1. Bjørndal L, Simon S, Tomson PL, Duncan HF. Management of deep caries and the exposed pulp. Int Endod J. 2019;52:949-73.

https://doi.org/10.1111/iej.13128

PMid:30985944 

2. Kakehashi S, Stanley HR, Fitzgerald RJ. The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats. Oral Surg Oral Med Oral Pathol. 1965;20:340-49.

https://doi.org/10.1016/0030-4220(65)90166-0

PMid:14342926 

3. Silva BSF, Bueno MR, Yamamoto-Silva FP, Gomez RS, Peters OA, Estrela C. Differential diagnosis and clinical management of periapical radiopaque/hyperdense jaw lesions. Braz Oral Res. 2017;31:e52.

https://doi.org/10.1590/1807-3107bor-2017.vol31.0052

PMid:28678971

4. Tibúrcio-Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA, Bier CA. The global prevalence of apical periodontitis: a systematic review and meta-analysis. Int Endod J. 2021;54:712-35.

https://doi.org/10.1111/iej.13467

PMid:33378579 

5. Segura-Egea JJ, Martín-González J, Castellanos-Cosano L. Endodontic medicine: connections between apical periodontitis and systemic diseases. Int Endod J. 2015;48:933-51.

https://doi.org/10.1111/iej.12507

PMid:26174809 

6. Segura-Egea JJ, Cabanillas-Balsera D, Jiménez-Sánchez MC, Martín-González J. Endodontics and diabetes: association versus causation. Int Endod J. 2019;52:790-802.

https://doi.org/10.1111/iej.13079

PMid:30667519 

7. Jiménez-Sánchez MC, Cabanillas-Balsera D, Areal-Quecuty V, Velasco-Ortega E, Martín-González J, Segura-Egea JJ. Cardiovascular diseases and apical periodontitis: association not always implies causality. Med Oral Patol Oral Cir Bucal. 2020;25:e652-9.

https://doi.org/10.4317/medoral.23665

PMid:32388515 PMCid:PMC7473437

8. González-Navarro B, Segura-Egea JJ, Estrugo-Devesa A, Pintó-Sala X, Jane-Salas E, Jiménez-Sánchez MC, et al. Relationship between apical periodontitis and metabolic syndrome and cardiovascular events: A cross-sectional study. J Clin Med. 2020;9:1-13.

https://doi.org/10.3390/jcm9103205

PMid:33020413 PMCid:PMC7600401

9. Castellanos-Cosano L, Machuca-Portillo G, Sánchez-Domínguez B, Torrés-Lagares D, López-López J, Segura-Egea JJ. High prevalence of radiolucent periapical lesions amongst patients with inherited coagulation disorders. Haemophilia. 2013;19:110-15.

https://doi.org/10.1111/hae.12089

PMid:23320531 

10. Halboub E, Al-Maswary A, Mashyakhy M, Al-Qadhi G, Al-Maweri SA, Ba-Hattab R, et al. The potential association between inflammatory bowel diseases and apical periodontitis: a systematic review and meta-analysis. Eur Endod J. 2024;9:8-17.

https://doi.org/10.14744/eej.2023.74507

PMid:37968968 PMCid:PMC10777093

11. Jakovljevic A, Ideo F, Jacimovic J, Aminoshariae A, Nagendrababu V, Azarpazhooh A, et al. The link between apical periodontitis and gastrointestinal diseases-a systematic review. J Endod. 2023;49:1421-31.

https://doi.org/10.1016/j.joen.2023.07.024

PMid:37558178 

12. Palmeira E, de Liz Pérez-Losada F, Díaz-Flores-García V, Segura-Sampedro JJ, Segura-Egea JJ, López-López J. Prevalence of oral infections in chronic kidney disease patients: A cross-sectional study. Oral Dis. 2023; doi: 10.1111/odi.14663. Epub ahead of print. PMID: 37392430.

