Al-Jamaei AA, Subramanyam RV, Helder MN, Forouzanfar T, Ruslin M, Meij EV, et al. Significance of immunohistochemistry biomarkers in prediction of malignant transformation of oral lichen planus: A systematic review. Med Oral Patol Oral Cir Bucal. 2022 Sep 1;27 (5):e480-8.
doi:10.4317/medoral.25491
https://dx.doi.org/doi:10.4317/medoral.25491
1. Gupta S, Jawanda MK. Oral Lichen Planus: An Update on Etiology, Pathogenesis, Clinical Presentation, Diagnosis and Management. Indian J Dermatol. 2015;60:222-9. |
PMid:26120146 PMCid:PMC4458931 |
2. Gonzalez-Moles MA, Warnakulasuriya S, Gonzalez-Ruiz I, Gonzalez-Ruiz L, Ayen A, Lenouvel D, et al. Worldwide prevalence of oral lichen planus: A systematic review and meta-analysis. Oral Dis. 2021;27:813-28. |
PMid:32144836 |
3. Eisen D. The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients. J Am Acad Dermatol. 2002;46:207-14. |
PMid:11807431 |
4. Lodi G, Manfredi M, Mercadante V, Murphy R, Carrozzo M. Interventions for treating oral lichen planus: corticosteroid therapies. Cochrane Database Syst Rev. 2020;2:CD001168. |
PMid:32108333 |
5. Idrees M, Kujan O, Shearston K, Farah CS. Oral lichen planus has a very low malignant transformation rate: A systematic review and meta-analysis using strict diagnostic and inclusion criteria. J Oral Pathol Med. 2021;50:287-98. |
PMid:31981238 |
6. Warnakulasuriya S, Lodi G. Oral potentially malignant disorders: Proceedings from an expert symposium. Oral Dis. 2021;27:1859-61. |
PMid:34379867 |
7. Gonzalez-Moles MA, Warnakulasuriya S, Gonzalez-Ruiz I, Ayen A, Gonzalez-Ruiz L, Ruiz-Avila I, et al. Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper. Med Oral Patol Oral Cir Bucal. 2021;26:e541-e8. |
PMid:34162824 PMCid:PMC8254877 |
8. van der Meij EH, Schepman KP, Plonait DR, Axell T, van der Waal I. Interobserver and intraobserver variability in the clinical assessment of oral lichen planus. J Oral Pathol Med. 2002;31:95-8. |
PMid:11896830 |
9. Matos LL, Trufelli DC, de Matos MG, da Silva Pinhal MA. Immunohistochemistry as an important tool in biomarkers detection and clinical practice. Biomark Insights. 2010;5:9-20. |
PMid:20212918 PMCid:PMC2832341 |
10. Teunissen CE, Malekzadeh A, Leurs C, Bridel C, Killestein J. Body fluid biomarkers for multiple sclerosis--the long road to clinical application. Nat Rev Neurol. 2015;11:585-96. |
PMid:26392381 |
11. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700. |
PMid:19622552 PMCid:PMC2714672 |
12. Booth A, Clarke M, Dooley G, Ghersi D, Moher D, Petticrew M, et al. The nuts and bolts of PROSPERO: an international prospective register of systematic reviews. Syst Rev. 2012;1:2. |
PMid:22587842 PMCid:PMC3348673 |
13. Altman DG, McShane LM, Sauerbrei W, Taube SE. Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): explanation and elaboration. PLoS Med. 2012;9:e1001216. |
PMid:22675273 PMCid:PMC3362085 |
14. Mattila R, Alanen K, Syrjanen S. Desmocollin expression in oral atrophic lichen planus correlates with clinical behavior and DNA content. J Cutan Pathol. 2008;35:832-8. |
PMid:18422976 |
15. Schifter M, Jones AM, Walker DM. Epithelial p53 gene expression and mutational analysis, combined with growth fraction assessment, in oral lichen planus. J Oral Pathol Med. 1998;27:318-24. |
PMid:9725569 |
16. Valente G, Pagano M, Carrozzo M, Carbone M, Bobba V, Palestro G, et al. Sequential immunohistochemical p53 expression in biopsies of oral lichen planus undergoing malignant evolution. J Oral Pathol Med. 2001;30:135-40. |
PMid:11271627 |
17. Ogmundsdottir HM, Hilmarsdottir H, Astvaldsdottir A, Johannsson JH, Holbrook WP. Oral lichen planus has a high rate of TP53 mutations. A study of oral mucosa in icelanD. Eur J Oral Sci. 2002;110:192-8. |
PMid:12120703 |
18. Lee JJ, Kuo MY, Cheng SJ, Chiang CP, Jeng JH, Chang HH, et al. Higher expressions of p53 and proliferating cell nuclear antigen (PCNA) in atrophic oral lichen planus and patients with areca quid chewing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:471-8. |
