Wei T, Fan Y, Li S, Cai Y, Peng X, Ye P. Spontaneous bone regeneration in segmental mandibular defects: A systematic review. Med Oral Patol Oral Cir Bucal. 2024 Nov 1;29 (6):e758-67.


doi:10.4317/medoral.26712

https://dx.doi.org/doi:10.4317/medoral.26712


1. Nauth A, Schemitsch E, Norris B, Nollin Z, Watson JT. Critical-size bone defects: is there a consensus for diagnosis and treatment?. J Orthop Trauma. 2018;32:S7-11.

https://doi.org/10.1097/BOT.0000000000001115

PMid:29461395 

2. Ishikawa K, Yamamoto Y, Furukawa H, Ohiro Y, Satoh A, Hayashi T. Long-term changes in bone height after mandibular reconstruction using a free fibula graft in an elderly population. J Oral Maxillofac Surg. 2017;75:2682-8.

https://doi.org/10.1016/j.joms.2017.05.011

PMid:28627358 

3. Kazanjian VH. Spontaneous regeneration of bone following excision of section of the mandible. Am J Orthod Oral Surg. 1946;32:242-8.

https://doi.org/10.1016/0096-6347(46)90016-6

PMid:21022285 

4. Byars LT, Schatten WE. Subperiosteal segmental resection of the mandible. Plast Reconstr Surg Transplant Bull. 1960;25:142-5.

https://doi.org/10.1097/00006534-196002000-00003

PMid:13806604 

5. Munn Z, Moola S, Lisy K, Riitano D, Tufanaru C. Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data. Int J Evid Based Healthc. 2015;13:147-53.

https://doi.org/10.1097/XEB.0000000000000054

PMid:26317388 

6. Budal J. The surgical removal of large osteofibromas. The postoperative osteogenic capacity of the periosteum. Oral Surg Oral Med Oral Patho. 1970;30:303-8.

https://doi.org/10.1016/0030-4220(70)90305-1

PMid:5270880 

7. Adekeye EO. Rapid bone regeneration subsequent to subtotal mandibulectomy. Report of an unusual case. Oral Surg Oral Med Oral Pathol. 1977;44:521-6.

https://doi.org/10.1016/0030-4220(77)90293-6

PMid:269349 

8. Nwoku AL. Unusually rapid bone regeneration following mandibular resection. J Maxillofac Surg. 1980;8:309-15.

https://doi.org/10.1016/S0301-0503(80)80119-6

PMid:6936514 

9. Kisner WH. Spontaneous posttraumatic mandibular regeneration. Plast Reconstr Surg. 1980;66:442-7.

https://doi.org/10.1097/00006534-198066030-00023

PMid:7422730 

10. Shuker S. Spontaneous regeneration of the mandible in a child. A sequel to partial avulsion as a result of a war injury. J Maxillofac Surg. 1985;13:70-3.

https://doi.org/10.1016/S0301-0503(85)80019-9

PMid:3858397 

11. Nagase M, Ueda K, Suzuki I, Nakajima T. Spontaneous regeneration of the condyle following hemimandibulectomy by disarticulation. J Oral Maxillofac Surg. 1985;43:218-20.

https://doi.org/10.1016/0278-2391(85)90164-8

PMid:3882921 

12. Yamashiro M, Amagasa T, Horiuchi J, Komori A. Extensive osteoradionecrosis of the mandible associated with new bone formation. J Oral Maxillofac Surg. 1987;45:630-3.

https://doi.org/10.1016/0278-2391(87)90277-1

PMid:3474380 

13. Elbeshir EI. Spontaneous regeneration of the mandibular bone following hemimandibulectomy. Br J Oral Maxillofac Surg. 1990;28:128-30.

https://doi.org/10.1016/0266-4356(90)90140-G

PMid:2186799 

14. Ruggiero SL, Donoff RB. Bone regeneration after mandibular resection: Report of two cases. J Oral Maxillofac Surg. 1991;49:647-52.

https://doi.org/10.1016/0278-2391(91)90349-Q

PMid:2037923 

15. Whitmyer CC, Esposito SJ, Smith JD, Zins JE. Spontaneous regeneration of a resected mandible in a preadolescent: A clinical report. J Prosthet Dent. 1996;75:356-9.

https://doi.org/10.1016/S0022-3913(96)90024-4

PMid:8642518 

16. de Villa GH, Chen CT, Chen YR. Spontaneous bone regeneration of the mandible in an elderly patient: A case report and review of the literature. Chang Gung Med J. 2003;26:363-9.

