1. Brunotto M, Zarate AM, Bono A, Barra JL, Berra S. Risk genes in head and neck cancer: a systematic review and meta-analysis of last 5 years. Oral Oncol. 2014;50:178-88.

https://doi.org/10.1016/j.oraloncology.2013.12.007

PMid:24370206 

2. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209-49.

https://doi.org/10.3322/caac.21660

PMid:33538338 

3. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-74.

https://doi.org/10.1016/j.cell.2011.02.013

PMid:21376230 

4. Bonacquisti E, Nguyen J. Connexin 43 (Cx43) in cancer: Implications for therapeutic approaches via gap junctions. Cancer Letters. 2019;442:439-44.

https://doi.org/10.1016/j.canlet.2018.10.043

PMid:30472182 

5. Jing Y, Zhou Q, Zhu H, Zhang Y, Song Y, Zhang X, et al. Ki-67 is an independent prognostic marker for the recurrence and relapse of oral squamous cell carcinoma. Oncol Lett. 2019;17:974-80.

https://doi.org/10.3892/ol.2018.9647

PMid:30655856

6. Campbell KJ, Tait SWG. Targeting BCL-2 regulated apoptosis in cancer. Open Biol. 2018;8:180002.

https://doi.org/10.1098/rsob.180002

PMid:29769323 PMCid:PMC5990650

7. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2002;2:442-54.

https://doi.org/10.1038/nrc822

PMid:12189386 

8. Berx G, van Roy F. Involvement of members of the cadherin superfamily in cancer. Cold Spring Harb Perspect Biol. 2009;1:a003129.

https://doi.org/10.1101/cshperspect.a003129

PMid:20457567 PMCid:PMC2882122

9. Kar D, Banerjee S. Epithelial expression of epithelia-cadherin in different grades of oral squamous cell carcinoma. J Oral Maxillofac Pathol. 2021;25:253-57.

PMid:34703118

10. Galíndez MF, Carrica A, Zarate AM, Secchi D, Don J, Barra JL, et al. DNA repair, NFKβ, and TP53 polymorphisms associated with potentially malignant disorders and oral squamous cell carcinoma in Argentine patients. Oral Surg Oral Med Oral Pathol Oral Radiol. 2021;131:339-46.

https://doi.org/10.1016/j.oooo.2020.11.004

PMid:33309268 

11. Luisi P, García A, Berros JM, Motti JMB, Demarchi DA, Alfaro E, et al. Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina. PLoS One. 2020;15: e0233808.

https://doi.org/10.1371/journal.pone.0233808

PMid:32673320 PMCid:PMC7365470

12. James CC, Zeitz MJ, Calhoun PJ, Lamouille S, Smyth JW. Altered translation initiation of Gja1 limits gap junction formation during epithelial-mesenchymal transition. Mol Biol Cell. 2018;29:797-808.

https://doi.org/10.1091/mbc.E17-06-0406

PMid:29467255 PMCid:PMC5905293

13. De Aquino SN, Messetti AC, Bagordakis E, Martelli-Júnior H, Swerts MS, Graner E, et al. Polymorphisms in FGF12, VCL, CX43 and VAX1 in Brazilian patients with nonsyndromic cleft lip with or without cleft palate. BMC Med Genet. 2013;14:53.

https://doi.org/10.1186/1471-2350-14-53

PMid:23679094 PMCid:PMC3660181

14. González Segura I, Secchi D, Carrica A, Barello R, Arbelo D, Burgos A, et al. Exfoliative cytology as a tool for monitoring pre-malignant and malignant lesions based on combined stains and morphometry techniques. J Oral Pathol Med. 2015;44:178-84.

https://doi.org/10.1111/jop.12219

PMid:25065639 

15. Centeno VA, Fontanetti PA, Interlandi V, Ponce RH, Gallará RV. Fluoride alters connexin expression in rat incisor pulp. Arch Oral Biol. 2015;60:313-19.

https://doi.org/10.1016/j.archoralbio.2014.11.003

PMid:25438100 

16. Tanaka T, Kimura M, Ishiguro H, Mizoguchi K, Takeyama H. Connexin 43 expression is associated with poor survival in patients with esophageal squamous cell carcinoma. Mol Clin Oncol. 2016;4:989-93.

https://doi.org/10.3892/mco.2016.828

PMid:27284434 PMCid:PMC4887812

17. Scherma ME, Madzzuduli G, Silva RA, Garay MI, Repossi G, Brunotto M, et al. The effects of ω-6 and ω-3 fatty-acids on early stages of mice DMBA submandibular glands tumorigenesis. Prostaglandins Leukot Essent Fatty Acids. 2017;125:48-55.

