Silva PG, Barreto GA, Carlos AC, Borges MM, Malta CE, Barbosa JV, et al. Dysgeusia increases the risk for death and other side effects during antineoplastic systemic treatment for solid tumors: a cross-sectional study. Med Oral Patol Oral Cir Bucal. 2024 May 1;29 (3):e398-407.


doi:10.4317/medoral.26389

https://dx.doi.org/doi:10.4317/medoral.26389


1. Chaveli-López B. Oral toxicity produced by chemotherapy: A systematic review. J Clin Exp Dent. 2014;6:e81-90.

https://doi.org/10.4317/jced.51337

PMid:24596641 PMCid:PMC3935911

2. Malta CEN, de Lima Martins JO, Carlos ACAM, Freitas MO, Magalhães IA, de Vasconcelos HCA, et al. Risk factors for dysgeusia during chemotherapy for solid tumors: a retrospective cross-sectional study. Support Care Cancer. 2022;30:313-25.

https://doi.org/10.1007/s00520-021-06219-4

PMid:34283319 

3. Ponticelli E, Clari M, Frigerio S, De Clemente A, Bergese I, Scavino E, et al .Dysgeusia and health-related quality of life of cancer patients receiving chemotherapy: A cross-sectional study. Eur J Cancer Care (Engl). 2017;26:e12633.

https://doi.org/10.1111/ecc.12633

PMid:28101929 

4. Irune E, Dwivedi RC, Nutting CM, Harrington KJ. Treatment-related dysgeusia in head and neck cancer patients. Cancer Treat Rev. 2014;40:1106-17.

https://doi.org/10.1016/j.ctrv.2014.06.011

PMid:25064135 

5. Akbarali HI, Muchhala KH, Jessup DK, Cheatham S. Chemotherapy induced gastrointestinal toxicities. Adv Cancer Res. 2022;155:131-66.

https://doi.org/10.1016/bs.acr.2022.02.007

PMid:35779873 PMCid:PMC10033220

6. Malta CEN, Carlos ACAM, de Alencar MCM, Alves E, Silva EF, Alves APNN, et al. Photobiomodulation therapy prevents dysgeusia chemotherapy induced in breast cancer women treated with doxorubicin plus cyclophosphamide: a triple-blinded, randomized, placebo-controlled clinical trial. Support Care Cancer. 2022;30:2569-80.

https://doi.org/10.1007/s00520-021-06642-7

PMid:34799776 

7. Bozzetti F, Mariani L. Defining and classifying cancer cachexia: A proposal by the SCRINIO Working Group. JPEN J Parenter Enter Nutr. 2009;33:361-7.

https://doi.org/10.1177/0148607108325076

PMid:19109514 

8. Fejzo MS, Trovik J, Grooten IJ, Sridharan K, Roseboom TJ, Vikanes Å, et al. Nausea and vomiting of pregnancy and hyperemesis gravidarum. Nat Rev Dis Prim. 2019;5:62.

https://doi.org/10.1038/s41572-019-0110-3

PMid:31515515 

9. Dahlgren D, Rosenqvist E, Hellström PM, Nygren P, Kullenberg F, Peters K, et al. Evaluation and validation of chemotherapy-specific diarrhea and histopathology in rats. Basic Clin Pharmacol Toxicol. 2022;131:536-46.

https://doi.org/10.1111/bcpt.13790

PMid:36124882 PMCid:PMC9828157

10. Zabernigg A, Gamper EM, Giesinger JM, Rumpold G, Kemmler G, Gattringer K, et al. Taste alterations in cancer patients receiving chemotherapy: a neglected side effect?. Oncologist. 2010;15:913-20.

https://doi.org/10.1634/theoncologist.2009-0333

PMid:20667968 PMCid:PMC3228016

11. Denda Y, Niikura N, Satoh-Kuriwada S, Yokoyama K, Terao M, Morioka T, et al. Taste alterations in patients with breast cancer following chemotherapy: a cohort study. Breast Cancer. 2020;27:954-62.

https://doi.org/10.1007/s12282-020-01089-w

PMid:32301097 

12. Gamper EM, Giesinger JM, Oberguggenberger A, Kemmler G, Wintner LM, Gattringer K, et al. Taste alterations in breast and gynaecological cancer patients receiving chemotherapy: prevalence, course of severity, and quality of life correlates. Acta Oncol. 2012;51:490-6.

https://doi.org/10.3109/0284186X.2011.633554

PMid:22129358 

13. Gadisa DA, Wang SH, Yimer G. The Impact of AC and AC-T chemotherapy's toxicities on quality of life among women with breast cancer in Ethiopia: A prospective patient-reported outcomes study. Breast Cancer (Dove Med Press). 2021;13:107-32.

https://doi.org/10.2147/BCTT.S289014

PMid:33658844 PMCid:PMC7917350

14. Amézaga J, Alfaro B, Ríos Y, Larraioz A, Ugartemendia G, Urruticoechea A, et al. Assessing taste and smell alterations in cancer patients undergoing chemotherapy according to treatment. Support Care Cancer. 2018;26:4077-86.

https://doi.org/10.1007/s00520-018-4277-z

PMid:29855774 

15. Mossman KL. Gustatory tissue injury in man: radiation dose response relationships and mechanisms of taste loss. Br J Cancer Suppl. 1986;7:9-11.