PMid:15772596 |
19. de Sousa FA, Paradella TC, Carvalho YR, Rosa LE. Comparative analysis of the expression of proliferating cell nuclear antigen, p53, bax, and bcl-2 in oral lichen planus and oral squamous cell carcinoma. Ann Diagn Pathol. 2009;13:308-12. |
PMid:19751907 |
20. Safadi RA, Al Jaber SZ, Hammad HM, Hamasha AA. Oral lichen planus shows higher expressions of tumor suppressor gene products of p53 and p21 compared to oral mucositis. An immunohistochemical study. Arch Oral Biol. 2010;55:454-61. |
PMid:20427035 |
21. Leyva-Huerta ER, Ledesma-Montes C, Rojo-Botello RE, Vega-Memije E. P53 and bcl-2 immunoexpression in patients with oral lichen planus and oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 2012;17:e745-50. |
PMid:22549684 PMCid:PMC3482516 |
22. Oliveira Alves M, Balducci I, Rodarte Carvalho Y, Cabral L, Nunes F, Almeida J. Evaluation of the expression of p53, MDM2, and SUMO-1 in oral lichen planus. Oral Dis. 2013;19:775-80. |
PMid:23350884 |
23. Sanketh DS, Kumari K, Rao RS, Haragannavar VC, Sarode SC, Sarode GS, et al. Expression of Ki-67, p53, alpha-SMA and COX-2 in lichen planus and related lesions: A pilot study. J Oral Biol Craniofac Res. 2019;9:230-5. |
PMid:31211042 PMCid:PMC6562184 |
24. Shailaja G, Kumar JV, Baghirath PV, Kumar U, Ashalata G, Krishna AB. Estimation of malignant transformation rate in cases of oral epithelial dysplasia and lichen planus using immunohistochemical expression of Ki-67, p53, BCL-2, and BAX markers. Dent Res J (Isfahan). 2015;12:235-42. |
PMid:26005463 |
25. Hadzi-Mihailovic M, Cakic S, Jankovic S, Raybaud H, Nedeljkovic N, Jankovic L. Ki-67 expression in oral lichen planus. J BUON. 2012;17:132-7. |
PMid:22517707 |
26. Rosa EA, Hurtado-Puerto AM, Falcao DP, Brietzke AP, De Almeida Prado Franceschi LE, Cavalcanti Neto FF, et al. Oral lichen planus and malignant transformation: The role of p16, Ki-67, Bub-3 and SOX4 in assessing precancerous potential. Exp Ther Med. 2018;15:4157-66. |
PMid:29731815 PMCid:PMC5920964 |
27. Zargaran M, Jamshidi S, Eshghyar N, Moghimbeigi A. Suitability/unsuitability of cell proliferation as an indicator of malignant potential in oral lichen planus: an immunohistochemical study. Asian Pac J Cancer Prev. 2013;14:6979-83. |
PMid:24377636 |
28. Hadzi-Mihailovic M, Raybaud H, Monteil R, Cakic S, Djuric M, Jankovic L. Bcl-2 expression and its possible influence on malignant transformation of oral lichen planus. J BUON. 2010;15:362-8. |
PMid:20658736 |
29. Nafarzadeh S, Jafari S, Bijani A. Assessment of bax and bcl-2 immunoexpression in patients with oral lichen planus and oral squamous cell carcinoma. Int J Mol Cell Med. 2013;2:136-42. |
PMid:24551804 |
30. Goel S, Khurana N, Marwah A, Gupta S. Expression of cdk4 and p16 in Oral Lichen Planus. J Oral Maxillofac Res. 2015;6:e4. |
PMid:26229583 PMCid:PMC4516856 |
31. Salehinejad J, Sharifi N, Amirchaghmaghi M, Ghazi N, Shakeri MT, Ghazi A. Immunohistochemical expression of p16 protein in oral squamous cell carcinoma and lichen planus. Ann Diagn Pathol. 2014;18:210-3 |
PMid:24850170 |
32. Liu T, Zhang H, Yang X, Li X, Shi Y, Niu W, et al. Study on expression of p16 and human papillomavirus 16 and 18 (E6) in OLP and its malignant transformation. Pathol Res Pract. 2018;214:296-302. |
PMid:29254790 |
33. Hadzi-Mihailovic M, Stanimirovic D, Pasoski B. Role of tumor suppressor protein p16 in patients with oral lichen planus. J BUON. 2020;25:1193-8. |
PMid:32521925 |
34. Neppelberg E, Johannessen AC. DNA content, Cyclooxygenase-2 expression and loss of E-cadherin expression do not predict risk of malignant transformation in oral lichen planus. Eur Arch Otorhinolaryngol. 2007;264:1223-30. |
PMid:17530268 |
35. Baghaei F, Shojaei S, Afshar-Moghaddam N, Zargaran M, Rastin V, Nasr M, et al. Study of P21 Expression in Oral Lichen Planus and Oral Squamous Cell Carcinoma by Immunohistochemical Technique. J Dent (Shiraz). 2015;16:156-61. |
