Melo A, Flores-Fraile J, Lo Giudice R, Marchetti E, Nart J, Greethurst AR, Voltas FR, Tarallo F, Galletti C. Association Between Alzheimer’s Disease and Periodontal Inflammatory Parameters: A Systematic Review. J Clin Exp Dent. 2025;17(3):e310-23.

doi:10.4317/jced.62519

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References

1. Pritchard AB, Crean S, Olsen I, Singhrao SK. Periodontitis, microbiomes and their role in Alzheimer's Disease. Front Aging Neurosci. 2017;9:336. https://doi.org/10.3389/fnagi.2017.00336 PMid:29114218 PMCid:PMC5660720

2. Li M, Donkor IK, Shao R, Hsieh S, Jiang X, Hong L, et al. Effects of Alzheimer's disease and related dementias on dental care usage and economic burden in older adults: a cross-sectional study. BMJ Open. 2023;13(6):e068944. https://doi.org/10.1136/bmjopen-2022-068944 PMid:37316312 PMCid:PMC10277067

3. Liu S, Dashper SG, Zhao R. Association Between Oral Bacteria and Alzheimer's Disease: A Systematic Review and Meta-Analysis. J Alzheimers Dis. 2023;91(1):129-150. https://doi.org/10.3233/JAD-220627 PMid:36404545

4. Carballo Á, López-Dequidt I, Custodia A, Botelho J, Aramburu-Núñez M, Machado V, et al. Association of periodontitis with cognitive decline and its progression: Contribution of blood-based biomarkers of Alzheimer's disease to this relationship. J Clin Periodontol. 2023;50(11):1444-1454. https://doi.org/10.1111/jcpe.13861 PMid:37584311

5. Wereszczyński M, Śmigiel A, Tomaszewska I, Niedźwieńska A. Investigating the relationship between periodontitis and specific memory processes in the search for cognitive markers of Alzheimer's disease risk. Sci Rep. 2023;13(1):11555. https://doi.org/10.1038/s41598-023-38674-w PMid:37464028 PMCid:PMC10353983

6. Zhao C, Kuraji R, Ye C, Gao L, Radaic A, Kamarajan P, et al. Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer's disease-like neuroinflammation triggered by periodontal disease. Journal of neuroinflammation. 2023;20(1):1-228. https://doi.org/10.1186/s12974-023-02915-6 PMid:37803465 PMCid:PMC10557354

7. Weber C, Dilthey A, Finzer P. The role of microbiome-host interactions in the development of Alzheimer's disease. Frontiers in cellular and infection microbiology. 2023;13:1151021-1151021. https://doi.org/10.3389/fcimb.2023.1151021 PMid:37333848 PMCid:PMC10272569

8. Marruganti C, Baima G, Aimetti M, Grandini S, Sanz M, Romandini M. Periodontitis and low cognitive performance: A population-based study. J Clin Periodontol. 2023;50(4):418-429. https://doi.org/10.1111/jcpe.13779 PMid:36644802

9. Mao S, Huang C, Lan H, Lau H, Chiang C, Chen Y. Association of periodontitis and oral microbiomes with Alzheimer's disease: A narrative systematic review. J Dent Sci. 2022;17(4):1762-714. https://doi.org/10.1016/j.jds.2022.07.001 PMid:36299333 PMCid:PMC9588805

10. Jungbauer G, Stähli A, Zhu X, Auber Alberi L, Sculean A, Eick S. Periodontal microorganisms and Alzheimer disease - A causative relationship? Periodontol 2000. 2022;89(1):59-82. https://doi.org/10.1111/prd.12429 PMid:35244967 PMCid:PMC9314828

11. Ma KS, Hasturk H, Carreras I, Dedeoglu A, Veeravalli JJ, Huang JY, et al. Dementia and the Risk of Periodontitis: A Population-Based Cohort Study. J Dent Res. 2022;101(3):270-277. https://doi.org/10.1177/00220345211037220 PMid:34643147 PMCid:PMC8982009