https://doi.org/10.1016/j.plefa.2017.08.004

PMid:28987722 

18. Brockmeyer P, Hemmerlein B, Jung K, Fialka F, Brodmann T, Gruber RM, et al. Connexin subtype expression during oral carcinogenesis: A pilot study in patients with oral squamous cell carcinoma. Mol Clin Oncol. 2016;4:298-302.

https://doi.org/10.3892/mco.2015.685

PMid:26893879 PMCid:PMC4734076

19. Fostok S, El-Sibai M, Bazzoun D, Lelièvre S, Talhouk R. Connexin 43 loss triggers cell cycle entry and invasion in non-neoplastic breast epithelium: a role for noncanonical wnt signaling. Cancers. 2019;11: 339.

https://doi.org/10.3390/cancers11030339

PMid:30857262 PMCid:PMC6468895

20. López-Verdín S, Martínez-Fierro ML, Garza-Veloz I, Zamora-Perez A, Grajeda-Cruz J, González-González R, et al. E-Cadherin gene expression in oral cancer: Clinical and prospective data. Med Oral Patol Oral Cir Bucal. 2019;24:e444-51.

https://doi.org/10.4317/medoral.23029

PMid:31256188 PMCid:PMC6667017

21. Maria de França G, Andrade ACM, Felix FA, da Silva WR, Almeida DRMF, Leite RB, et al. Survival-related epithelial-mesenchymal transition proteins in oropharyngeal squamous cell carcinoma: A systematic review and meta-analysis. Arch Oral Biol. 2021;131:105267.

https://doi.org/10.1016/j.archoralbio.2021.105267

PMid:34592489 

22. Wincewicz A, Baltaziak M, Kanczuga-Koda L, Lesniewicz T, Rutkowski R, Sobaniec-Lotowska M, et al. Aberrant distributions and relationships among E-cadherin, beta-catenin, and connexin 26 and 43 in endometrioid adenocarcinomas. Int J Gynecol Pathol. 2010;29:358-65.

https://doi.org/10.1097/PGP.0b013e3181c3c57f

PMid:20567150 

23. Juneja S, Chaitanya NB, Agarwal M. Immunohistochemical expression of Bcl-2 in oral epithelial dysplasia and oral squamous cell carcinoma. Indian J Cancer. 2015;52:505-10.

https://doi.org/10.4103/0019-509X.178411

PMid:26960459 

24. Coutinho-Camillo CM, Lourenço SV, Nishimoto IN, Kowalski LP, Soares FA. Expression of Bcl-2 family proteins and association with clinicopathological characteristics of oral squamous cell carcinoma. Histopathology. 2010;57:304-16.

https://doi.org/10.1111/j.1365-2559.2010.03621.x

PMid:20716171 

25. Zhang M, Zhang P, Zhang C, Sun J, Wang L, Li J, et al. Prognostic significance of Bcl-2 and Bax protein expression in the patients with oral squamous cell carcinoma. J Oral Pathol Med. 2009;38:307-13.

https://doi.org/10.1111/j.1600-0714.2008.00689.x

PMid:18710422 

26. Camisasca DR, Honorato J, Bernardo V, da Silva LE, da Fonseca EC, de Faria PA, et al. Expression of Bcl-2 family proteins and associated clinicopathologic factors predict survival outcome in patients with oral squamous cell carcinoma. Oral Oncol. 2009;45:225-33.

https://doi.org/10.1016/j.oraloncology.2008.05.021

PMid:18715811 

27. Bose P, Klimowicz AC, Kornaga E, Petrillo SK, Matthews TW, Chandarana S, et al. Bax expression measured by AQUAnalysis is an independent prognostic marker in oral squamous cell carcinoma. BMC Cancer. 2012;12:332.

https://doi.org/10.1186/1471-2407-12-332

PMid:22852863 PMCid:PMC3487960

28. Gilligan GM, Panico RL, Di Tada C, Piemonte ED, Brunotto MN. Clinical and Immunohistochemical epithelial profile of non-healing chronic traumatic ulcers. Med Oral Patol Oral Cir Bucal. 2020;25: e706-13.

https://doi.org/10.4317/medoral.23729

PMid:32683386 PMCid:PMC7473441

29. Talbot J, Dupuy M, Morice S, Rédini F, Verrecchia F. Antagonistic Functions of Connexin 43 during the Development of Primary or Secondary Bone Tumors. Biomolecules. 2020;10:1240.

https://doi.org/10.3390/biom10091240

PMid:32859065 PMCid:PMC7565206

30. Austin H, Flanders WD, Rothman KJ. Bias arising in case-control studies from selection of controls from overlapping groups. Int J Epidemiol.1989;18:713-6.

https://doi.org/10.1093/ije/18.3.713

PMid:2807679