X, Chen WQ, Chen H, Li XE. Prophylaxis with oral zinc sulfate against radiation-induced oropharyngeal mucositis in patients with head and neck cancer: Protocol for a meta-analysis of randomized controlled trials. Medicine. 2018;97:e13310.

https://doi.org/10.1097/MD.0000000000013310

PMid:30508920 PMCid:PMC6283232

14. Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, et al. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer.2004;100:1995-2025.

https://doi.org/10.1002/cncr.20162

PMid:15108222 

15. Chaveli-López B, Bagán-Sebastián JV. Treatment of oral mucositis due to chemotherapy. J Clin Exp Dent. 2016;8:e201-9.

https://doi.org/10.4317/jced.52917

PMid:27034762 PMCid:PMC4808317

16. Riley P, Glenny AM, Worthington HV, Littlewood A, Fernandez Mauleffinch LM, Clarkson JE, et al. Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors. Cochrane Database Syst Rev. 2017;11:CD011990.

https://doi.org/10.1002/14651858.CD011990.pub2

PMid:29181845 PMCid:PMC6486203

17. Arbadi-Kalati F, Arbabi-kalati F, Deghatipour M, Ansari Moghadam A. Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: a double-blind randomized clinical trial. Arch Iran Med. 2012;15:413-17.

PMid:22724877

18. Mansouri A, Hadjibabaie M, Iravani M, Shamshiri AR, Hayatshahi A, Javadi MR, et al. The effect of zinc sulfate in the prevention of high-dose chemotherapy-induced mucositis: a double-blind, randomized, placebo-controlled study. Hematol Oncol. 2012;30:22-6.

https://doi.org/10.1002/hon.999

PMid:21692101 

19. Peterson DE, Boers-Doets CB, Bensadoun RJ, Herrstedt J, ESMO Guidelines Committee. Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelines for diagnosis, treatment, and follow-up. Ann Oncol. 2015;26:v139-51.

https://doi.org/10.1093/annonc/mdv202

PMid:26142468 

20. Cheng KK, Molassiotis A, Chang AM, Wai WC, Cheung SS. Evaluation of an oral care protocol intervention in the prevention of chemotherapy-induced oral mucositis in paediatric cancer patients. Eur J Cancer. 2001;37:2056-63.

https://doi.org/10.1016/S0959-8049(01)00098-3

PMid:11597384

21. Kim J, Kim S, Jeon S, Hui Z, Kim Y, Im Y, et al. Anti-inflammatory effects of zinc in PMA-treated human gingival fibroblast cells. Med Oral Patol Oral Cir Bucal. 2015;20:el80-7.

https://doi.org/10.4317/medoral.19896

PMid:25662537 PMCid:PMC4393980

22. Thomsen M, Vitetta L. Adjunctive Treatments for the Prevention of Chemotherapy- and Radiotherapy-Induced Mucositis. Integr Cancer Ther. 2018;17:1027-47.

https://doi.org/10.1177/1534735418794885

PMid:30136590 PMCid:PMC6247548

23. Rambod M, Pasyar N, Ramzi M. The effect of zinc sulfate on prevention, incidence, and severity of mucositis in leukemia patients undergoing chemotherapy. Eur J Oncol Nurs. 2018;33:14-21.

https://doi.org/10.1016/j.ejon.2018.01.007

PMid:29551172 

24. Curra M, Soares Junior LAV, Martins MD, Santos PSDS. Chemotherapy protocols and incidence of oral mucositis. An integrative review. Einstein (Sao Paulo). 2018;16:eRW4007.

https://doi.org/10.1590/s1679-45082018rw4007

PMid:29694618 PMCid:PMC5968807

25. Cheng KK, Lee V, Li CH, Goggins W, Thompson DR, Yuen HL, et al. Incidence and risk factors of oral mucositis in paediatric and adolescent patients undergoing chemotherapy. Oral Oncol. 2011;47:153-62.

https://doi.org/10.1016/j.oraloncology.2010.11.019

PMid:21220206 

26. Bishop JF, Lowenthal RM, Joshua D, Matthews JP, Todd D, Cobcroft R, et al. Etoposide in acute nonlymphocytic leukemia. Australian Leukemia Study Group. Blood. 1990;75:27-32.

https://doi.org/10.1182/blood.V75.1.27.27

PMid:2403818