https://doi.org/10.1111/odi.14663

PMid:37392430 

13. Castellanos-Cosano L, Machuca-Portillo G, Segura-Sampedro JJ, Torres-Lagares D, López-López J, Velasco-Ortega E, et al. Prevalence of apical periodontitis and frequency of root canal treatments in liver transplant candidates. Med Oral Patol Oral Cir Bucal. 2013;18:e773-9.

https://doi.org/10.4317/medoral.19148

PMid:23722148 PMCid:PMC3790651

14. Väänänen HK, Härkönen PL. Estrogen and bone metabolism. Maturitas. 1996;23(SUPPL.):s65-9.

https://doi.org/10.1016/0378-5122(96)01015-8

PMid:8865143 

15. Eastell R, O'Neill TW, Hofbauer LC, Langdahl B, Reid IR, Gold DT, Cummings SR. Postmenopausal osteoporosis. Nat Rev Dis Primers. 2016;2:16069.

https://doi.org/10.1038/nrdp.2016.69

PMid:27681935 

16. López-López J, Castellanos-Cosano L, Estrugo-Devesa A, Gómez-Vaquero C, Velasco-Ortega E, Segura-Egea JJ. Radiolucent periapical lesions and bone mineral density in post-menopausal women. Gerodontology. 2015;32:195-201.

https://doi.org/10.1111/ger.12076

PMid:24164489 

17. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.

https://doi.org/10.1136/bmj.n71

PMid:33782057 PMCid:PMC8005924

18. Herzog R, Álvarez-Pasquin MJ, Díaz C, Del Barrio JL, Estrada JM, Gil A. Are healthcare workers intentions to vaccinate related to their knowledge, beliefs and attitudes? A systematic review. BMC Public Health. 2013;13:154.

https://doi.org/10.1186/1471-2458-13-154

PMid:23421987 PMCid:PMC3602084

19. León-López M, Cabanillas-Balsera D, Martín-González J, Montero-Miralles P, Saúco-Márquez JJ, Segura-Egea JJ. Prevalence of root canal treatment worldwide: A systematic review and meta-analysis. Int Endod J. 2022;55:1105-27.

https://doi.org/10.1111/iej.13822

PMid:36016509 PMCid:PMC9826350

20. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-88.

https://doi.org/10.1016/0197-2456(86)90046-2

PMid:3802833 

21. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539-58.

https://doi.org/10.1002/sim.1186

PMid:12111919 

22. Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, et al. GRADE guidelines: 1. Introduction - GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64:383-94.

https://doi.org/10.1016/j.jclinepi.2010.04.026

PMid:21195583 

23. Hultcrantz M, Rind D, Akl EA, Treweek S, Mustafa RA, Iorio A, et al. The GRADE Working Group clarifies the construct of certainty of evidence. J Clin Epidemiol. 2017;87:4-13.

https://doi.org/10.1016/j.jclinepi.2017.05.006

PMid:28529184 PMCid:PMC6542664

24. Guan X, Guan Y, Shi C, Zhu X, He Y, Wei Z, et al. Estrogen deficiency aggravates apical periodontitis by regulating NLRP3/caspase-1/IL-1β axis. Am J Transl Res. 2020;12:660-71.

PMid:32194913

25. Thanakun S, Pornprasertsuk-Damrongsri S, Na Mahasarakham CP, Techatanawat S, Izumi Y. Increased plasma osteocalcin, oral disease, and altered mandibular bone density in postmenopausal women. Int J Dent. 2019;2019:3715127.

https://doi.org/10.1155/2019/3715127

PMid:31781221 PMCid:PMC6855022

26. Katz J, Rotstein I. Prevalence of periapical lesions in patients with osteoporosis. J Endod. 2021;47:234-38.

https://doi.org/10.1016/j.joen.2020.10.019

PMid:33130060 

27. Cadoni E, Ideo F, Marongiu G, Mezzena S, Frigau L, Mela Q, et al. Periapical status in patients affected by osteoporosis: A retrospective clinical study. Clin Exp Dent Res. 2022;8:1068-75.