PMid:12934854

17. Coen Pramono D. Spontaneous bone regeneration after mandible resection in a case of ameloblastoma--a case report. Ann Acad Med Singap. 2004;33:59-62.

https://doi.org/10.47102/annals-acadmedsg.V33N4p59S

PMid:15389310 

18. Martins WD, de Castro Avila LF. Partial spontaneous bone regeneration subsequent to mandibulectomy. J Contemp Dent Pract. 2004;5:108-20.

https://doi.org/10.5005/jcdp-5-3-108

PMid:15318262 

19. Ogunlewe MO, Akinwande JA, Ladeinde AL, Adeyemo WL. Spontaneous regeneration of whole mandible after total mandibulectomy in a sickle cell patient. J Oral Maxillofac Surg. 2006;64:981-4.

https://doi.org/10.1016/j.joms.2006.02.008

PMid:16713818 

20. Espinosa SA, Villanueva J, Hampel H, Reyes D. Spontaneous regeneration after juvenile ossifying fibroma resection: A case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:e32-5.

https://doi.org/10.1016/j.tripleo.2006.03.027

PMid:17052621 

21. Khodayari A, Khojasteh A, Kiani M, Nayebi A, Mehrdad L, Vahdatinia M. Spontaneous regeneration of the mandible after hemimandibulectomy: Report of a case. J Dent (Tehran). 2011;8:152-6.

PMid:22457843

22. Wilde F, Hendricks J, Riese C, Pausch N C, Schramm A, Heufelder M. Bone regeneration without bone grafting after resection of a segment of the mandible to treat bisphosphonate-related osteonecrosis of the jaw. J Oral Maxillofac Surg. 2011;69:2657-62.

https://doi.org/10.1016/j.joms.2011.02.037

PMid:21741741 

23. Abdulai AE. Complete spontaneous bone regeneration following partial mandibulectomy. Ghana Med J. 2012;46:174-7.

PMid:23661834

24. Adebayo ET, Fomete B, Ajike SO. Spontaneous bone regeneration following mandibular resection for odontogenic myxoma. Ann Afr Med. 2012;11:182-5.

https://doi.org/10.4103/1596-3519.96882

PMid:22684138 

25. Sharma P, Williams R, Monaghan A. Spontaneous mandibular regeneration: Another option for mandibular reconstruction in children?. Br J Oral Maxillofac Surg. 2013;51:e63-6.

https://doi.org/10.1016/j.bjoms.2012.04.255

PMid:22578705 

26. Sorin T, Mansuy L, Colson T, Minetti C, Brix M, Simon E. Ewing's sarcoma of the mandible in children: Reconstruction by induced membrane. Rev Stomatol Chir Maxillofac Chir Orale. 2014;115:318-22.

https://doi.org/10.1016/j.revsto.2014.05.001

PMid:25001547 

27. Ahmad O, Omami G. Self-regeneration of the mandible following hemimandibulectomy for ameloblastoma: A case report and review of literature. J Maxillofac Oral Surg. 2015;14:245-50.

https://doi.org/10.1007/s12663-012-0462-7

PMid:25861189 PMCid:PMC4379248

28. Zhang Z, Hu J, Ma J, Pan J. Spontaneous regeneration of bone after removal of a vascularised fibular bone graft from a mandibular segmental defect: A case report. Br J Oral Maxillofac Surg. 2015;53:650-1.