12. Li X, Kiprowska M, Kansara T, Kansara P, Li P. Neuroinflammation: A Distal Consequence of Periodontitis. J Dent Res. 2022;101(12):1441-1449. https://doi.org/10.1177/00220345221102084 PMid:35708472 PMCid:PMC9608094

13. Pazos P, Leira Y, Domínguez C, Pías-Peleteiro JM, Blanco J, Aldrey JM. Association between periodontal disease and dementia: A literature review. Neurologia (Engl Ed). 2018;33(9):602-613. https://doi.org/10.1016/j.nrl.2016.07.013 PMid:27780615

14. Syrjälä AH, Ylöstalo P, Ruoppi P, Komulainen K, Hartikainen S, Sulkava R, et al. Dementia and oral health among subjects aged 75 years or older. Gerodontology. 2012 Mar;29(1):36-42. https://doi.org/10.1111/j.1741-2358.2010.00396.x PMid:20604811

15. Aragón F, Zea-Sevilla MA, Montero J, Sancho P, Corral R, Tejedor C, et al. Oral health in Alzheimer's disease: a multicenter case-control study. Clin Oral Investig. 2018;22(9):3061-3070. https://doi.org/10.1007/s00784-018-2396-z PMid:29476334

16. Delwel S, Binnekade TT, Perez RSGM, Hertogh CMPM, Scherder EJA, Lobbezoo F. Oral hygiene and oral health in older people with dementia: a comprehensive review with focus on oral soft tissues. Clin Oral Investig. 2018;22(1):93-108. https://doi.org/10.1007/s00784-017-2264-2 PMid:29143189 PMCid:PMC5748411

17. Kaliamoorthy S, Nagarajan M, Sethuraman V, Jayavel K, Lakshmanan V, Palla S. Association of Alzheimer's disease and periodontitis - a systematic review and meta-analysis of evidence from observational studies. Med Pharm Rep. 2022;95(2):144-151. https://doi.org/10.15386/mpr-2278 PMid:35721037 PMCid:PMC9176309

18. Kikuchi T, Hayashi J, Mitani A. Next-Generation Examination, Diagnosis, and Personalized Medicine in Periodontal Disease. JPM. 2022;12(10):1743. https://doi.org/10.3390/jpm12101743 PMid:36294882 PMCid:PMC9605396

19. Ryder MI, Xenoudi P. Alzheimer disease and the periodontal patient: New insights, connections, and therapies. Periodontol 2000. 2021;87(1):32-42. https://doi.org/10.1111/prd.12389 PMid:34463981

20. Borsa L, Dubois M, Sacco G, Lupi L. Analysis the Link between Periodontal Diseases and Alzheimer's Disease: A Systematic Review. Int J Environ Res Public Health. 2021;18(17):9312. https://doi.org/10.3390/ijerph18179312 PMid:34501899 PMCid:PMC8430572

21. Hu X, Zhang J, Qiu Y, Liu Z. Periodontal disease and the risk of Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis. Psychogeriatrics. 2021;21(5):813-825. https://doi.org/10.1111/psyg.12743 PMid:34247432

22. Sun Y, Richmond RC, Chen Y, Mai X. Relationship between periodontitis and Alzheimer's disease: a bidirectional Mendelian randomization study. Norsk epidemiologi. 2019;28:81.

23. Holmer J, Eriksdotter M, Schultzberg M, Pussinen PJ, Buhlin K. Association between periodontitis and risk of Alzheimer′s disease, mild cognitive impairment and subjective cognitive decline: A case-control study. J Clin Periodontol. 2018;45(11):1287-1298. https://doi.org/10.1111/jcpe.13016 PMid:30289998

24. Leira Y, Domínguez C, Seoane J, Seoane-Romero J, Pías-Peleteiro JM, Takkouche B, et al. Is Periodontal Disease Associated with Alzheimer's Disease? A Systematic Review with Meta-Analysis. Neuroepidemiology. 2017;48(1-2):21-31. https://doi.org/10.1159/000458411 PMid:28219071

25. Ide M, Harris M, Stevens A, Sussams R, Hopkins V, Culliford D, et al. Periodontitis and Cognitive Decline in Alzheimer's Disease. PLoS One. 2016;11(3):e0151081. https://doi.org/10.1371/journal.pone.0151081 PMid:26963387 PMCid:PMC4786266

