González-Moles MÁ, Ramos-García P. Malignant transformation of oral lichen planus: where are we now?. Med Oral Patol Oral Cir Bucal. 2025 Jan 1;30 (1):e65-75.


doi:10.4317/medoral.26834

https://dx.doi.org/doi:10.4317/medoral.26834


1. Reeve MP, Vehviläinen M, Luo S, Ritari J, Karjalainen J, Gracia-Tabuenca J, et al. Oral and non-oral lichen planus show genetic heterogeneity and differential risk for autoimmune disease and oral cancer. Am J Hum Genet. 2024;111:1047-60.

https://doi.org/10.1016/j.ajhg.2024.04.020

PMid:38776927 PMCid:PMC11179409

2. González-Moles MÁ, Ramos-García P. Oral lichen planus and related lesions. What should we accept based on the available evidence? Oral Dis. 2023;29:2624-37.

https://doi.org/10.1111/odi.14438

PMid:36371653 

3. González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, González-Ruiz L, Ayén Á, Lenouvel D, et al. Worldwide prevalence of oral lichen planus: A systematic review and meta-analysis. Oral Dis. 2021;27:813-28.

https://doi.org/10.1111/odi.13323

PMid:32144836 

4. Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, et al. Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer. Oral Dis. 2021;27:1862-80.

https://doi.org/10.1111/odi.13704

PMid:33128420 

5. Gonzalez-Moles MA, Scully C, Gil-Montoya JA. Oral lichen planus: controversies surrounding malignant transformation. Oral Dis. 2008;14:229-43.

https://doi.org/10.1111/j.1601-0825.2008.01441.x

PMid:18298420 

6. Kramer IR, Lucas RB, Pindborg JJ, Sobin LH. Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol. 1978;46:518-39.

https://doi.org/10.1016/0030-4220(78)90383-3

PMid:280847 

7. van der Meij EH, van der Waal I. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. J Oral Pathol Med. 2003;32:507-12.

https://doi.org/10.1034/j.1600-0714.2003.00125.x

PMid:12969224 

8. Cheng YS, Gould A, Kurago Z, Fantasia J, Muller S. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:332-54.

https://doi.org/10.1016/j.oooo.2016.05.004

PMid:27401683 

9. González-Moles MÁ, Ramos-García P, Warnakulasuriya S. An appraisal of highest quality studies reporting malignant transformation of oral lichen planus based on a systematic review. Oral Dis. 2021;27:1908-18.

https://doi.org/10.1111/odi.13741

PMid:33274561 

10. Gonzalez-Moles MA, Gil-Montoya JA, Ruiz-Avila I, Bravo M. Is oral cancer incidence among patients with oral lichen planus/oral lichenoid lesions underestimated? J Oral Pathol Med. 2017;46:148-53.

https://doi.org/10.1111/jop.12480

PMid:27426232 

11. Idrees M, Kujan O, Shearston K, Farah CS. Oral lichen planus has a very low malignant transformation rate: A systematic review and meta-analysis using strict diagnostic and inclusion criteria. J Oral Pathol Med. 2021;50:287-98.

https://doi.org/10.1111/jop.12996

PMid:31981238 

12. Krutchkoff DJ, Cutler L, Laskowski S. Oral lichen planus: the evidence regarding potential malignant transformation. J Oral Pathol. 1978;7:1-7.

https://doi.org/10.1111/j.1600-0714.1978.tb01879.x

PMid:418159 

13. Krutchkoff DJ, Eisenberg E. Lichenoid dysplasia: a distinct histopathologic entity. Oral Surg Oral Med Oral Pathol. 1985;60:308-15.

https://doi.org/10.1016/0030-4220(85)90315-9

PMid:3862044 

14. González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, Ayén Á, González-Ruiz L, Ruiz-Ávila I, et al. Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper. Med Oral Patol Oral Cir Bucal. 2021;26:e541-8.

https://doi.org/10.4317/medoral.24610

PMid:34162824 PMCid:PMC8254877

15. Pimolbutr K, Lim WT, Leeson R, Hopper C, Kalavrezos N, Liew C, et al. Prognosis of oral epithelial dysplasia in individuals with and without oral lichen planus. Oral Dis. 2024;30:504-17.