https://doi.org/10.1002/cre2.604

PMid:35698910 PMCid:PMC9562578

28. Cintra LTA, Gomes MS, da Silva CC, Faria FD, Benetti F, Cosme-Silva L, et al. Evolution of endodontic medicine: a critical narrative review of the interrelationship between endodontics and systemic pathological conditions. Odontology. 2021;109:741-69.

https://doi.org/10.1007/s10266-021-00636-x

PMid:34240297 

29. Segura-Egea JJ, Cabanillas-Balsera D, Martín-González J, Cintra LTA. Impact of systemic health on treatment outcomes in endodontics. Int Endod J. 2023;56:219-35.

https://doi.org/10.1111/iej.13789

PMid:35752972 

30. Ciesielska A, Kusiak A, Ossowska A, Grzybowska ME. Changes in the oral cavity in menopausal women-a narrative review. Int J Environ Res Public Health. 2021;19:253.

https://doi.org/10.3390/ijerph19010253

PMid:35010513 PMCid:PMC8750983

31. Xu XC, Chen H, Zhang X, Zhai ZJ, Liu XQ, Zheng XY, et al. Effects of oestrogen deficiency on the alveolar bone of rats with experimental periodontitis. Mol Med Rep. 2015;12:3494-502.

https://doi.org/10.3892/mmr.2015.3875

PMid:26035209 PMCid:PMC4526094

32. Tezal M, Wactawski‐Wende J, Grossi SG, Ho AW, Dunford R, Genco RJ. The relationship between bone mineral density and periodontitis in postmenopausal women. J Periodontol. 2000;71:1492-98.

https://doi.org/10.1902/jop.2000.71.9.1492

PMid:11022780 

33. Mazur I, Dilbarkhanov B, Kuracha X, Novoshytskyy V, Suprunovych I, Zhakipbekov K. Periodontal status and bone metabolism in women in reproductive and postmenopausal periods. Horm Mol Biol Clin Investig. 2020;41(3).

https://doi.org/10.1515/hmbci-2020-0011

PMid:32739905 

34. Payne JB, Reinhardt RA, Nummikoski PV, Patil KD. Longitudinal alveolar bone loss in postmenopausal osteoporotic/osteopenic women. Osteoporos Int. 1999;10:34-40.

https://doi.org/10.1007/s001980050191

PMid:10501777 

35. Jonasson G, Jonasson L, Kiliaridis S. Skeletal bone mineral density in relation to thickness, bone mass, and structure of the mandibular alveolar process in dentate men and women. Eur J Oral Sci. 2007;115:117-23.

https://doi.org/10.1111/j.1600-0722.2007.00438.x

PMid:17451501 

36. Estrugo-Devesa A, Segura-Egea J, García-Vicente L, Schemel-Suárez M, Blanco-Carrrión Á, Jané-Salas E, et al. Correlation between mandibular bone density and skeletal bone density in a Catalonian postmenopausal population. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125:495-502.

https://doi.org/10.1016/j.oooo.2017.10.003

PMid:29198430 

37. Rohlin M, Kullendorff B, Ahlqwist M, Henrikson CO, Hollender L, Stenström B. Comparison between panoramic and periapical radiography in the diagnosis of periapical bone lesions. Dentomaxillofac Radiol. 1989;18:151-55.

https://doi.org/10.1259/dmfr.18.4.2640445

PMid:2640445 

38. Molander B, Ahlqwist M, Gröndahl HG, Hollender L. Comparison of panoramic and intraoral radiography for the diagnosis of caries and periapical pathology. Dentomaxillofac Radiol. 1993;22:28-32.

https://doi.org/10.1259/dmfr.22.1.8508938

PMid:8508938