26. Guo H, Chang S, Pi X, Hua F, Jiang H, Liu C, et al. The Effect of Periodontitis on Dementia and Cognitive Impairment: A Meta-Analysis. International journal of environmental research and public health. 2021;18(13):6823. https://doi.org/10.3390/ijerph18136823 PMid:34202071 PMCid:PMC8297088

27. Bui FQ, Almeida-da-Silva C, Coutinho L, Huynh B, Trinh A, Liu J, Woodward J, et al. Association between periodontal pathogens and systemic disease. Biomedical journal; Biomed J. 2019;42(1):27-35. https://doi.org/10.1016/j.bj.2018.12.001 PMid:30987702 PMCid:PMC6468093

28. Maldonado A, Laugisch O, Bürgin W, Sculean A, Eick S. Clinical periodontal variables in patients with and without dementia-a systematic review and meta-analysis. Clin Oral Investig. 2018;22(7):2463-2474. https://doi.org/10.1007/s00784-018-2523-x PMid:29934798

29. Hasturk H, Schulte F, Martins M, Sherzai H, Floros C, Cugini M, et al. Safety and Preliminary Efficacy of a Novel Host-Modulatory Therapy for Reducing Gingival Inflammation. Front Immunol. 2021;12:704163. https://doi.org/10.3389/fimmu.2021.704163 PMid:34589083 PMCid:PMC8475270

30. Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A, et al. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019;5(1):eaau3333. https://doi.org/10.1126/sciadv.aau3333 PMid:30746447 PMCid:PMC6357742

31. Teixeira FB, Saito MT, Matheus FC, Prediger RD, Yamada ES, Maia CSF, et al. Periodontitis and alzheimer's disease: A possible comorbidity between oral chronic inflammatory condition and neuroinflammation. Frontiers in Aging Neuroscience; Front Aging Neurosci. 2017;9:327. https://doi.org/10.3389/fnagi.2017.00327 PMid:29085294 PMCid:PMC5649154

32. Dioguardi M, Crincoli V, Laino L, Alovisi M, Sovereto D, Mastrangelo F, et al. The Role of Periodontitis and Periodontal Bacteria in the Onset and Progression of Alzheimer's Disease: A Systematic Review. J Clin Med. 2020;9(2):495. https://doi.org/10.3390/jcm9020495 PMid:32054121 PMCid:PMC7074205

33. Harding A, Singhrao SK. Periodontitis and Dementia: A Bidirectional Relationship? Journal of dental research. 2022;101(3):245-246. https://doi.org/10.1177/00220345211043461 PMid:34657515 PMCid:PMC8864330

34. Nadim R, Tang J, Dilmohamed A, Yuan S, Wu C, Bakre AT, et al. Influence of periodontal disease on risk of dementia: a systematic literature review and a meta-analysis. European journal of epidemiology. 2020;35(9):821-833. https://doi.org/10.1007/s10654-020-00648-x PMid:32533373

35. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1-1. https://doi.org/10.1186/2046-4053-4-1 PMid:25554246 PMCid:PMC4320440

36. Schardt C, Adams MB, Owens T, Keitz S, Fontelo P. Utilization of the PICO framework to improve searching PubMed for clinical questions. BMC Med Inform Decis Mak. 2007;7:16-16. https://doi.org/10.1186/1472-6947-7-16 PMid:17573961 PMCid:PMC1904193

37. Martande SS, Pradeep AR, Sonender PS, Kumari M, Deepak KS, Raju AP, et al. Periodontal Health Condition in Patients with Alzheimer's Disease. Am J Alzheimers Dis Other Demen. 2014;29(6):498-502. https://doi.org/10.1177/1533317514549650 PMid:25214647 PMCid:PMC10852660

38. Dominy D, Lynch L, Ermini F, Benedyk B, Marczyk M, Konradi K, et al. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019;5(1):eaau3333. https://doi.org/10.1126/sciadv.aau3333 PMid:30746447 PMCid:PMC6357742