Zúñiga-López CM, Márquez-Pérez K, Argueta-Figueroa L, Bautista-Hernández MA, Torres-Rosas R. Chitosan for the treatment of inflammation of the oral mucosa: A systematic review. Med Oral Patol Oral Cir Bucal. 2024 Jan 1;29 (1):e9-17.
doi:10.4317/medoral.25987
https://dx.doi.org/doi:10.4317/medoral.25987
1. López-Jornet P, Camacho-Alonso F, Lucero Berdugo M. Measuring the impact of oral mucosa disease on quality of life. Eur J of Dermatol. 2009;19:603-6. |
PMid:19592326 |
2. Preeti L, Magesh K, Rajkumar K, Karthik R. Recurrent aphthous stomatitis. J Oral Maxillofac Pathol. 2011;15:252-6. |
PMid:22144824 PMCid:PMC3227248 |
3. Parra-Moreno FJ, Egido-Moreno S, Schemel-Suárez M, González-Navarro B, Estrugo-Devesa A, López-López J. Treatment of recurrent aphtous stomatitis: A systematic review. Med Oral Patol Oral Cir Bucal. 2023;28:e87-98. |
PMid:36173717 PMCid:PMC9805337 |
4. Ofluoglu D, Ergun S, Warnakulasuriya S, Namdar-Pekiner F, Tanyeri H. An evaluation of the efficacy of a topical gel with Triester Glycerol Oxide (TGO) in the treatment of minor recurrent aphthous stomatitis in a Turkish cohort: A randomized, double-blind, placebo-controlled clinical trial. Med Oral Patol Oral Cir Bucal. 2017;22:e159-e66. |
PMid:28160585 PMCid:PMC5359701 |
5. Kyriakidis I, Tragiannidis A, Munchen S, Groll AH. Clinical hepatotoxicity associated with antifungal agents. Expert Opin Drug Saf. 2017;16:149-65. |
PMid:27927037 |
6. Shetty SS, Maruthi M, Dhara V, de Arruda JAA, Abreu LG, Mesquita RA, et al. Oral mucositis: Current knowledge and future directions. Disease-a-Month. 2022;68:101300. |
PMid:34758917 |
7. Ren J, Du Z, Lin J, Chen Z, Feng X. Two Mixed-ligand Coordination Polymers: Treatment Activity on Acute Oral Mucositis during Orthodontic Process by Reducing Inflammatory Response. J Oleo Sci. 2020;69:1051-9. |
PMid:32879196 |
8. Raber-Durlacher JE, Elad S, Barasch A. Oral mucositis. Oral Oncol. 2010;46:452-6. |
PMid:20403721 |
9. Nigro O, Tuzi A, Tartaro T, Giaquinto A, Vallini I, Pinotti G. Biological effects of verbascoside and its anti-inflammatory activity on oral mucositis: a review of the literature. Anticancer Drugs. 2020;31:1-5. |
PMid:31609769 |
10. Teixeira DS, Louzeiro GC, Figueiredo MA, Cherubini K, Salum FG. Erythromycin: an alternative for the management of oral mucositis? Med Oral Patol Oral Cir Bucal. 2022;27:e452-e9. |
PMid:35717620 PMCid:PMC9445611 |
11. Inácio Silveira DQ, Lia EN, Massignan C, Stefani CM. Natural products for the treatment of denture stomatitis: A systematic review. J Prosthet Dent. 2023;129:413-24. |
PMid:34247854 |
12. Torres-Rosas R, Torres-Gomez N, Moreno-Rodriguez A, Garcia-Contreras R, Argueta-Figueroa L. Anti-Inflammatory and Antibacterial Activity of the Chitosan/Chlorhexidine Gel Commercial Preparation for Postexodontia Treatment: An In Vitro Study. Eur J Dent. 2020;14:397-403. |
PMid:32688408 PMCid:PMC7440956 |
13. Pavez L, Tobar N, Chacón C, Arancibia R, Martínez C, Tapia C, et al. Chitosan-triclosan particles modulate inflammatory signaling in gingival fibroblasts. J Periodontal Res. 2018;53:232-9. |
PMid:29067681 |
14. Arancibia R, Maturana C, Silva D, Tobar N, Tapia C, Salazar JC, et al. Effects of chitosan particles in periodontal pathogens and gingival fibroblasts. J Dent Res. 2013;92:740-5. |
PMid:23788611 |
15. Xu Q, Liu M, Liu Q, Wang W, Du Y, Yin H. The inhibition of LPS-induced inflammation in RAW264.7 macrophages via the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide. Carbohydr Polym. 2017;174:1138-43. |
PMid:28821038 |
16. Bilginaylar K, Aykac A, Sayiner S, Özkayalar H, Şehirli A. Evaluation of the antiapoptotic and anti-inflammatory properties of chitosan in methotrexate-induced oral mucositis in rats. Mol Biol Rep. 2022;49:3237-45. |
PMid:35064410 |
17. Khan F, Lee JW, Pham DTN, Kim YM. Chitooligosaccharides as Antibacterial, Antibiofilm, Antihemolytic and Anti-Virulence Agent against Staphylococcus aureus. Curr Pharm Biotechnol. 2019;20:1223-33. |
PMid:31475895 |
