1. Shao Y, Zhou H. Clinical evaluation of an oral mucoadhesive film containingchitosan for the treatment of recurrent aphthous stomatitis: a randomized, double-blind study. J Dermatolog Treat. 2020;31:739-43.

https://doi.org/10.1080/09546634.2019.1610548

PMid:31179773 

2. El-Wakeel NM, Dawoud MHS. Topical insulin-liposomal formulation inmanagement of recurrent aphthous ulcers: A randomized placebo-controlled trial. J Investig Clin Dent. 2019;10:e12437.

https://doi.org/10.1111/jicd.12437

PMid:31350870 

3. Nosratzehi T, Akar A. Efficacy of Omega-3 in Treatment of Recurrent Aphthous Stomatitis: A Randomised, Double-blind, Placebo-controlled Study. Chin J Dent Res. 2016;19:159-64.

PMid:27622219

4. Rodríguez-Archilla A, Raissouni T. Randomized clinical trial of the effectiveness of complementary therapies for recurrent aphthous stomatitis. Med Clin (Barc). 2017;149:55-60.

https://doi.org/10.1016/j.medcle.2017.06.014

PMid:28238332

5. Bardellini E, Veneri F, Amadori F, Conti G, Majorana A. Photobiomodulationtherapy for the management of recurrent aphthous stomatitis in children: clinical effectiveness and parental satisfaction. Med Oral Patol Oral Cir Bucal. 2020;25:e549-53.

https://doi.org/10.4317/medoral.23573

PMid:32388522 PMCid:PMC7338059

6. Giammarinaro E, Cosola S, Oldoini G, Gulia F, Peñarrocha-Oltra D, Marconcini S, et al. Local Formula with Mucoadhesive Property: A Randomized Clinical Trial of a Therapeutic Agent for the Treatment of Oral Aphthous Ulcers. J Contemp Dent Pract. 2019;20:1249-53.

https://doi.org/10.5005/jp-journals-10024-2709

PMid:31892674 

7. Giannetti L, Murri Dello Diago A, Lo Muzio L. Recurrent aphtous stomatitis. Minerva Stomatol. 2018;67:125-8.

https://doi.org/10.23736/S0026-4970.18.04137-7

PMid:29332375 

8. Habibzadeh S, Sheikh Rahimi M, Edalatkhah H, Piri H, Maleki N. Effectiveness of booster dose of tetanus and diphtheria toxoids (Td) vaccine in management of recurrent aphthous stomatitis: a prospective, randomized, triple-blind and placebo-controlled clinical trial. J Dermatolog Treat. 2021;32:361-6.

https://doi.org/10.1080/09546634.2019.1654597

PMid:31403361 

9. Zhu S, Shi Q, Lu J. Curative effect of oral ulcer powder on the treatment of recurrent aphthous ulcer. Pak J Pharm Sci. 2018;31:1175-8.

PMid:29735470

10. Arafa MG, Ghalwash D, El-Kersh DM, Elmazar MM. Propolis-based niosomes as oromuco-adhesive films: A randomized clinical trial of a therapeutic drug delivery platform for the treatment of oral recurrent aphthous ulcers. Sci Rep. 2018;8:18056.

https://doi.org/10.1038/s41598-018-37157-7

PMid:30575794 PMCid:PMC6303391

11. Vaziri S, Mojarrab M, Farzaei MH, Najafi F, Ghobadi A. Evaluation of anti- aphthous activity of decoction of Nicotiana tabacum leaves as a mouthwash: a placebo-controlled clinical study. J Tradit Chin Med. 2016;36:160-4.

https://doi.org/10.1016/S0254-6272(16)30022-X

PMid:27400469

12. Guo Q, Yang J, Yu M. Observing the effect of traditional Chinese medicine Kouchuang Xiaotong powder on patients with recurrent aphthus ulcer. Pak J Pharm Sci. 2018;31:1687-90.