https://doi.org/10.1111/odi.14503

PMid:36648368 

16. Rock LD, Laronde DM, Lin I, Rosin MP, Chan B, Shariati B, et al. Dysplasia Should Not Be Ignored in Lichenoid Mucositis. J Dent Res. 2018;97:767-72.

https://doi.org/10.1177/0022034517748639

PMid:29328891 PMCid:PMC6728589

17. Kang JH, Kwon JE. Autoimmunity and epithelial dysplasia in patients with oral lichenoid diseases. Oral Dis. 2024; [Epub ahead of print].

https://doi.org/10.1111/odi.14988

PMid:38764316 

18. González-Moles MÁ, Ruiz-Ávila I, González-Ruiz L, Ayén Á, Gil-Montoya JA, Ramos-García P. Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis. Oral Oncol. 2019;96:121-30.

https://doi.org/10.1016/j.oraloncology.2019.07.012

PMid:31422203 

19. González-Moles MÁ, Ramos-García P. An Evidence-Based Update on the Potential for Malignancy of Oral Lichen Planus and Related Conditions: A Systematic Review and Meta-Analysis. Cancers (Basel). 2024;16:608.

https://doi.org/10.3390/cancers16030608

PMid:38339358 PMCid:PMC10854587

20. Fitzpatrick SG, Honda KS, Sattar A, Hirsch SA. Histologic lichenoid features in oral dysplasia and squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117:511-20.

https://doi.org/10.1016/j.oooo.2013.12.413

PMid:24560560 

21. van der Meij EH, Mast H, van der Waal I. The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year follow-up study of 192 patients. Oral Oncol. 2007;43:742-8.

https://doi.org/10.1016/j.oraloncology.2006.09.006

PMid:17112770 

22. Doust J, Vandvik PO, Qaseem A, Mustafa RA, Horvath AR, Frances A, et al. Guidance for Modifying the Definition of Diseases. JAMA Intern Med. 2017;177:1020.

https://doi.org/10.1001/jamainternmed.2017.1302

PMid:28505266 

23. McParland H, Warnakulasuriya S. Lichenoid morphology could be an early feature of oral proliferative verrucous leukoplakia. J Oral Pathol Med. 2021;50:229-35.

https://doi.org/10.1111/jop.13129

PMid:33185900 

24. Garcia-Pola MJ, Llorente-Pendás S, González-Garcia M, García-Martín JM. The development of proliferative verrucous leukoplakia in oral lichen planus. A preliminary study. Med Oral Patol Oral Cir Bucal. 2016;21:e328-34.

https://doi.org/10.4317/medoral.20832

PMid:27031060 PMCid:PMC4867206

25. Hansen LS, Olson JA, Silverman S. Proliferative verrucous leukoplakia. A long-term study of thirty patients. Oral Surg Oral Med Oral Pathol. 1985;60:285-98.

https://doi.org/10.1016/0030-4220(85)90313-5

PMid:3862042 

26. González-Moles MÁ, Ramos-García P, Warnakulasuriya S. A Scoping Review on Gaps in the Diagnostic Criteria for Proliferative Verrucous Leukoplakia: A Conceptual Proposal and Diagnostic Evidence-Based Criteria. Cancers (Basel). 2021;13:3669.

https://doi.org/10.3390/cancers13153669

PMid:34359571 PMCid:PMC8345058

27. Ramos-García P, González-Moles MÁ, Mello FW, Bagan JV, Warnakulasuriya S. Malignant transformation of oral proliferative verrucous leukoplakia: A systematic review and meta-analysis. Oral Dis. 2021;27:1896-907.

https://doi.org/10.1111/odi.13831

PMid:34009718 

28. Tabor MP, Brakenhoff RH, van Houten VM, Kummer JA, Snel MH, Snijders PJ, et al. Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications. Clin Cancer Res. 2001;7:1523-32.