PMid:26331143 |
36. Oluwadara O, Giacomelli L, Christensen R, Kossan G, Avezova R, Chiappelli F. LCK, survivin and PI-3K in the molecular biomarker profiling of oral lichen planus and oral squamous cell carcinoma. Bioinformation. 2009;4:249-57. |
PMid:20975919 PMCid:PMC2951717 |
37. Suganya G, Bavle RM, Paremala K, Makarla S, Sudhakar M, Reshma V. Survivin expression in oral lichen planus: Role in malignant transformation. J Oral Maxillofac Pathol. 2016;20:234-8. |
PMid:27601815 PMCid:PMC4989553 |
38. Speight PM, Takata T. New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumours. Virchows Arch. 2018;472:331-9. |
PMid:28674741 PMCid:PMC5886999 |
39. Abbas T, Dutta A. p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer. 2009;9:400-14. |
PMid:19440234 PMCid:PMC2722839 |
40. McCormick D, Hall PA. The complexities of proliferating cell nuclear antigen. Histopathology. 1992;21:591-4. |
PMid:1361482 |
41. Roninson IB. Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts. Cancer Lett. 2002;179:1-14. |
PMid:11880176 |
42. Huang WY, Coltrera M, Schubert M, Morton T, Truelove E. Histopathologic evaluation of proliferating cell nuclear antigen (PC10) in oral epithelial hyperplasias and premalignant lesions. Oral Surg Oral Med Oral Pathol. 1994;78:748-54. |
PMid:7534896 |
43. Poosarla C, Ramesh M, Ramesh K, Gudiseva S, Bala S, Sundar M. Proliferating Cell Nuclear Antigen in Premalignancy and Oral Squamous Cell Carcinoma. J Clin Diagn Res. 2015;9:ZC39-41. |
PMid:26266215 PMCid:PMC4525605 |
44. Tsushima F, Sakurai J, Uesugi A, Oikawa Y, Ohsako T, Mochizuki Y, et al. Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients. BMC Oral Health. 2021;21:298. |
PMid:34112142 PMCid:PMC8194014 |
45. el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, et al. WAF1, a potential mediator of p53 tumor suppression. Cell. 1993;75:817-25. |
PMid:8242752 |
46. Yanamoto S, Kawasaki G, Yoshitomi I, Mizuno A. p53, mdm2, and p21 expression in oral squamous cell carcinomas: relationship with clinicopathologic factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94:593-600. |
PMid:12424454 |
47. Gonzalez-Moles MA, Bascones-Ilundain C, Gil Montoya JA, Ruiz-Avila I, Delgado-Rodriguez M, Bascones-Martinez A. Cell cycle regulating mechanisms in oral lichen planus: molecular bases in epithelium predisposed to malignant transformation. Arch Oral Biol. 2006;51:1093-103. |
PMid:16914114 |
48. Wang L, Han H, Dong L, Wang Z, Qin Y. Function of p21 and its therapeutic effects in esophageal cancer. Oncol Lett. 2021;21:136. |
PMid:33552255 PMCid:PMC7798030 |
49. Monteiro L, Mello FW, Warnakulasuriya S. Tissue biomarkers for predicting the risk of oral cancer in patients diagnosed with oral leukoplakia: A systematic review. Oral Dis. 2021;27:1977-92. |
PMid:33290585 |
50. Soussi T, Beroud C. Assessing TP53 status in human tumours to evaluate clinical outcome. Nat Rev Cancer. 2001;1:233-40. |
PMid:11902578 |
51. Graveland AP, Bremmer JF, de Maaker M, Brink A, Cobussen P, Zwart M, et al. Molecular screening of oral precancer. Oral Oncol. 2013;49:1129-35. |
PMid:24120275 |
52. Brennan JA, Boyle JO, Koch WM, Goodman SN, Hruban RH, Eby YJ, et al. Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck. N Engl J Med. 1995;332:712-7. |
PMid:7854378 |
53. Kuttan NA, Rosin MP, Ambika K, Priddy RW, Bhakthan NM, Zhang L. High prevalence of expression of p53 oncoprotein in oral carcinomas from India associated with betel and tobacco chewing. Eur J Cancer B Oral Oncol. 1995;31B:169-73. |
PMid:7549756 |
54. Kilpi A, Rich AM, Konttinen YT, Reade PC. Expression of c-erbB-2 protein in keratinocytes of oral mucosal lichen planus and subsequent squamous cell carcinoma. Eur J Oral Sci. 1996;104:278-84. |
PMid:8831062 |
55. Saluja TS, Ali M, Mishra P, Kumar V, Singh SK. Prognostic Value of Cancer Stem Cell Markers in Potentially Malignant Disorders of Oral Mucosa: A Meta-analysis. Cancer Epidemiol Biomarkers Prev. 2019;28:144-53 |
PMid:30315141 |