18. Shih PY, Liao YT, Tseng YK, Deng FS, Lin CH. A Potential Antifungal Effect of Chitosan Against Candida albicans Is Mediated via the Inhibition of SAGA Complex Component Expression and the Subsequent Alteration of Cell Surface Integrity. Front Microbiol. 2019;10:602. |
PMid:30972050 PMCid:PMC6443709 |
19. Ke CL, Liao YT, Lin CH. MSS2 maintains mitochondrial function and is required for chitosan resistance, invasive growth, biofilm formation and virulence in Candida albicans. Virulence. 2021;12:281-97. |
PMid:33427576 PMCid:PMC7808435 |
20. Wang CH, Cherng JH, Liu CC, Fang TJ, Hong ZJ, Chang SJ, et al. Procoagulant and Antimicrobial Effects of Chitosan in Wound Healing. Int J Mol Sci. 2021;22:7067. |
PMid:34209202 PMCid:PMC8269297 |
21. Howling GI, Dettmar PW, Goddard PA, Hampson FC, Dornish M, Wood EJ. The effect of chitin and chitosan on the proliferation of human skin fibroblasts and keratinocytes in vitro. Biomaterials. 2001;22:2959-66. |
PMid:11575470 |
22. Baxter RM, Dai T, Kimball J, Wang E, Hamblin MR, Wiesmann WP, et al. Chitosan dressing promotes healing in third degree burns in mice: Gene expression analysis shows biphasic effects for rapid tissue regeneration and decreased fibrotic signaling. J Biomed Mater Res A. 2013;101A:340-8. |
PMid:22847951 PMCid:PMC3488117 |
23. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097. |
PMid:19621072 PMCid:PMC2707599 |
24. Ambros-Antemate JF, Reyes-Flores A, Argueta-Figueroa L, Ramírez-Ramírez R, Vargas-Treviño M, Gutiérrez-Gutiérrez J, et al. Accuracy of machine learning algorithms for the assessment of upper-limb motor impairments in patients with post-stroke hemiparesis: A systematic review and meta-analysis. Adv Clin Exp Med. 2022;31:1309-18. |
PMid:36047897 |
25. Sterne JA, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. bmj. 2019;366:l4898. |
PMid:31462531 |
26. Gomez-Aguirre JN, Argueta-Figueroa L, Castro-Gutierrez MEM, Torres-Rosas R. Effects of interproximal enamel reduction techniques used for orthodontics: A systematic review. Orthod Craniofac Res. 2022;25:304-19. |
PMid:34865310 |
27. Atai Z, Atai M, Amini J, Salehi N. In vivo study of antifungal effects of low-molecular-weight chitosan against Candida albicans. J Oral Sci. 2017;59:425-30. |
PMid:28904319 |
28. Rahmani F, Moghadamnia AA, Kazemi S, Shirzad A, Motallebnejad M. Effect of 0.5% Chitosan mouthwash on recurrent aphthous stomatitis: a randomized double-blind crossover clinical trial. Electron Physician. 2018;10:6912-9. |
PMid:30034658 PMCid:PMC6049970 |
29. Mustafa MW, Ungphaiboon S, Phadoongsombut N, Pangsomboon K, Chelae S, Mahattanadul S. Effectiveness of an Alcohol-Free Chitosan-Curcuminoid Mouthwash Compared with Chlorhexidine Mouthwash in Denture Stomatitis Treatment: A Randomized Trial. J Altern Complement Med. 2019;25:552-8. |
PMid:30758216 |
30. Shao Y, Zhou H. Clinical evaluation of an oral mucoadhesive film containing chitosan for the treatment of recurrent aphthous stomatitis: a randomized, double-blind study. J Dermatolog Treat. 2020;31:739-43. |
PMid:31179773 |
31. Shi Y, Wei K, Lu J, Wei J, Hu X, Chen T. A Clinic Trial Evaluating the Effects of Aloe Vera Fermentation Gel on Recurrent Aphthous Stomatitis. Can J Infect Dis Med Microbiol. 2020;2020:1-9. |
PMid:33354266 PMCid:PMC7735858 |
32. Kusiak A, Jereczek-Fossa BA, Cichońska D, Alterio D. Oncological-Therapy Related Oral Mucositis as an Interdisciplinary Problem-Literature Review. Int J Environ Res Public Health. 2020;17:2464. |
PMid:32260309 PMCid:PMC7177874 |
33. Davydova VN, Kalitnik AA, Markov PA, Volod'ko AV, Popov SV, Ermak IM. Cytokine-inducing and anti-inflammatory activity of chitosan and its low-molecular derivative. Prikl Biokhim Mikrobiol. 2016;52:476-82. |
PMid:29513410 |
34. Ma Y, Tong X, Huang Y, Zhou X, Yang C, Chen J, et al. Oral Administration of Hydrogel-Embedding Silk Sericin Alleviates Ulcerative Colitis through Wound Healing, Anti-Inflammation, and Anti-Oxidation. ACS Biomater Sci Eng. 2019;5:6231-42. |
PMid:33405530 |
35. Kong M, Chen XG, Xing K, Park HJ. Antimicrobial properties of chitosan and mode of action: a state of the art review. Int J Food Microbiol. 2010;144:51-63. |
PMid:20951455 |