Monteiro L, Silva P, Delgado L, Amaral B, Garcês F, Salazar F, et al. Expression of spindle assembly checkpoint proteins BubR1 and Mad2 expression as potential biomarkers of malignant transformation of oral leukoplakia: an observational cohort study. Med Oral Patol Oral Cir Bucal. 2021 Nov 1;26 (6):e719-28.
doi:10.4317/medoral.24511
https://dx.doi.org/doi:10.4317/medoral.24511
1. Miranda-Filho A, Bray F. Global patterns and trends in cancers of the lip, tongue and mouth. Oral Oncol. 2020;102:104551. |
PMid:31986342 |
2. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2009;45:309-16. |
PMid:18804401 |
3. Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles M, Kerr AR, et al. Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer. Oral Dis. 2020. |
PMid:33128420 |
4. Gaykalova DA, Mambo E, Choudhary A, Houghton J, Buddavarapu K, Sanford T, et al. Novel insight into mutational landscape of head and neck squamous cell carcinoma. PLoS One. 2014;9:e93102. |
PMid:24667986 PMCid:PMC3965530 |
5. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-74. |
PMid:21376230 |
6. Nikitakis NG, Pentenero M, Georgaki M, Poh CF, Peterson DE, Edwards P, et al. Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125:650-69. |
PMid:29709496 |
7. Chai AWY, Lim KP, Cheong SC. Translational genomics and recent advances in oral squamous cell carcinoma. Semin Cancer Biol. 2020;61:71-83. |
PMid:31542510 |
8. Farah CS. Molecular, genomic and mutational landscape of oral leukoplakia. Oral Diseases. 2021;27:803-12. |
PMid:33448555 |
9. Teixeira JH, Silva P, Faria J, Ferreira I, Duarte P, Delgado ML, et al. Clinicopathologic significance of BubR1 and Mad2 overexpression in oral cancer. Oral Dis. 2015;21:713-20. |
PMid:25754611 |
10. Griffis ER, Stuurman N, Vale RD. Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore. J Cell Biol. 2007;177:1005-15. |
PMid:17576797 PMCid:PMC2064361 |
11. Silva PMA, Delgado ML, Ribeiro N, Florindo C, Tavares ÁA, Ribeiro D, et al. Spindly and Bub3 expression in oral cancer: Prognostic and therapeutic implications. Oral Dis. 2019;25:1291-301. |
PMid:30866167 |
12. Kujan O, Oliver RJ, Khattab A, Roberts SA, Thakker N, Sloan P. Evaluation of a new binary system of grading oral epithelial dysplasia for prediction of malignant transformation. Oral Oncol. 2006;42:987-93. |
PMid:16731030 |
13. Chaturvedi AK, Udaltsova N, Engels EA, Katzel JA, Yanik EL, Katki HA, et al. Oral Leukoplakia and Risk of Progression to Oral Cancer: A Population-Based Cohort Study. J Natl Cancer Inst. 2020;112:1047-54. |
PMid:31860085 PMCid:PMC7566351 |
14. Villa A, Celentano A, Glurich I, Borgnakke WS, Jensen SB, Peterson DE, et al. World Workshop on Oral Medicine VII: Prognostic biomarkers in oral leukoplakia: A systematic review of longitudinal studies. Oral Dis. 2019;25 Suppl 1:64-78. |
PMid:31140698 PMCid:PMC6544170 |
15. Monteiro L, Mello FW, Warnakualsuryia S. Tissue Biomarkers for Predicting the Risk of Oral Cancer in Patients Diagnosed with Oral Leukoplakia. A Systematic Review. Oral Dis. 2020. |
PMid:33290585 |
16. Choi JW, Kim Y, Lee JH, Kim YS. High expression of spindle assembly checkpoint proteins CDC20 and MAD2 is associated with poor prognosis in urothelial bladder cancer. Virchows Arch. 2013;463:681-7. |
PMid:23995871 |
17. McGrogan B, Phelan S, Fitzpatrick P, Maguire A, Prencipe M, Brennan D, et al. Spindle assembly checkpoint protein expression correlates with cellular proliferation and shorter time to recurrence in ovarian cancer. Hum Pathol. 2014;45:1509-19. |
PMid:24792619 |
18. Hsieh PC, Chen YK, Tsai KB, Shieh TY, Chang YY, Chang JG, et al. Expression of BUBR1 in human oral potentially malignant disorders and squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:257-67. |
PMid:19926498 |
19. Sravya T, Sivaranjani Y, Rao GV. Immunohistochemical expression of budding uninhibited by benzimidazole related 1 in leukoplakia and oral squamous cell carcinoma. J Oral Maxillofac Pathol. 2016;20:71-7. |
PMid:27194865 PMCid:PMC4860940 |
20. Chou CK, Wu CY, Chen JY, Ng MC, Wang HM, Chen JH, et al. BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9. Int J Mol Sci. 2015;16:15104-17. |
PMid:26151845 PMCid:PMC4519889 |
21. Warnakulasuriya S, Kovacevic T, Madden P, Coupland VH, Sperandio M, Odell E, et al. Factors predicting malignant transformation in oral potentially malignant disorders among patients accrued over a 10-year period in South East England. J Oral Pathol Med. 2011;40:677-83. |
PMid:21762430 |
22. Speight PM, Khurram SA, Kujan O. Oral potentially malignant disorders: risk of progression to malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125:612-27. |
PMid:29396319 |
23. Dost F, Le Cao KA, Ford PJ, Farah CS. A retrospective analysis of clinical features of oral malignant and potentially malignant disorders with and without oral epithelial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116:725-33. |
PMid:24144993 |
24. Hannisdal K, Burum-Auensen E, Schjølberg A, De Angelis PM, Clausen OPF. Correlation between reduced expression of the spindle checkpoint protein BubR1 and bad prognosis in tonsillar carcinomas. Head Neck. 2010;32:1354-62. |
PMid:20146332 |
25. Lira RCP, Miranda FA, Guimarães MCM, Simões RT, Donadi EA, Soares CP, et al. BUBR1 expression in benign oral lesions and squamous cell carcinomas: correlation with human papillomavirus. Oncol Rep. 2010;23:1027-36. |
PMid:20204288 |
26. Rizzardi C, Torelli L, Barresi E, Schneider M, Canzonieri V, Biasotto M, et al. BUBR1 expression in oral squamous cell carcinoma and its relationship to tumor stage and survival. Head Neck. 2011;33:727-33. |
PMid:21069850 |
27. Zhang X, Kim KY, Zheng Z, Bazarsad S, Kim J. Nomogram for risk prediction of malignant transformation in oral leukoplakia patients using combined biomarkers. Oral Oncol. 2017;72:132-9. |
PMid:28797449 |
28. Kawakami M, Liu X, Dmitrovsky E. New Cell Cycle Inhibitors Target Aneuploidy in Cancer Therapy. Annu Rev Pharmacol Toxicol. 2019;59:361-77. |
PMid:30110577 |
29. Silva PMA, Ribeiro N, Lima RT, Andrade C, Diogo V, Teixeira J, et al. Suppression of spindly delays mitotic exit and exacerbates cell death response of cancer cells treated with low doses of paclitaxel. Cancer Lett. 2017;394:33-42. |
PMid:28249757 |
30. Janssen A, Kops GJPL, Medema RH. Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. Proc Natl Acad Sci U S A. 2009;106:19108-13. |
PMid:19855003 PMCid:PMC2776415 |