PMid:35596256 PMCid:PMC9541998

29. Lodi G, Scully C, Carrozzo M, Griffiths M, Sugerman PB, Thongprasom K. Current controversies in oral lichen planus: report of an international consensus meeting. Part 2. Clinical management and malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100:164-78.

https://doi.org/10.1016/j.tripleo.2004.06.076

PMid:16037774 

30. Gonzalez-Moles MA, Gil-Montoya JA, Ruiz-Avila I, Esteban F, Bascones-Martinez A. Differences in the expression of p53 protein in oral lichen planus based on the use of monoclonal antibodies DO7 and pAb 240. Oral Oncol. 2008;44:496-503.

https://doi.org/10.1016/j.oraloncology.2007.06.013

PMid:17826304 

31. González Moles MA, Esteban F, Ruiz-Avila I, Gil Montoya JA, Brener S, Bascones-Martínez A, et al. A role for the substance P/NK-1 receptor complex in cell proliferation and apoptosis in oral lichen planus. Oral Dis. 2009;15:162-9.

https://doi.org/10.1111/j.1601-0825.2008.01504.x

PMid:19036058 

32. González-Moles MA, Bascones-Ilundain C, Gil Montoya JA, Ruiz-Avila I, Delgado-Rodríguez M, Bascones-Martínez A. Cell cycle regulating mechanisms in oral lichen planus: molecular bases in epithelium predisposed to malignant transformation. Arch Oral Biol. 2006;51:1093-103.

https://doi.org/10.1016/j.archoralbio.2006.06.007

PMid:16914114 

33. Bascones-Ilundain C, González-Moles MÁ, Campo-Trapero J, Gil-montoya JA, Esparza-Gómez GC, Cano-Sánchez J, et al. No differences in caspase-3 and Bax expression in atrophic-erosive vs. reticular oral lichen planus. J Eur Acad Dermatology Venereol. 2008;22:204-12.

https://doi.org/10.1111/j.1468-3083.2007.02387.x

PMid:18211414 

34. Keim-del Pino C, Ramos-García P, González-Moles MÁ. A Molecular Hypothesis on Malignant Transformation of Oral Lichen Planus: A Systematic Review and Meta-Analysis of Cancer Hallmarks Expression in This Oral Potentially Malignant Disorder. Cancers (Basel). 2024;16:2614.

https://doi.org/10.3390/cancers16152614

PMid:39123342 PMCid:PMC11311016

35. González-Moles MÁ, Keim-del Pino C, Ramos-García P. Hallmarks of Cancer Expression in Oral Lichen Planus: A Scoping Review of Systematic Reviews and Meta-Analyses. Int J Mol Sci. 2022;23:13099.

https://doi.org/10.3390/ijms232113099

PMid:36361889 PMCid:PMC9658487

36. Masetti R, Tiri A, Tignanelli A, Turrini E, Argentiero A, Pession A, et al. Autoimmunity and cancer. Autoimmun Rev. 2021;20:102882.

https://doi.org/10.1016/j.autrev.2021.102882

PMid:34229048 

37. Aghbari SM, Abushouk AI, Attia A, Elmaraezy A, Menshawy A, Ahmed MS, et al. Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data. Oral Oncol. 2017;68:92-102.

https://doi.org/10.1016/j.oraloncology.2017.03.012

PMid:28438300 

38. Giuliani M, Troiano G, Cordaro M, Corsalini M, Gioco G, Lo Muzio L, et al. Rate of malignant transformation of oral lichen planus: A systematic review. Oral Dis. 2018;25:693-709.

https://doi.org/10.1111/odi.12885

PMid:29738106 

39. Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, et al. Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and metaanalysis of malignant transformation rate by subtype. Head Neck. 2019;42:539-55.

https://doi.org/10.1002/hed.26006

PMid:31803979 

40. González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, González-Ruiz L, Ayén Á, Lenouvel D, et al. Clinicopathological and prognostic characteristics of oral squamous cell carcinomas arising in patients with oral lichen planus: A systematic review and a comprehensive meta-analysis. Oral Oncol. 2020;106:104688.

https://doi.org/10.1016/j.oraloncology.2020.104688

PMid:32305649