PMid:3459546

16. Epstein JB, Barasch A. Taste disorders in cancer patients: pathogenesis, and approach to assessment and management. Oral Oncol. 2010;46:77-81.

https://doi.org/10.1016/j.oraloncology.2009.11.008

PMid:20036797 

17. Bressan V, Stevanin S, Bianchi M, Aleo G, Bagnasco A, Sasso L. The effects of swallowing disorders, dysgeusia, oral mucositis and xerostomia on nutritional status, oral intake and weight lossin head and neck cancer patients: a systematic review. Cancer Treat Rev. 2016;45:105-19.

https://doi.org/10.1016/j.ctrv.2016.03.006

PMid:27010487 

18. Pugnaloni S, Vignini A, Borroni F, Sabbatinelli J, Alia S, Fabri M, et al. Modifications of taste sensitivity in cancer patients: a method for the evaluations of dysgeusia. Support Care Cancer. 2020;28:1173-81.

https://doi.org/10.1007/s00520-019-04930-x

PMid:31203507 

19. Rha SY, Lee J. Symptom clusters during palliative chemotherapy and their influence on functioning and quality of life. Support Care Cancer. 2017;25:1519-27.

https://doi.org/10.1007/s00520-016-3545-z

PMid:28032218 

20. Ogata R, Yamamoto Y, Jo A, Fukuma Y, Mikami T, Kawano S, et al. Neoadjuvant Epirubicin-Cyclophosphamide Therapy followed by Nab-Paclitaxel in Patients with Operable Breast Cancer-A Single-Center Phase Trial. Gan To Kagaku Ryoho. 2022;49:677-82.

PMid:35799395

21. Escalante J, McQuade RM, Stojanovska V, Nurgali K. Impact of chemotherapy on gastrointestinal functions and the enteric nervous system. Maturitas. 2017;105:23-9.

https://doi.org/10.1016/j.maturitas.2017.04.021

PMid:28545907 

22. Costa M, Brookes S. Architecture of enteric neural circuits involved in intestinal motility. Eur Rev Med Pharmacol Sci. 2008;12:3-19.

PMid:18924440

23. Hinkelmann JV, Possa LO, de Oliveira CA, Faria BS, Hermsdorff HHM, Rosa COB. Food preferences and aversions of patients undergoing chemotherapy, radiotherapy and/or hematopoietic stem cell transplantation. Clin Nutr ESPEN. 2021;44:331-6.

https://doi.org/10.1016/j.clnesp.2021.05.023

PMid:34330486 

24. de Vries YC, van den Berg MMGA, de Vries JHM, Boesveldt S, de Kruif JTCM, Buist N, et al. Differences in dietary intake during chemotherapy in breast cancer patients compared to women without cancer. Support Care Cancer. 2017;25:2581-91.

https://doi.org/10.1007/s00520-017-3668-x

PMid:28303381 PMCid:PMC5486772

25. Agate L, Minaldi E, Basolo A, Angeli V, Jaccheri R, Santini F, et al. Nutrition in Advanced Thyroid Cancer Patients. Nutrients. 2022;18;14:1298.

https://doi.org/10.3390/nu14061298

PMid:35334955 PMCid:PMC8951395

26. Prieto-Callejero B, Rivera F, Fagundo-Rivera J, Romero A, Romero-Martín M, Gómez-Salgado J, et al. Relationship between chemotherapy-induced adverse reactions and health-related quality of life in patients with breast cancer. Medicine (Baltimore). 2020;99:e21695.

https://doi.org/10.1097/MD.0000000000021695

PMid:32872042 PMCid:PMC7437745

27. Sánchez-Lara K, Sosa-Sánchez R, Green-Renner D, Rodríguez C, Laviano A, Motola-Kuba D, et al. Influence of taste disorders on dietary behaviors in cancer patients under chemotherapy. Nutr J. 2010;24;9:15.

https://doi.org/10.1186/1475-2891-9-15

PMid:20334666 PMCid:PMC2858711

28. Martins JO, Borges MM, Malta CE, Carlos AC, Crispim AA, Moura JF, et al. Risk factors for oral mucositis during chemotherapy treatment for solid tumors: a retrospective STROBE-guided study. Med Oral Patol Oral Cir Bucal. 2022;27:e319-29.

https://doi.org/10.4317/medoral.25253

PMid:35717621 PMCid:PMC9271342

29. Chitapanarux I, Wongsrita S, Sripan P, Kongsupapsiri P, Phakoetsuk P, Chachvarat S, et al. An underestimated pitfall of oral candidiasis in head and neck cancer patients undergoing radiotherapy: an observation study. BMC Oral Health. 2021;21:353.

https://doi.org/10.1186/s12903-021-01721-x

PMid:34271901 PMCid:PMC8285796

30. Nobre LMS, Fernandes C, Florêncio KGD, Alencar NMN, Wong DVT, Lima-Júnior RCP. Could paraprobiotics be a safer alternative to probiotics for managing cancer chemotherapy-induced gastrointestinal toxicities?. Braz J Med Biol Res. 2023;55:e12522.

https://doi.org/10.1590/1414-431x2022e12522

PMid:36651453 PMCid:PMC9843735