https://doi.org/10.1016/j.bjoms.2015.04.002

PMid:25960023 

29. Anyanechi CE, Saheeb BD, Bassey GO. Spontaneous bone regeneration after segmental mandibular resection: a retrospective study of 13 cases. Int J Oral Maxillofac Surg. 2016;45:1268-72.

https://doi.org/10.1016/j.ijom.2016.04.011

PMid:27138240 

30. Okoturo E, Ogunbanjo OV, Arotiba GT. Spontaneous regeneration of the mandible: An institutional audit of regenerated bone and osteocompetent periosteum. J Oral Maxillofac Surg. 2016;74:1660-7.

https://doi.org/10.1016/j.joms.2016.02.007

PMid:26970145 

31. Chatzistefanou I, Kabesi S, Paraskevopoulos K, Koliouskas D, Antoniades K. Ewing's sarcoma of mandible: An impressive case of spontaneous mandible regeneration. Int J Clin Pediatr Dent. 2016;9:273-7.

https://doi.org/10.5005/jp-journals-10005-1376

PMid:27843262 PMCid:PMC5086018

32. Fauvel F, Pace R, Grimaud F, Marion F, Corre P, Piot B. Costal graft as a support for bone regeneration after mandibular juvenile ossifying fibroma resection: An unusual case report. J Stomatol Oral Maxillofac Surg. 2017;118:320-5.

https://doi.org/10.1016/j.jormas.2017.06.003

PMid:28642188 

33. Hakobyan K, Poghosyan Y. Spontaneous bone formation after mandible segmental resection in "krokodil" drug-related jaw osteonecrosis patient: case report. Oral Maxillofac Surg. 2017;21:267-70.

https://doi.org/10.1007/s10006-017-0613-6

PMid:28251363 

34. Mesgarzadeh AH, Abadi A, Keshani F. Seven-year follow-up of spontaneous bone regeneration following segmental mandibulectomy: Alternative option for mandibular reconstruction. Dent Res J (Isfahan). 2019;16:435-40.

https://doi.org/10.4103/1735-3327.270780

PMid:31803391 

35. Rai S, Rattan V, Jolly SS, Sharma VK, Mubashir MM. Spontaneous regeneration of bone in segmental mandibular defect. J Maxillofac Oral Surg. 2019;18:224-8.

https://doi.org/10.1007/s12663-018-1153-9

PMid:30996542 PMCid:PMC6441417

36. Esen A, Gurses G, Akkulah S. Spontaneous bone regeneration in resected non-continuous mandible due to medication-related osteonecrosis of the jaw. J Korean Assoc Oral Maxillofac Surg. 2021;47:465-70.

https://doi.org/10.5125/jkaoms.2021.47.6.465

PMid:34969020 PMCid:PMC8721417

37. Shirafkan S, Gholamian M, Rohani A, Mahmoudinezhad SS, Razavi M, Moradi K. Complete spontaneous bone regeneration following surgical enucleation of a mandibular cemento-ossifying fibroma. Case Rep Dent. 2022;2022:7902602.

https://doi.org/10.1155/2022/7902602

PMid:36034160 PMCid:PMC9411006

38. Smartt JMJr, Low DW, Bartlett SP. The pediatric mandible: I. A primer on growth and development. Plast Reconstr Surg. 2005;116:14e-23.

https://doi.org/10.1097/01.PRS.0000169940.69315.9C

PMid:15988242 

39. Nahhas RW, Valiathan M, Sherwood RJ. Variation in timing, duration, intensity, and direction of adolescent growth in the mandible, maxilla, and cranial base: the Fels longitudinal study. Anat Rec (Hoboken). 2014;297:1195-207.

https://doi.org/10.1002/ar.22918

PMid:24737730 PMCid:PMC4103980

40. Jewer DD, Boyd JB, Manktelow RT, Zuker RM, Rosen IB, Gullane PJ, et al. Orofacial and mandibular reconstruction with the iliac crest free flap: A review of 60 cases and a new method of classification. Plast Reconstr Surg. 1989;84:391-403.

https://doi.org/10.1097/00006534-198909000-00001

PMid:2762397