Machado RA, Oliveira LQ, Martelli-Júnior H, Pires FR, Carvas JB, Rogerio VE, et al. Adverse reactions to the injection of face and neck aesthetic filling materials: a systematic review. Med Oral Patol Oral Cir Bucal. 2023 May 1;28 (3):e278-84.


doi:10.4317/medoral.25713

https://dx.doi.org/doi:10.4317/medoral.25713


1. Christensen LH. Host tissue interaction, fate, and risks of degradable and nondegradable gel fillers. Dermatol Surg. 2009;35:1612-9.

https://doi.org/10.1111/j.1524-4725.2009.01338.x

PMid:19807755 

2. Ahn CS, Rao BK. The life cycles and biological end pathways of dermal fillers. J Cosmet Dermatol. 2014;13:212-23.

https://doi.org/10.1111/jocd.12100

PMid:25196689 

3. Moragas JSM, Reddy RR, Alfaro FH, Mommaerts MY. Systematic review of "filling" procedures for lip augmentation regarding types of material, outcomes and complications. J Cranio-Maxillofac Surg. 2015;43:883-906.

https://doi.org/10.1016/j.jcms.2015.03.032

PMid:25957105 

4. Signorini M, Liew S, Sundaram H, De Boulle KL, Goodman GJ, Monheit G, et al. Global Aesthetics Consensus: Avoidance and Management of Complications from Hyaluronic Acid Fillers-Evidence- and Opinion-Based Review and Consensus Recommendations. Plast Reconstr Surg. 2016;137:961e-71e.

https://doi.org/10.1097/PRS.0000000000002184

PMid:27219265 PMCid:PMC5242216

5. Wang LL, Thomas WW, Friedman O. Granuloma formation secondary to silicone injection for soft-tissue augmentation in facial cosmetics: Mechanisms and literature review. Ear Nose Throat J. 2018;97:e46-e51.

https://doi.org/10.1177/0145561318097001-211

PMid:29493732 

6. Chung KL, Convery C, Ejikeme I, Ghanem AM. A Systematic Review of the Literature of Delayed Inflammatory Reactions After Hyaluronic Acid Filler Injection to Estimate the Incidence of Delayed Type Hypersensitivity Reaction. Aesthet Surg J. 2020;40:NP286-NP300.

https://doi.org/10.1093/asj/sjz222

PMid:31410442 

7. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097.

https://doi.org/10.1371/journal.pmed.1000097

PMid:19621072 PMCid:PMC2707599

8. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann T, Mulrow C, et al. Mapping of reporting guidance for systematic reviews and meta-analyses generated a comprehensive item bank for future reporting guidelines. J Clin Epidemiol. 2020;118:60-8.

https://doi.org/10.1016/j.jclinepi.2019.11.010

PMid:31740319 

9. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016;5:210.

https://doi.org/10.1186/s13643-016-0384-4

PMid:27919275 PMCid:PMC5139140

10. Munn Z, Moola S, Lisy K, Riitano D, Tufanaru C. Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and incidence data. Int J Evid Based Healthc. 2015;13:147-53.

https://doi.org/10.1097/XEB.0000000000000054

PMid:26317388 

11. Haneke E. Adverse effects of fillers and their histopathology. Facial Plast Surg. 2014;30:599-614.

https://doi.org/10.1055/s-0034-1396755

PMid:25536126 

12. Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox) and nonanimal sourced hyaluronic acid (NASHA, Restylane) in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A. Dermatol Surg. 2003;29:802-9.

https://doi.org/10.1097/00042728-200308000-00004

PMid:12859378 

13. Shaha KK, Pritta BS, Alexander MP. Histopathologic review of granulomatous inflammation. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases. 2017;7:1-12.

https://doi.org/10.1016/j.jctube.2017.02.001

PMid:31723695 PMCid:PMC6850266

14. Rongioletti F, Atzori L, Ferreli C, Pau M, Pinna AL, Mercuri SR, et al. Granulomatous reactions after injections of multiple aesthetic micro-implants in temporal combinations: a complication of filler addiction. Journal of the European Academy of Dermatology and Venereology: JEADV. 2015;29:1188-92.

https://doi.org/10.1111/jdv.12788

PMid:25351609 

15. Liu A, Kollipara R, Hoss E, Goldman MP. Lower eyelid xanthelasma following hyaluronic acid filler injections to the tear troughs. Journal of cosmetic dermatology. 2021;20:3190-2.

https://doi.org/10.1111/jocd.14166

PMid:33877741 

16. Pires VS, Wender IO, Santos MF, Sartori GL, Vivian A, Dallagnese G. Xanthelasma palpebrarum after hyaluronic acid injection in the lower eyelid: A case report and review of the literature. Journal of cosmetic dermatology. 2021;20:2750-2.

https://doi.org/10.1111/jocd.13930

PMid:33387399 

17. Or L, Eviatar JA, Massry GG, Bernardini FP, Hartstein ME. Xanthelasma-Like Reaction to Filler Injection. Ophthalmic plastic and reconstructive surgery. 2017;33:244-7.

https://doi.org/10.1097/IOP.0000000000000722

PMid:27218809 

18. Depot MJ, Jakobiec FA, Dodick JM, Iwamoto T. Bilateral and extensive xanthelasma palpebrarum in a young man. Ophthalmology. 1984;91:522-7.

https://doi.org/10.1016/S0161-6420(84)34260-9

PMid:6739054

19. Youn SJ, Park HS, Kim WS, Lee ES, Yang JM. Bilateral xanthelasma palpebrarum on both eyelids in a 9-year-old boy. Pediatr Dermatol. 2006;23:95-7.