PMid:30203763

13. Ofluoglu D, Ergun S, Warnakulasuriya S, Namdar-Pekiner F, Tanyeri H. An evaluation of the efficacy of a topical gel with Triester Glycerol Oxide (TGO) in the treatment of minor recurrent aphthous stomatitis in a Turkish cohort: Arandomized, double-blind, placebo-controlled clinical trial. Med Oral Patol Oral Cir Bucal. 2017;22:e159-66.

https://doi.org/10.4317/medoral.21469

PMid:28160585 PMCid:PMC5359701

14. Yarom N, Zelig K, Epstein JB, Gorsky M. The efficacy of minocycline mouth rinses on the symptoms associated with recurrent aphthous stomatitis: a randomized, double-blind, crossover study assessing different doses of oral rinse. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123:675-9.

https://doi.org/10.1016/j.oooo.2017.02.013

PMid:28411006 

15. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097.

https://doi.org/10.1371/journal.pmed.1000097

PMid:19621072 PMCid:PMC2707599

16. Balshem H, Helfand M, Schünemann HJ, Oxman AD, Kunz R, Brozek J, et al. GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011;64:401-6.

https://doi.org/10.1016/j.jclinepi.2010.07.015

PMid:21208779 

17. Pedersen AML, Bukkehave KH, Bennett EP, Twetman S. Effect of Lozenges Containing Lactobacillus reuteri on the Severity of Recurrent Aphthous Ulcers: a Pilot Study. Probiotics Antimicrob Proteins. 2020;12:819-23.

https://doi.org/10.1007/s12602-019-09586-x

PMid:31410765 

18. Aggour RL, Mahmoud SH, Abdelwhab A. Evaluation of the effect of probiotic lozenges in the treatment of recurrent aphthous stomatitis: a randomized, controlled clinical trial. Clin Oral Investig. 2021;25:2151-8.

https://doi.org/10.1007/s00784-020-03527-7

PMid:32820431 

19. Bardellini E, Amadori F, Conti G, Majorana A. Clinical efficacy of a solution composed by sodium bicarbonate and alginate, aloe vera, propoli, chamomile, calendula and honey, in the treatment of minor recurrent aphthous stomatitis in children. Minerva Pediatr. 2016;68:507-9.

PMid:27768020

20. Sakly A, De Wever B, Jutla B, Satia M, Bogaert JP. The safety and efficacy of AphtoFix® mouth ulcer cream in the management of recurrent aphthous stomatitis. BMC Oral Health. 2016;16:17.

https://doi.org/10.1186/s12903-016-0177-0

PMid:26868504 PMCid:PMC4750241

21. Yilmaz HG, Albaba MR, Caygur A, Cengiz E, Boke-Karacaoglu F, Tumer H. Treatment of recurrent aphthous stomatitis with Er,Cr:YSGG laser irradiation: A randomized controlled split mouth clinical study. J Photochem Photobiol B. 2017;170:1-5.

https://doi.org/10.1016/j.jphotobiol.2017.03.011

PMid:28359996 

22. Ibrahim SA, Elkot RA, Soliman HE. Lactic acid 5% mouth wash vs Kenalog in Orabase 0.1% for treatment and prophylaxis of recurrent aphthous ulcer. J Cosmet Dermatol. 2020;19:964-9.

https://doi.org/10.1111/jocd.13110

PMid:31436378 

23. Akbari N, Asadimehr N, Kiani Z. The effects of licorice containing diphenhydramine solution on recurrent aphthous stomatitis: A double-blind, randomized clinical trial. Complement Ther Med. 2020;50:102401.

https://doi.org/10.1016/j.ctim.2020.102401

PMid:32444056 

24. Huo X, Han N, Liu L. Effect of different treatments on recurrent aphthous stomatitis: laser versus medication. Lasers Med Sci. 2021;36:1095-100.

https://doi.org/10.1007/s10103-020-03166-0

PMid:33140267 

25. Raman P, Pitty R, Krithika CL, Anand SPN, Subramani GP. Topical Curcumin and Triamcinolone Acetonide in Recurrent Minor Aphthous Ulcers: A Pilot Trial. J Contemp Dent Pract. 2020;21:884-90.

https://doi.org/10.5005/jp-journals-10024-2901

PMid:33568610 

26. Zeng Q, Shi X, Yang J, Yang M, Zhao W, Zhao X, et al. The efficacy and safety of thalidomide on the recurrence interval of continuous recurrent aphthous ulceration: A randomized controlled clinical trial. J Oral Pathol Med. 2020;49:357-64.

https://doi.org/10.1111/jop.12960

PMid:31514233 

27. Sánchez-Bernal J, Conejero C, Conejero R. Recurrent Aphthous Stomatitis. Actas Dermosifiliogr. 2020;111:471-80.

https://doi.org/10.1016/j.ad.2019.09.004

PMid:32451064