https://doi.org/10.1111/j.1525-1470.2006.00183.x

PMid:16445426 

20. Seike M, Ikeda M, Matsumoto M, Hamada R, Takeya M, Kodama H. Hyaluronan forms complexes with low density lipoprotein while also inducing foam cell infiltration in the dermis. J Dermatol Sci. 2006;41:197204.

https://doi.org/10.1016/j.jdermsci.2005.10.008

PMid:16356687 

21. Jakobiec FA, Rai R, Rashid A, Sutula FC. Bilateral eyelid pseudoptosis from lipogranulomas of the preaponeurotic fat pads. Ophthal Plast Reconstr Surg. 2015;31:e125-31.

https://doi.org/10.1097/IOP.0000000000000157

PMid:24841730 

22. Jakobiec FA, Ma L, Wolkow N, Sutula FC, Freitag SK. The Significance of Extracellular Cholesterol Crystals or a Cholesterol Granuloma in Xanthelasma. Ocul Oncol Pathol. 2018;4:345-54.

https://doi.org/10.1159/000486532

PMid:30574485 PMCid:PMC6288668

23. Sa HS, Woo KI, Suh YL, Kim YD. Periorbital lipogranuloma: a previously unknown complication of autologous fat injections for facial augmentation. The British journal of ophthalmology. 2011;95:1259-63.

https://doi.org/10.1136/bjo.2010.180547

PMid:21041459 

24. Eun YS, Cho SH, Lee JD, Kim HS. A woman with a nose like an "Elephant's Trunk". Journal of cosmetic and laser therapy: official publication of the European Society for Laser Dermatology. 2014;16:153-4.

https://doi.org/10.3109/14764172.2013.864200

PMid:24245997 

25. Lowe NJ, Maxwell CA, Lowe P, Duick MG, Shah K. Hyaluronic acid skin fillers: adverse reactions and skin testing. J Am Acad Dermatol. 2001;45:930-3

https://doi.org/10.1067/mjd.2001.117381

PMid:11712042 

26. Edwards PC, Fantasia JE. Review of long-term adverse effects associated with the use of chemically-modified animal and nonanimal source hyaluronic acid dermal fillers. Clin Interv Aging. 2007;2:509-19.

https://doi.org/10.2147/CIA.S382

PMid:18225451 PMCid:PMC2686337

27. Fitzgerald R, Bertucci V, Sykes JM, Duplechain JK. Adverse Reactions to Injectable Fillers. Facial Plast Surg. 2016;32:532-55.

https://doi.org/10.1055/s-0036-1592340

PMid:27680525 

28. Marcoval J, Mañá J, Penín RM, Figueras I, Labori M, Llatjos R. Sarcoidosis associated with cosmetic fillers. Clin Exp Dermatol. 2014;39:397-9.

https://doi.org/10.1111/ced.12262

PMid:24450767 

29. Ortiz-Álvarez J, Lebrón-Martín JÁ, Fernández-Freire LR, Dorado TZ, García Morillo JS. Cutaneous and ganglion sarcoidosis induced by polycaprolactone facial filler: A new expression of ASIA syndrome? Eur J Case Rep Intern Med. 2021;8:6.

https://doi.org/10.12890/2021_002652

PMid:34268272 PMCid:PMC8276932

30. Brongo S, Moccia LS, Nunziata V, D'Andrea F. Keratoacanthoma arising after site injection infection of cosmetic collagen filler. International journal of surgery case reports. 2013;4:429-31.

https://doi.org/10.1016/j.ijscr.2013.01.012

PMid:23500750 PMCid:PMC3605485

31. Gewirtzman A, Meirson DH, Rabinovitz H. Eruptive keratoacanthoma following carbon dioxide laser resurfacing. Dermatol Surg. 1999;25:666-8.

https://doi.org/10.1046/j.1524-4725.1999.99072.x

PMid:10491052 

32. Cox S. Rapid development of keratoacanthomas after a body peel. Dermatol Surg. 2003;29:201-3.

https://doi.org/10.1046/j.1524-4725.2003.29030.x

PMid:12562357 

33. Trinh LN, McGuigan KC, Gupta A. Delayed Granulomas as a Complication Secondary to Lip Augmentation with Dermal Fillers: A Systematic Review. Surg J. 2022;8:e69-e79.

https://doi.org/10.1055/s-0042-1743524

PMid:35252562 PMCid:PMC8894086

34. Redaelli A, Siddiqui Syed S, Liu X, Poliziani M, Erbil H, Prygova I, et al. Two multinational, observational surveys investigating perceptions of beauty and attitudes and experiences relating to aesthetic medical procedures. Journal of Cosmetic Dermatology. 2020;19:3020-31.

https://doi.org/10.1111/jocd.13349

PMid:32153099 PMCid:PMC7687247

35. McKeown DJ. Impact of Minimally Invasive Aesthetic Procedures on the Psychological and Social Dimensions of Health. Plastic and reconstructive surgery. Global open. 2021;9:e3578.

https://doi.org/10.1097/GOX.0000000000003578

PMid:33936919 PMCid:PMC8081460

36. Shetty R. Outer Circle Versus Inner Circle: Special Considerations While Rejuvenating an Indian Face Using Fillers. J Cutan Aesthet Surg. 2015;8:169-72.

https://doi.org/10.4103/0974-2077.167281

PMid:26644742 PMCid:PMC4645148

37. Belezany K, Carruthers JDA, Humphrey S, Jones DJ. Avoiding and treating blindness from fillers: a review of the world literature. Dermatologic Surg. 2015;41:1097-117.

https://doi.org/10.1097/DSS.0000000000000486

PMid:26356847 

38. Walker L, King M. This month's guideline: Visual Loss Secondary to Cosmetic Filler Injection. J Clin Aesthet Dermatol. 2018;11:e53-5.

PMid:29785240